TIAM2

TIAM Rac1 associated GEF 2

Summary

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Known Variants127 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs13201764	6:155,332,118	T/C	intron variant	—
rs574552866	6:155,443,636	G/T	—	—
rs114808212	6:155,450,378	G/C	—	likely benign
rs2533669701	6:155,450,383	C/T	—	uncertain significance
rs562009542	6:155,450,394	T/C	—	uncertain significance
rs201514936	6:155,450,454	C/T	—	uncertain significance
rs371544718	6:155,450,570	C/G	—	uncertain significance
rs748553008	6:155,450,698	A/G	—	uncertain significance
rs141676445	6:155,450,719	A/C	—	uncertain significance
rs1004265027	6:155,450,772	A/G	—	uncertain significance
rs148543891	6:155,450,779	A/G	missense variant	—
rs773676319	6:155,450,824	G/T	—	uncertain significance
rs145714158	6:155,450,976	G/C	—	uncertain significance
rs1038452917	6:155,450,989	T/C	—	uncertain significance
rs202198389	6:155,451,015	G/A	—	uncertain significance
rs369321093	6:155,451,042	T/A	—	uncertain significance
rs758068877	6:155,451,049	C/T	—	uncertain significance
rs756796322	6:155,451,058	G/A	—	uncertain significance
rs754457084	6:155,451,109	A/G	—	uncertain significance
rs1338925570	6:155,451,150	G/C	—	uncertain significance
rs1380799287	6:155,451,151	G/A	—	uncertain significance
rs199946763	6:155,451,168	G/A	—	likely benign
rs2533672036	6:155,451,207	G/A	—	uncertain significance
rs771110749	6:155,451,250	C/T	—	uncertain significance
rs2533672191	6:155,451,285	A/C	—	uncertain significance
rs2533672283	6:155,451,316	A/C	—	uncertain significance
rs903162305	6:155,451,349	A/G	—	uncertain significance
rs1779415271	6:155,451,362	T/G	—	uncertain significance
rs147918987	6:155,451,372	A/G	—	likely benign
rs764768297	6:155,451,438	C/T	—	uncertain significance
rs1463581837	6:155,451,439	G/A	—	uncertain significance
rs1186119799	6:155,451,443	G/T	—	uncertain significance
rs763757459	6:155,451,453	T/C	—	likely benign
rs79755976	6:155,451,464	T/C	—	benign
rs757500376	6:155,451,469	C/T	—	uncertain significance
rs114815467	6:155,451,476	G/T	—	benign
rs772490486	6:155,451,501	C/T	—	uncertain significance
rs775097601	6:155,451,506	C/G	—	uncertain significance
rs754644828	6:155,451,522	A/C	—	uncertain significance
rs1188347188	6:155,451,523	G/A	—	uncertain significance
rs544766632	6:155,451,643	G/A	—	—
rs768120057	6:155,458,315	C/T	—	uncertain significance
rs147313642	6:155,458,459	C/T	—	uncertain significance
rs766127122	6:155,458,470	G/T	—	uncertain significance
rs2533686480	6:155,458,541	C/A	—	uncertain significance
rs754587537	6:155,458,543	T/C	—	uncertain significance
rs764401822	6:155,458,563	G/A	—	uncertain significance
rs144697464	6:155,458,565	C/T	—	benign
rs767851710	6:155,458,634	G/A	—	likely benign
rs532975268	6:155,458,665	C/T	—	uncertain significance
rs138845881	6:155,464,545	C/G	—	—
rs759334588	6:155,469,321	T/G	—	uncertain significance
rs200977411	6:155,469,335	C/T	—	uncertain significance
rs138017039	6:155,469,341	G/A	—	uncertain significance
rs770582570	6:155,469,391	A/T	—	uncertain significance
rs202138720	6:155,469,436	G/T	—	uncertain significance
rs377169813	6:155,485,666	G/A	—	likely benign
rs77863116	6:155,486,392	A/C	—	benign
rs550597056	6:155,486,424	C/T	—	uncertain significance
rs117029710	6:155,486,450	G/A	—	likely benign
rs773737287	6:155,486,452	G/A	—	uncertain significance
rs751384917	6:155,486,482	C/T	—	uncertain significance
rs62621836	6:155,486,535	A/G	—	benign
rs146936788	6:155,497,953	G/C	—	uncertain significance
rs137976809	6:155,497,995	C/A	—	uncertain significance
rs756261390	6:155,500,523	A/C	—	uncertain significance
rs138915668	6:155,500,544	T/C	—	likely benign
rs779254117	6:155,500,551	G/C	—	uncertain significance
rs2533792391	6:155,500,569	A/G	—	uncertain significance
rs768733622	6:155,503,375	C/T	—	uncertain significance
rs7770537	6:155,503,390	G/A	—	benign
rs1343541022	6:155,503,393	A/G	—	uncertain significance
rs1454875501	6:155,503,406	G/A	—	likely benign
rs765700396	6:155,503,422	G/A	—	uncertain significance
rs59134422	6:155,503,430	C/T	—	benign
rs190556371	6:155,504,430	C/T	—	uncertain significance
rs201772716	6:155,504,446	C/T	—	uncertain significance
rs150560357	6:155,504,469	G/A	—	likely benign
rs955780322	6:155,504,494	C/T	—	likely benign
rs145603552	6:155,504,495	G/C	—	likely benign
rs2533802054	6:155,504,498	C/A	—	uncertain significance
rs73577403	6:155,504,505	G/A	—	benign
rs1025566964	6:155,532,434	C/T	—	uncertain significance
rs745535	6:155,540,763	A/T	—	—
rs6908258	6:155,551,005	C/G	—	—
rs868236717	6:155,561,718	G/A	—	likely benign
rs768725095	6:155,561,748	C/T	—	uncertain significance
rs201303380	6:155,561,752	C/T	—	uncertain significance
rs2533951382	6:155,561,759	G/T	—	uncertain significance
rs755437912	6:155,561,769	C/T	—	uncertain significance
rs201811882	6:155,561,791	G/A	—	uncertain significance
rs780507785	6:155,561,803	T/G	—	uncertain significance
rs149353490	6:155,561,838	G/C	—	uncertain significance
rs2533966346	6:155,565,146	A/C	—	uncertain significance
rs1264152299	6:155,565,194	C/T	—	uncertain significance
rs199687688	6:155,565,795	G/C	—	uncertain significance
rs1376259588	6:155,565,824	G/A	—	uncertain significance
rs2533969670	6:155,565,855	C/G	—	uncertain significance
rs779632228	6:155,566,863	G/A	—	uncertain significance
rs11756255	6:155,567,883	A/C	—	—

Showing 100 of 127 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.