TIMELESS

timeless circadian regulator

Summary

The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]

Known Variants105 total

rsidPosition (GRCh37)AllelesClassClinVar
rs15114697412:56,811,549C/T—likely benign
rs77437146512:56,811,562A/C—uncertain significance
rs254729291312:56,811,747T/G—uncertain significance
rs77113366912:56,811,768G/A—uncertain significance
rs117195696412:56,811,772C/G—uncertain significance
rs77568219512:56,811,783G/T—uncertain significance
rs15005593812:56,811,784C/T—likely benign
rs75324642712:56,811,922T/C—likely benign
rs86808117112:56,811,930C/T—uncertain significance
rs6193771612:56,811,937C/T—likely benign
rs14889750312:56,811,975C/G—uncertain significance
rs37079748412:56,811,979T/C—likely benign
rs14558528012:56,811,983C/T—uncertain significance
rs254729309912:56,811,993T/C—uncertain significance
rs139745646212:56,812,048C/G—uncertain significance
rs26760358212:56,812,110G/A—uncertain significance
rs146509239112:56,812,131G/A—pathogenic
rs6174869412:56,814,403A/G—benign
rs14149064812:56,814,409C/T—uncertain significance
rs14963109512:56,814,430T/C—uncertain significance
rs254729456712:56,814,454G/C—uncertain significance
rs90021739912:56,814,459G/C—uncertain significance
rs13915592212:56,814,780T/C—uncertain significance
rs134114600812:56,814,824C/G—uncertain significance
rs14412864112:56,815,163C/T—uncertain significance
rs78105028712:56,815,164G/A—uncertain significance
rs14651843212:56,815,184C/T—uncertain significance
rs14116543912:56,815,185G/A—uncertain significance
rs76842522412:56,815,232C/T—uncertain significance
rs7247899912:56,815,238C/T—uncertain significance
rs20153700012:56,815,275C/T—benign
rs229173812:56,815,281T/Csplice region variant—
rs6175365312:56,815,523G/A—likely benign
rs11291808912:56,815,588C/T—uncertain significance
rs75256724812:56,815,685T/C—likely benign
rs77114449412:56,815,758A/C—uncertain significance
rs76599597912:56,815,899C/T—conflicting classifications of pathogenicity
rs75450348212:56,815,908C/T—uncertain significance
rs76464606512:56,815,909G/A—likely benign
rs14713416912:56,815,964C/T—uncertain significance
rs76808181212:56,816,649T/C—uncertain significance
rs254729628412:56,816,660C/A—uncertain significance
rs76944521912:56,816,762A/T—uncertain significance
rs18948437312:56,817,092C/T—uncertain significance
rs76667700812:56,817,093G/A—uncertain significance
rs75465997512:56,817,146T/C—uncertain significance
rs53471245712:56,817,149T/C—uncertain significance
rs127119270812:56,817,220T/A—likely benign
rs77867610512:56,817,221A/G—uncertain significance
rs75803113112:56,817,236C/T—uncertain significance
rs11144585612:56,817,259G/A—likely benign
rs76390068112:56,817,404G/A—uncertain significance
rs188157959612:56,817,467C/T—uncertain significance
rs11237625912:56,817,500A/G—benign
rs254729730512:56,817,652A/G—uncertain significance
rs76785819112:56,818,609C/T—uncertain significance
rs14045005012:56,818,634C/T—uncertain significance
rs254729787812:56,818,640C/T—uncertain significance
rs125821759712:56,818,681A/G—uncertain significance
rs11232759612:56,818,682T/C—benign
rs254729791512:56,818,693G/A—uncertain significance
rs37676800612:56,818,860C/T—uncertain significance
rs14524473512:56,818,863G/A—uncertain significance
rs14182794412:56,822,048C/T—likely benign
rs6175246012:56,822,071G/A—benign
rs138592062912:56,822,076G/C—uncertain significance
rs37098035812:56,822,082T/C—uncertain significance
rs135103748212:56,822,104G/C—uncertain significance
rs76684818512:56,822,111C/T—uncertain significance
rs55004832812:56,822,112G/A—uncertain significance
rs103223634612:56,822,117T/G—uncertain significance
rs254729932412:56,822,142A/G—uncertain significance
rs77267747112:56,822,145G/A—uncertain significance
rs254729937612:56,822,185A/C—uncertain significance
rs145102881312:56,822,339T/A—uncertain significance
rs14343749012:56,822,345G/C—uncertain significance
rs20095708112:56,822,668G/A—uncertain significance
rs15104536312:56,822,694C/T—uncertain significance
rs254729977512:56,822,715T/C—uncertain significance
rs53265259712:56,822,776C/T—uncertain significance
rs76400568312:56,822,787C/T—likely benign
rs74941782112:56,823,903T/C—uncertain significance
rs14792119612:56,823,908C/T—uncertain significance
rs54507377712:56,823,965T/A—uncertain significance
rs74954043712:56,823,971G/T—uncertain significance
rs74696589312:56,823,978G/A—uncertain significance
rs75653557812:56,824,011G/A—uncertain significance
rs254730108112:56,824,660C/T—uncertain significance
rs20092020312:56,824,703C/T—uncertain significance
rs14242979312:56,824,741A/G—uncertain significance
rs20197468912:56,825,276C/T—uncertain significance
rs19980998812:56,825,355G/A—uncertain significance
rs37402967912:56,826,160C/T—uncertain significance
rs37295668512:56,826,216C/T—likely benign
rs77688992212:56,826,220C/G—uncertain significance
rs78137228312:56,826,293C/A—uncertain significance
rs125152447312:56,826,824G/A—likely benign
rs145438436812:56,826,910C/T—uncertain significance
rs7247898612:56,827,209C/A—likely benign
rs36916279912:56,827,619G/A—likely benign

Showing 100 of 105 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.