TINAG

tubulointerstitial nephritis antigen

Summary

This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011]

Known Variants40 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1440647426:54,173,381T/Gbenign
rs1478980996:54,173,485G/Cuncertain significance
rs7564908016:54,173,496G/Cuncertain significance
rs1415948316:54,173,631T/Cuncertain significance
rs5612964376:54,173,673C/Guncertain significance
rs5300835256:54,173,674C/Tuncertain significance
rs1876907476:54,185,934C/Tintron variant
rs3680917356:54,186,102T/Auncertain significance
rs10587686:54,186,147T/Gmissense variant
rs12020819056:54,186,156A/Guncertain significance
rs7562479346:54,186,174G/Auncertain significance
rs17846163566:54,191,712A/Tuncertain significance
rs2006996636:54,208,024G/Auncertain significance
rs3695235746:54,208,063G/Alikely benign
rs24813529156:54,208,081C/Tuncertain significance
rs3737054656:54,208,111A/Guncertain significance
rs17850446906:54,208,114A/Cuncertain significance
rs24813533366:54,208,117T/Cuncertain significance
rs7730734326:54,212,284G/Auncertain significance
rs1997414296:54,212,287A/Guncertain significance
rs7810495666:54,214,527G/Auncertain significance
rs15827294656:54,214,567A/Glikely benign
rs1444082096:54,214,579T/Cuncertain significance
rs7686369886:54,214,589G/Tuncertain significance
rs17852185446:54,214,602G/Auncertain significance
rs7718989416:54,214,626T/Cuncertain significance
rs1452028276:54,214,638G/Alikely benign
rs9207672706:54,214,677T/Cuncertain significance
rs7749932126:54,216,151A/Tuncertain significance
rs9784050836:54,216,186C/Tuncertain significance
rs24813948526:54,219,329A/Guncertain significance
rs17853459246:54,219,349A/Tuncertain significance
rs7553509606:54,219,406C/Tuncertain significance
rs1432110696:54,219,410A/Glikely benign
rs1396353856:54,245,367T/Guncertain significance
rs7711099256:54,254,646C/Tuncertain significance
rs2017839606:54,254,647G/Auncertain significance
rs3716967776:54,254,652G/Auncertain significance
rs7623375026:54,254,664G/Auncertain significance
rs7790471056:54,254,704C/Tuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.