TLE3
TLE family member 3, transcriptional corepressor
Summary
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Known Variants41 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs780171986 | 15:70,342,503 | G/A | — | uncertain significance |
| rs35256928 | 15:70,342,529 | C/T | — | benign |
| rs752738182 | 15:70,343,795 | C/T | — | uncertain significance |
| rs151239650 | 15:70,345,692 | A/G | — | benign |
| rs115450913 | 15:70,345,695 | T/C | — | benign |
| rs758966993 | 15:70,346,814 | T/C | — | uncertain significance |
| rs114111473 | 15:70,346,851 | G/A | — | benign |
| rs373800721 | 15:70,346,942 | G/C | — | uncertain significance |
| rs2542812727 | 15:70,347,005 | C/T | — | uncertain significance |
| rs2542812829 | 15:70,347,006 | G/T | — | uncertain significance |
| rs764899809 | 15:70,348,659 | C/T | — | uncertain significance |
| rs2542607151 | 15:70,349,979 | G/A | — | uncertain significance |
| rs759781735 | 15:70,349,994 | G/A | — | uncertain significance |
| rs2291982 | 15:70,350,457 | C/A | intron variant | — |
| rs746708122 | 15:70,350,495 | T/C | — | uncertain significance |
| rs368541478 | 15:70,350,533 | G/A | — | uncertain significance |
| rs777121473 | 15:70,350,576 | C/T | — | uncertain significance |
| rs200743621 | 15:70,350,628 | G/A | — | likely benign |
| rs1392928123 | 15:70,351,010 | G/A | — | uncertain significance |
| rs1403740075 | 15:70,351,013 | C/G | — | uncertain significance |
| rs2141504799 | 15:70,351,045 | G/C | — | uncertain significance |
| rs2542708723 | 15:70,351,753 | T/G | — | uncertain significance |
| rs2542709080 | 15:70,351,760 | C/T | — | uncertain significance |
| rs2133977 | 15:70,351,788 | T/C | — | benign |
| rs1168306984 | 15:70,352,937 | C/T | — | uncertain significance |
| rs2228176 | 15:70,352,968 | C/A | — | likely benign |
| rs2056409271 | 15:70,352,987 | T/C | — | uncertain significance |
| rs201235666 | 15:70,358,365 | G/A | — | uncertain significance |
| rs199583327 | 15:70,358,394 | G/A | — | uncertain significance |
| rs763567018 | 15:70,358,487 | G/A | — | uncertain significance |
| rs750981911 | 15:70,358,488 | G/A | — | uncertain significance |
| rs749339059 | 15:70,358,541 | G/A | — | uncertain significance |
| rs776335125 | 15:70,366,930 | G/A | — | uncertain significance |
| rs2543192508 | 15:70,368,454 | A/G | — | uncertain significance |
| rs766416911 | 15:70,368,487 | G/A | — | uncertain significance |
| rs11630316 | 15:70,369,378 | T/C | downstream gene variant | — |
| rs36085856 | 15:70,379,236 | G/C | regulatory region variant | — |
| rs35485240 | 15:70,379,533 | A/C | intron variant | — |
| rs547396438 | 15:70,386,922 | G/A | — | likely benign |
| rs1052664727 | 15:70,387,945 | T/C | — | uncertain significance |
| rs2058517340 | 15:70,387,955 | C/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.