TLE4
TLE family member 4, transcriptional corepressor
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of DNA-templated transcription. Located in nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs750655876 | 9:82,188,615 | G/T | — | uncertain significance |
| rs184488658 | 9:82,213,942 | C/T | — | — |
| rs145598309 | 9:82,219,465 | A/G | intron variant | — |
| rs118119317 | 9:82,226,685 | G/A | intron variant | — |
| rs191751273 | 9:82,237,781 | T/G | — | — |
| rs2541277269 | 9:82,267,644 | T/A | — | uncertain significance |
| rs11138325 | 9:82,294,364 | C/T | intron variant | — |
| rs10867411 | 9:82,297,990 | A/C | — | — |
| rs914715 | 9:82,310,898 | T/A | regulatory region variant | — |
| rs771858534 | 9:82,320,846 | G/A | — | uncertain significance |
| rs771413858 | 9:82,321,678 | G/A | — | uncertain significance |
| rs776714530 | 9:82,321,725 | C/T | — | uncertain significance |
| rs2072213703 | 9:82,323,082 | G/A | — | uncertain significance |
| rs181919110 | 9:82,323,122 | A/T | — | benign |
| rs2490408762 | 9:82,323,133 | T/C | — | uncertain significance |
| rs746082419 | 9:82,323,528 | A/G | — | uncertain significance |
| rs777753084 | 9:82,323,543 | C/G | — | uncertain significance |
| rs2072387113 | 9:82,323,612 | G/A | — | uncertain significance |
| rs577923277 | 9:82,323,651 | G/A | — | uncertain significance |
| rs201703349 | 9:82,324,592 | A/G | — | uncertain significance |
| rs367570785 | 9:82,333,694 | C/G | — | benign |
| rs1429243068 | 9:82,333,726 | A/G | — | uncertain significance |
| rs61742686 | 9:82,333,754 | C/T | — | benign |
| rs754065954 | 9:82,335,063 | C/T | — | uncertain significance |
| rs61112339 | 9:82,335,161 | C/T | — | benign |
| rs753167270 | 9:82,335,174 | G/A | — | uncertain significance |
| rs34566811 | 9:82,337,407 | A/C | — | benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.