TLN2

talin 2

Summary

This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008]

Known Variants209 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs2456930	15:62,687,339	C/T	intron variant	—
rs4775500	15:62,721,768	C/T	intron variant	—
rs142163046	15:62,735,249	T/A	intron variant	—
rs34444272	15:62,756,908	G/A	regulatory region variant	—
rs780142	15:62,797,964	T/A	—	—
rs7167031	15:62,825,327	C/T	intron variant	—
rs59191668	15:62,852,953	A/G	upstream gene variant	—
rs2119696	15:62,854,085	G/T	—	—
rs12913538	15:62,899,160	G/C	—	—
rs771261514	15:62,939,540	C/T	—	uncertain significance
rs1262140430	15:62,939,568	A/G	—	uncertain significance
rs764974667	15:62,939,603	C/G	—	uncertain significance
rs147199264	15:62,944,246	C/T	—	uncertain significance
rs576244868	15:62,945,364	T/C	—	uncertain significance
rs2548732874	15:62,945,416	A/C	—	uncertain significance
rs2053171426	15:62,948,245	A/T	—	uncertain significance
rs140451649	15:62,949,962	T/C	—	benign
rs779513729	15:62,966,076	A/G	—	uncertain significance
rs200982885	15:62,967,428	T/C	—	uncertain significance
rs781350490	15:62,967,467	G/A	—	uncertain significance
rs748308139	15:62,967,473	C/T	—	uncertain significance
rs199806066	15:62,967,475	C/T	—	likely benign
rs1596718206	15:62,978,866	G/C	—	likely benign
rs1260597665	15:62,978,870	C/T	—	uncertain significance
rs1406192384	15:62,978,964	G/T	—	uncertain significance
rs201885811	15:62,985,047	G/A	—	likely benign
rs1444575407	15:62,985,077	A/C	—	uncertain significance
rs2548838392	15:62,985,079	C/G	—	uncertain significance
rs773219965	15:62,985,129	A/G	—	uncertain significance
rs370693887	15:62,986,549	A/G	—	uncertain significance
rs146852692	15:62,986,576	C/G	—	uncertain significance
rs757965110	15:62,986,578	G/A	—	uncertain significance
rs764361637	15:62,989,887	G/C	—	uncertain significance
rs779511723	15:62,989,916	G/A	—	uncertain significance
rs147182716	15:62,989,968	G/A	—	likely benign
rs537587203	15:62,990,041	A/T	—	uncertain significance
rs1176920138	15:62,990,056	A/G	—	uncertain significance
rs756395223	15:62,990,062	C/T	—	uncertain significance
rs1242743838	15:62,990,955	C/T	—	likely benign
rs539690024	15:62,991,001	G/A	—	uncertain significance
rs576320794	15:62,991,041	C/T	—	uncertain significance
rs141677455	15:62,993,355	C/T	—	benign
rs763327730	15:62,993,366	T/C	—	uncertain significance
rs771752304	15:62,994,206	C/T	—	uncertain significance
rs2058747754	15:62,994,217	G/C	—	uncertain significance
rs776572724	15:62,994,257	C/A	—	uncertain significance
rs146832843	15:62,994,307	G/T	—	uncertain significance
rs148980230	15:62,994,314	G/A	—	uncertain significance
rs768470206	15:62,994,340	A/G	—	uncertain significance
rs574816226	15:62,994,365	A/C	—	uncertain significance
rs751288960	15:62,994,366	C/A	—	uncertain significance
rs765519659	15:62,994,977	G/A	—	uncertain significance
rs763427386	15:62,994,983	A/G	—	uncertain significance
rs144036109	15:62,995,056	G/C	—	uncertain significance
rs147061927	15:62,999,447	G/A	—	uncertain significance
rs138242185	15:63,000,716	A/G	—	uncertain significance
rs201247821	15:63,000,747	T/C	—	uncertain significance
rs781399224	15:63,000,764	G/A	—	uncertain significance
rs749584051	15:63,000,774	C/T	—	uncertain significance
rs144563213	15:63,000,783	A/G	—	uncertain significance
rs142680037	15:63,000,792	G/A	—	uncertain significance
rs779029456	15:63,000,837	T/G	—	uncertain significance
rs775345180	15:63,000,840	G/A	—	uncertain significance
rs150742531	15:63,000,842	G/A	—	uncertain significance
rs139110889	15:63,000,854	G/A	—	uncertain significance
rs375692009	15:63,000,893	C/T	—	uncertain significance
rs764624691	15:63,000,927	G/A	—	uncertain significance
rs757307260	15:63,000,932	G/A	—	uncertain significance
rs754795772	15:63,000,965	G/A	—	uncertain significance
rs116474698	15:63,004,129	G/A	—	benign
rs2548876282	15:63,004,163	A/G	—	uncertain significance
rs758032889	15:63,004,188	C/T	—	uncertain significance
rs147975596	15:63,004,200	T/C	—	uncertain significance
rs759685818	15:63,004,213	G/T	—	uncertain significance
rs772095104	15:63,004,238	T/G	—	uncertain significance
rs2548885019	15:63,008,545	C/T	—	uncertain significance
rs530601554	15:63,008,559	C/A	—	uncertain significance
rs1250248785	15:63,008,564	A/G	—	uncertain significance
rs2059777424	15:63,008,642	T/C	—	uncertain significance
rs767091695	15:63,008,648	A/G	—	uncertain significance
rs141002416	15:63,009,823	T/A	—	uncertain significance
rs2548887056	15:63,009,824	C/G	—	uncertain significance
rs192124826	15:63,009,832	G/A	—	uncertain significance
rs749533144	15:63,009,876	C/T	—	likely benign
rs142617029	15:63,012,025	T/C	—	likely benign
rs113672570	15:63,014,585	G/A	—	uncertain significance
rs141513413	15:63,014,597	G/A	—	uncertain significance
rs148420994	15:63,014,680	G/A	—	likely benign
rs780406121	15:63,017,179	A/G	—	uncertain significance
rs150656070	15:63,017,220	A/G	—	uncertain significance
rs747216816	15:63,017,259	A/G	—	uncertain significance
rs2548901101	15:63,017,272	A/C	—	uncertain significance
rs1181717235	15:63,017,302	C/T	—	uncertain significance
rs370120612	15:63,019,303	G/A	—	likely benign
rs2548904497	15:63,019,305	A/G	—	uncertain significance
rs1652236914	15:63,019,374	A/G	—	uncertain significance
rs78723378	15:63,019,375	C/T	—	benign
rs200129296	15:63,019,376	G/A	—	uncertain significance
rs190706301	15:63,028,860	G/T	intron variant	—
rs1567492321	15:63,029,082	G/A	—	uncertain significance

Showing 100 of 209 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.