TMC4

transmembrane channel like 4

Summary

Enables voltage-gated chloride channel activity. Predicted to be involved in sensory perception of salty taste. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants42 total

rsidPosition (GRCh37)AllelesClassClinVar
rs37345120219:54,664,052C/Tlikely benign
rs251474526019:54,664,253G/Auncertain significance
rs78031341519:54,664,646C/Tlikely benign
rs89697461119:54,664,649G/Cuncertain significance
rs77171526519:54,664,942G/Alikely benign
rs37072413019:54,665,992A/Guncertain significance
rs37359120119:54,666,011C/Tuncertain significance
rs11312475419:54,666,387C/Gregulatory region variant
rs76000803619:54,666,481T/Auncertain significance
rs11609232219:54,666,821C/Tuncertain significance
rs251480129919:54,667,557G/Alikely benign
rs14911235619:54,667,583G/Tuncertain significance
rs78111594319:54,668,202A/Tuncertain significance
rs56004365919:54,668,230C/Tuncertain significance
rs20165887219:54,668,275C/Tuncertain significance
rs76221149019:54,668,313A/Guncertain significance
rs77377680919:54,669,170T/Cuncertain significance
rs76150862319:54,669,187C/Tuncertain significance
rs77025387919:54,669,260C/Tuncertain significance
rs207568367719:54,669,298G/Auncertain significance
rs104654325919:54,671,921A/Guncertain significance
rs14724184519:54,671,966C/Tlikely benign
rs74658122419:54,671,972C/Auncertain significance
rs75677781219:54,672,230G/Aconflicting classifications of pathogenicity
rs13830311819:54,672,284G/Cuncertain significance
rs14964695419:54,672,316A/Glikely benign
rs77205218719:54,672,344C/Tuncertain significance
rs20054475019:54,672,351A/Glikely benign
rs56302885219:54,672,549T/C
rs7509764419:54,673,187C/Gdownstream gene variant
rs76902883419:54,673,306G/Cuncertain significance
rs99314970719:54,673,383G/Cuncertain significance
rs7306268419:54,674,349G/Adownstream gene variant
rs7306268619:54,674,478G/Adownstream gene variant
rs76067910819:54,675,648C/Guncertain significance
rs15056813719:54,675,649G/Auncertain significance
rs36825296619:54,675,661T/Cuncertain significance
rs11449585719:54,675,729T/Clikely benign
rs77638799719:54,675,760C/Tuncertain significance
rs251494402419:54,675,858G/Clikely benign
rs257645219:54,676,433C/Tregulatory region variant
rs14108473019:54,676,799G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.