TMC4
transmembrane channel like 4
Summary
Enables voltage-gated chloride channel activity. Predicted to be involved in sensory perception of salty taste. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants42 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs373451202 | 19:54,664,052 | C/T | — | likely benign |
| rs2514745260 | 19:54,664,253 | G/A | — | uncertain significance |
| rs780313415 | 19:54,664,646 | C/T | — | likely benign |
| rs896974611 | 19:54,664,649 | G/C | — | uncertain significance |
| rs771715265 | 19:54,664,942 | G/A | — | likely benign |
| rs370724130 | 19:54,665,992 | A/G | — | uncertain significance |
| rs373591201 | 19:54,666,011 | C/T | — | uncertain significance |
| rs113124754 | 19:54,666,387 | C/G | regulatory region variant | — |
| rs760008036 | 19:54,666,481 | T/A | — | uncertain significance |
| rs116092322 | 19:54,666,821 | C/T | — | uncertain significance |
| rs2514801299 | 19:54,667,557 | G/A | — | likely benign |
| rs149112356 | 19:54,667,583 | G/T | — | uncertain significance |
| rs781115943 | 19:54,668,202 | A/T | — | uncertain significance |
| rs560043659 | 19:54,668,230 | C/T | — | uncertain significance |
| rs201658872 | 19:54,668,275 | C/T | — | uncertain significance |
| rs762211490 | 19:54,668,313 | A/G | — | uncertain significance |
| rs773776809 | 19:54,669,170 | T/C | — | uncertain significance |
| rs761508623 | 19:54,669,187 | C/T | — | uncertain significance |
| rs770253879 | 19:54,669,260 | C/T | — | uncertain significance |
| rs2075683677 | 19:54,669,298 | G/A | — | uncertain significance |
| rs1046543259 | 19:54,671,921 | A/G | — | uncertain significance |
| rs147241845 | 19:54,671,966 | C/T | — | likely benign |
| rs746581224 | 19:54,671,972 | C/A | — | uncertain significance |
| rs756777812 | 19:54,672,230 | G/A | — | conflicting classifications of pathogenicity |
| rs138303118 | 19:54,672,284 | G/C | — | uncertain significance |
| rs149646954 | 19:54,672,316 | A/G | — | likely benign |
| rs772052187 | 19:54,672,344 | C/T | — | uncertain significance |
| rs200544750 | 19:54,672,351 | A/G | — | likely benign |
| rs563028852 | 19:54,672,549 | T/C | — | — |
| rs75097644 | 19:54,673,187 | C/G | downstream gene variant | — |
| rs769028834 | 19:54,673,306 | G/C | — | uncertain significance |
| rs993149707 | 19:54,673,383 | G/C | — | uncertain significance |
| rs73062684 | 19:54,674,349 | G/A | downstream gene variant | — |
| rs73062686 | 19:54,674,478 | G/A | downstream gene variant | — |
| rs760679108 | 19:54,675,648 | C/G | — | uncertain significance |
| rs150568137 | 19:54,675,649 | G/A | — | uncertain significance |
| rs368252966 | 19:54,675,661 | T/C | — | uncertain significance |
| rs114495857 | 19:54,675,729 | T/C | — | likely benign |
| rs776387997 | 19:54,675,760 | C/T | — | uncertain significance |
| rs2514944024 | 19:54,675,858 | G/C | — | likely benign |
| rs2576452 | 19:54,676,433 | C/T | regulatory region variant | — |
| rs141084730 | 19:54,676,799 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.