TMEM259
transmembrane protein 259
Summary
Predicted to be involved in positive regulation of ERAD pathway and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants58 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs10417824 | 19:1,009,365 | T/A | missense variant | — |
| rs1319721903 | 19:1,010,489 | C/T | — | uncertain significance |
| rs767740453 | 19:1,010,503 | A/G | — | uncertain significance |
| rs754750585 | 19:1,010,531 | G/A | — | uncertain significance |
| rs778582961 | 19:1,010,543 | G/C | — | uncertain significance |
| rs771672096 | 19:1,010,561 | C/T | — | uncertain significance |
| rs751530483 | 19:1,010,609 | C/T | — | likely benign |
| rs758058478 | 19:1,010,659 | G/A | — | uncertain significance |
| rs1386372356 | 19:1,010,675 | G/A | — | uncertain significance |
| rs749847410 | 19:1,010,681 | C/T | — | uncertain significance |
| rs527744500 | 19:1,010,690 | C/T | — | uncertain significance |
| rs541213100 | 19:1,010,699 | C/T | — | uncertain significance |
| rs1391082495 | 19:1,010,714 | G/T | — | uncertain significance |
| rs779554733 | 19:1,010,746 | G/A | — | uncertain significance |
| rs2038880756 | 19:1,010,749 | G/A | — | uncertain significance |
| rs564800791 | 19:1,010,782 | G/T | — | uncertain significance |
| rs202006160 | 19:1,010,836 | C/T | — | uncertain significance |
| rs752097768 | 19:1,010,837 | G/T | — | uncertain significance |
| rs1008352619 | 19:1,010,848 | A/G | — | uncertain significance |
| rs374342292 | 19:1,011,123 | G/A | — | uncertain significance |
| rs755111878 | 19:1,011,156 | T/C | — | uncertain significance |
| rs373785911 | 19:1,011,409 | C/T | — | uncertain significance |
| rs756042133 | 19:1,011,439 | G/A | — | uncertain significance |
| rs2512117794 | 19:1,011,482 | C/T | — | uncertain significance |
| rs375020540 | 19:1,011,598 | G/A | — | likely benign |
| rs979898481 | 19:1,011,615 | C/T | — | uncertain significance |
| rs533634735 | 19:1,011,773 | G/A | — | uncertain significance |
| rs774806886 | 19:1,011,914 | C/T | — | uncertain significance |
| rs984460731 | 19:1,011,942 | C/T | — | uncertain significance |
| rs1018242058 | 19:1,011,977 | C/T | — | uncertain significance |
| rs117246624 | 19:1,012,002 | A/G | regulatory region variant | — |
| rs2512124510 | 19:1,012,105 | C/A | — | uncertain significance |
| rs1171646700 | 19:1,012,119 | C/T | — | uncertain significance |
| rs774357289 | 19:1,012,179 | G/A | — | uncertain significance |
| rs757724979 | 19:1,012,480 | C/T | — | uncertain significance |
| rs760900356 | 19:1,013,251 | G/A | — | uncertain significance |
| rs1202195467 | 19:1,013,258 | G/C | — | uncertain significance |
| rs777585641 | 19:1,013,272 | T/C | — | uncertain significance |
| rs774689292 | 19:1,013,305 | G/A | — | uncertain significance |
| rs2512133304 | 19:1,013,310 | G/C | — | uncertain significance |
| rs2512138323 | 19:1,014,227 | C/G | — | uncertain significance |
| rs750149386 | 19:1,014,238 | C/T | — | uncertain significance |
| rs760384046 | 19:1,014,250 | T/C | — | likely benign |
| rs766043802 | 19:1,014,256 | G/C | — | uncertain significance |
| rs543348433 | 19:1,014,285 | G/A | — | uncertain significance |
| rs752192305 | 19:1,014,333 | G/T | — | uncertain significance |
| rs137931484 | 19:1,014,334 | C/T | — | uncertain significance |
| rs2512139538 | 19:1,014,339 | C/T | — | uncertain significance |
| rs200204634 | 19:1,014,393 | C/T | — | uncertain significance |
| rs370174847 | 19:1,014,423 | C/T | — | uncertain significance |
| rs2240170 | 19:1,019,105 | C/T | — | — |
| rs768401692 | 19:1,020,826 | G/A | — | uncertain significance |
| rs770285796 | 19:1,020,869 | G/C | — | uncertain significance |
| rs763283969 | 19:1,020,877 | A/C | — | uncertain significance |
| rs767495811 | 19:1,020,892 | T/G | — | uncertain significance |
| rs377599824 | 19:1,020,907 | G/A | — | uncertain significance |
| rs2512166556 | 19:1,020,984 | G/C | — | uncertain significance |
| rs117481827 | 19:1,021,627 | T/C | coding sequence variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.