TNFAIP6

TNF alpha induced protein 6

Summary

The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]

Known Variants17 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs10930576	2:152,212,156	C/A	upstream gene variant	—
rs766282193	2:152,214,211	C/G	—	uncertain significance
rs761269991	2:152,220,460	G/T	—	uncertain significance
rs1308388959	2:152,220,486	G/C	—	uncertain significance
rs566948911	2:152,220,490	G/T	—	uncertain significance
rs375585000	2:152,220,506	G/T	—	uncertain significance
rs138376471	2:152,220,555	C/G	—	uncertain significance
rs774746563	2:152,222,606	G/A	—	uncertain significance
rs77964389	2:152,225,719	C/A	upstream gene variant	—
rs144393744	2:152,226,541	G/C	—	uncertain significance
rs564029423	2:152,226,551	G/A	—	uncertain significance
rs1684789547	2:152,226,644	T/C	—	uncertain significance
rs780367746	2:152,226,654	G/A	—	likely benign
rs771155983	2:152,230,073	G/A	—	uncertain significance
rs774196085	2:152,235,952	A/G	—	likely benign
rs757631554	2:152,235,991	A/T	—	uncertain significance
rs183754548	2:152,238,019	A/G	regulatory region variant	—

Gene information from NCBI Gene. Variant classifications from ClinVar.