TNFRSF10B
TNF receptor superfamily member 10b
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Known Variants56 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1047275 | 8:22,880,162 | G/C | regulatory region variant | — |
| rs373566329 | 8:22,880,179 | C/A | — | likely benign |
| rs767491717 | 8:22,880,321 | C/T | — | uncertain significance |
| rs201130588 | 8:22,880,356 | G/A | — | uncertain significance |
| rs61756237 | 8:22,880,380 | G/A | — | uncertain significance |
| rs762446032 | 8:22,880,433 | C/T | — | uncertain significance |
| rs1811582115 | 8:22,880,459 | G/A | — | uncertain significance |
| rs753715279 | 8:22,880,462 | C/A | — | uncertain significance |
| rs1282621629 | 8:22,880,473 | A/C | — | uncertain significance |
| rs141021862 | 8:22,881,769 | G/A | — | uncertain significance |
| rs199909973 | 8:22,884,663 | C/T | — | uncertain significance |
| rs772479699 | 8:22,884,677 | A/G | — | likely benign |
| rs138851047 | 8:22,884,737 | G/T | — | uncertain significance |
| rs777384758 | 8:22,884,783 | C/G | — | uncertain significance |
| rs1105944 | 8:22,885,109 | A/G | intron variant | — |
| rs141856351 | 8:22,885,246 | G/A | — | likely benign |
| rs41308110 | 8:22,885,843 | C/T | — | uncertain significance |
| rs2487101741 | 8:22,885,847 | A/T | — | uncertain significance |
| rs779594561 | 8:22,885,855 | C/A | — | uncertain significance |
| rs771135483 | 8:22,885,907 | C/A | — | uncertain significance |
| rs142057242 | 8:22,885,915 | A/G | — | uncertain significance |
| rs141760693 | 8:22,885,935 | T/C | — | likely benign |
| rs1259347151 | 8:22,885,959 | G/A | — | likely benign |
| rs61756238 | 8:22,886,002 | G/A | missense variant | — |
| rs13265018 | 8:22,886,020 | A/G | missense variant | benign |
| rs139403599 | 8:22,886,063 | C/T | — | likely benign |
| rs150063854 | 8:22,886,068 | T/G | — | uncertain significance |
| rs1563307737 | 8:22,886,086 | T/C | — | uncertain significance |
| rs748667891 | 8:22,886,090 | C/T | — | likely benign |
| rs883429 | 8:22,886,818 | C/T | intron variant | — |
| rs751372067 | 8:22,887,138 | C/T | — | likely benign |
| rs142417651 | 8:22,887,192 | A/G | — | uncertain significance |
| rs546143707 | 8:22,887,206 | C/T | — | likely benign |
| rs746184118 | 8:22,887,240 | G/A | — | likely benign |
| rs4460370 | 8:22,887,608 | G/A | intron variant | — |
| rs748767310 | 8:22,888,276 | A/C | — | uncertain significance |
| rs1046229411 | 8:22,888,336 | T/C | — | likely benign |
| rs78553663 | 8:22,888,357 | A/G | — | likely benign |
| rs145675791 | 8:22,888,366 | G/A | — | likely benign |
| rs375730504 | 8:22,888,395 | G/A | — | likely benign |
| rs11785599 | 8:22,892,274 | T/C | intron variant | — |
| rs145177168 | 8:22,899,151 | A/C | intron variant | — |
| rs1047453628 | 8:22,900,663 | A/T | — | uncertain significance |
| rs1047266 | 8:22,900,701 | G/T | missense variant | benign |
| rs781307433 | 8:22,900,717 | C/T | — | uncertain significance |
| rs150192996 | 8:22,900,733 | G/A | — | likely benign |
| rs4259415 | 8:22,901,568 | A/C | intron variant | — |
| rs574808974 | 8:22,910,314 | G/T | — | — |
| rs527767423 | 8:22,921,323 | C/T | — | — |
| rs2486394509 | 8:22,926,279 | G/A | — | likely benign |
| rs1813079043 | 8:22,926,284 | C/T | — | uncertain significance |
| rs1129424 | 8:22,926,313 | G/A | missense variant | — |
| rs41308114 | 8:22,926,352 | C/T | — | benign |
| rs759200719 | 8:22,926,385 | G/A | — | uncertain significance |
| rs569815750 | 8:22,927,006 | G/A | — | — |
| rs78905543 | 8:22,927,017 | G/C | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.