TNFRSF21
TNF receptor superfamily member 21
Summary
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
Known Variants44 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs775271183 | 6:47,200,614 | G/A | — | uncertain significance |
| rs2481175526 | 6:47,202,509 | C/G | — | uncertain significance |
| rs114426615 | 6:47,202,518 | T/C | — | benign |
| rs1240415872 | 6:47,202,522 | G/A | — | uncertain significance |
| rs761074827 | 6:47,202,551 | C/A | — | uncertain significance |
| rs1267844279 | 6:47,202,575 | G/C | — | uncertain significance |
| rs749175419 | 6:47,202,577 | T/C | — | uncertain significance |
| rs540435757 | 6:47,214,894 | T/C | — | — |
| rs1764929141 | 6:47,221,006 | C/G | — | uncertain significance |
| rs1200134171 | 6:47,221,022 | C/G | — | uncertain significance |
| rs781439087 | 6:47,221,087 | C/T | — | uncertain significance |
| rs879028245 | 6:47,221,095 | C/T | — | uncertain significance |
| rs562437201 | 6:47,221,128 | C/T | — | uncertain significance |
| rs762869357 | 6:47,221,146 | T/C | — | uncertain significance |
| rs913267299 | 6:47,221,231 | C/A | — | uncertain significance |
| rs2103868 | 6:47,230,615 | A/T | — | — |
| rs139665387 | 6:47,251,686 | A/T | — | uncertain significance |
| rs774147091 | 6:47,251,707 | G/A | — | uncertain significance |
| rs115625609 | 6:47,251,758 | C/T | — | benign |
| rs764174748 | 6:47,251,805 | C/T | — | uncertain significance |
| rs776905566 | 6:47,251,806 | G/A | — | uncertain significance |
| rs201068310 | 6:47,251,827 | C/A | — | uncertain significance |
| rs775155357 | 6:47,251,895 | T/C | — | uncertain significance |
| rs2481249589 | 6:47,251,896 | G/A | — | uncertain significance |
| rs756711648 | 6:47,251,994 | T/C | — | uncertain significance |
| rs368556277 | 6:47,252,037 | T/A | — | uncertain significance |
| rs146578369 | 6:47,252,045 | G/A | — | uncertain significance |
| rs143637698 | 6:47,253,703 | G/C | — | uncertain significance |
| rs151242114 | 6:47,253,734 | G/A | — | uncertain significance |
| rs759167419 | 6:47,253,826 | T/G | — | uncertain significance |
| rs767858868 | 6:47,253,911 | G/A | — | uncertain significance |
| rs751726087 | 6:47,253,974 | C/A | — | uncertain significance |
| rs545509001 | 6:47,253,982 | A/G | — | uncertain significance |
| rs1762647125 | 6:47,253,983 | C/T | — | uncertain significance |
| rs369353250 | 6:47,253,992 | G/C | — | uncertain significance |
| rs549601816 | 6:47,254,004 | C/A | — | uncertain significance |
| rs766343276 | 6:47,254,079 | T/C | — | uncertain significance |
| rs754324198 | 6:47,254,121 | T/C | — | uncertain significance |
| rs1762649739 | 6:47,254,154 | G/T | — | uncertain significance |
| rs749130136 | 6:47,254,172 | G/A | — | uncertain significance |
| rs41305916 | 6:47,254,224 | G/A | — | benign |
| rs770693688 | 6:47,254,276 | A/G | — | uncertain significance |
| rs200394782 | 6:47,277,181 | C/A | — | likely benign |
| rs2481285919 | 6:47,277,219 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.