TNFRSF9
TNF receptor superfamily member 9
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
Known Variants129 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2151410080 | 1:7,980,900 | G/A | — | likely benign |
| rs776878260 | 1:7,980,914 | T/C | — | uncertain significance |
| rs759184548 | 1:7,980,923 | T/C | — | uncertain significance |
| rs554909019 | 1:7,980,932 | C/T | — | uncertain significance |
| rs1280784319 | 1:7,980,933 | G/A | — | uncertain significance |
| rs752191416 | 1:7,980,941 | C/T | — | uncertain significance |
| rs1024785003 | 1:7,980,956 | T/C | — | uncertain significance |
| rs141498457 | 1:7,980,968 | A/G | — | uncertain significance |
| rs750218461 | 1:7,980,970 | T/C | — | likely benign |
| rs1451970558 | 1:7,980,979 | A/G | — | likely benign |
| rs1361632057 | 1:7,980,990 | A/C | — | likely benign |
| rs755163910 | 1:7,980,991 | A/C | — | likely benign |
| rs543185072 | 1:7,980,995 | A/T | — | likely benign |
| rs778402646 | 1:7,980,996 | T/A | — | likely benign |
| rs161827 | 1:7,982,034 | T/C | — | benign |
| rs2453021 | 1:7,989,566 | C/T | intron variant | — |
| rs761700057 | 1:7,993,209 | A/G | — | likely benign |
| rs533883433 | 1:7,993,222 | G/A | — | uncertain significance |
| rs1639759465 | 1:7,993,233 | A/G | — | uncertain significance |
| rs1041338477 | 1:7,993,238 | C/T | — | likely benign |
| rs780812476 | 1:7,993,252 | T/C | — | uncertain significance |
| rs143524950 | 1:7,993,258 | G/A | — | uncertain significance |
| rs1227409963 | 1:7,993,269 | G/A | — | uncertain significance |
| rs1239035274 | 1:7,993,275 | C/T | — | uncertain significance |
| rs373493964 | 1:7,993,280 | C/A | — | likely benign |
| rs555723076 | 1:7,993,281 | G/A | — | uncertain significance |
| rs746242326 | 1:7,993,286 | G/A | — | uncertain significance |
| rs1397444895 | 1:7,993,292 | C/T | — | likely benign |
| rs770098625 | 1:7,993,296 | A/G | — | uncertain significance |
| rs143532137 | 1:7,993,307 | C/T | — | likely benign |
| rs376451216 | 1:7,993,313 | C/T | — | likely benign |
| rs192265662 | 1:7,993,322 | C/T | — | likely benign |
| rs753713618 | 1:7,993,325 | A/T | — | likely benign |
| rs758622644 | 1:7,993,330 | A/G | — | uncertain significance |
| rs2527260732 | 1:7,993,340 | G/T | — | likely benign |
| rs150424591 | 1:7,993,346 | C/T | — | likely benign |
| rs2151417795 | 1:7,993,357 | C/T | — | likely pathogenic |
| rs908519580 | 1:7,993,360 | C/A | — | likely benign |
| rs750945041 | 1:7,993,367 | C/T | — | likely benign |
| rs756670508 | 1:7,993,369 | G/C | — | likely benign |
| rs756512867 | 1:7,995,057 | G/A | — | likely benign |
| rs2527263953 | 1:7,995,065 | C/A | — | likely benign |
| rs1434417143 | 1:7,995,066 | C/A | — | likely benign |
| rs28360480 | 1:7,995,083 | C/T | — | likely benign |
| rs9657979 | 1:7,995,090 | G/T | — | benign |
| rs770976275 | 1:7,995,095 | C/T | — | likely benign |
| rs776774122 | 1:7,995,096 | G/A | — | uncertain significance |
| rs2527264108 | 1:7,995,107 | G/A | — | likely benign |
| rs144772280 | 1:7,995,111 | G/A | — | uncertain significance |
| rs148554600 | 1:7,995,116 | C/T | — | likely benign |
| rs145966863 | 1:7,995,117 | G/A | — | uncertain significance |
| rs766869142 | 1:7,995,123 | A/G | — | uncertain significance |
| rs780480575 | 1:7,995,128 | G/A | — | likely benign |
| rs1289916547 | 1:7,995,151 | C/T | — | uncertain significance |
| rs373859958 | 1:7,995,152 | G/A | — | likely benign |
| rs781254753 | 1:7,995,163 | T/C | — | uncertain significance |
| rs577769421 | 1:7,995,164 | C/T | — | likely benign |
| rs769884031 | 1:7,995,165 | G/A | — | uncertain significance |
| rs1639798382 | 1:7,995,167 | C/T | — | likely benign |
| rs1342683475 | 1:7,995,170 | A/G | — | uncertain significance |
| rs1220227331 | 1:7,995,184 | A/C | — | uncertain significance |
| rs2527264558 | 1:7,995,189 | C/G | — | uncertain significance |
| rs1578076558 | 1:7,995,192 | T/A | — | uncertain significance |
| rs901862166 | 1:7,995,196 | A/G | — | likely benign |
| rs1329460607 | 1:7,995,207 | A/G | — | likely benign |
| rs226478 | 1:7,996,634 | A/G | — | benign |
| rs2527269480 | 1:7,997,730 | C/A | — | likely benign |
| rs780100518 | 1:7,997,742 | A/G | — | likely benign |
| rs373663685 | 1:7,997,746 | G/A | — | uncertain significance |
| rs1639840705 | 1:7,997,748 | A/G | — | likely pathogenic |
| rs2527269580 | 1:7,997,758 | G/A | — | likely benign |
| rs186372948 | 1:7,997,762 | C/T | — | uncertain significance |
| rs771142611 | 1:7,997,763 | G/A | — | pathogenic |
| rs1639841108 | 1:7,997,775 | G/A | — | uncertain significance |
| rs2527269651 | 1:7,997,782 | A/G | — | likely benign |
| rs765656918 | 1:7,997,785 | G/A | — | likely benign |
| rs763203873 | 1:7,997,808 | C/G | — | uncertain significance |
| rs752004630 | 1:7,997,816 | C/G | — | uncertain significance |
| rs1344028820 | 1:7,997,829 | A/T | — | likely benign |
| rs761491259 | 1:7,997,831 | G/T | — | likely benign |
| rs767292376 | 1:7,997,834 | A/G | — | likely benign |
| rs564756998 | 1:7,997,836 | C/A | — | likely benign |
| rs371929562 | 1:7,998,242 | C/T | — | likely benign |
| rs754883091 | 1:7,998,243 | G/A | — | likely benign |
| rs376214771 | 1:7,998,248 | C/T | — | uncertain significance |
| rs9657966 | 1:7,998,249 | G/C | — | uncertain significance |
| rs9657965 | 1:7,998,254 | T/G | — | likely benign |
| rs2527270851 | 1:7,998,274 | C/T | — | uncertain significance |
| rs147680622 | 1:7,998,277 | G/C | — | uncertain significance |
| rs2527270896 | 1:7,998,289 | G/A | — | pathogenic |
| rs146308127 | 1:7,998,308 | T/C | — | benign |
| rs759034075 | 1:7,998,313 | C/G | — | uncertain significance |
| rs1639851898 | 1:7,998,324 | A/C | — | uncertain significance |
| rs765127482 | 1:7,998,326 | C/T | — | likely benign |
| rs2527271035 | 1:7,998,333 | G/A | — | uncertain significance |
| rs752678621 | 1:7,998,334 | T/G | — | uncertain significance |
| rs763838333 | 1:7,998,354 | C/T | — | uncertain significance |
| rs2151420079 | 1:7,998,384 | A/G | — | uncertain significance |
| rs202220858 | 1:7,998,390 | C/T | — | uncertain significance |
| rs544728592 | 1:7,998,394 | C/T | — | likely benign |
Showing 100 of 129 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.