TNFSF12

TNF superfamily member 12

Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]

Known Variants192 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7729490217:7,452,078G/C——
rs156771956717:7,452,476C/G—likely benign
rs250830379817:7,452,481G/C—uncertain significance
rs95878907017:7,452,493G/A—uncertain significance
rs121132215617:7,452,496G/A—uncertain significance
rs91249775017:7,452,499G/C—uncertain significance
rs207096861517:7,452,505G/C—uncertain significance
rs143222243517:7,452,508G/A—uncertain significance
rs117076370317:7,452,512G/A—likely benign
rs76806176817:7,452,513G/A—uncertain significance
rs215090400417:7,452,516C/A—uncertain significance
rs118887594717:7,452,521C/A—likely benign
rs141179342417:7,452,524C/T—likely benign
rs207096937617:7,452,525G/A—uncertain significance
rs130449472817:7,452,529T/C—uncertain significance
rs89849051217:7,452,530G/T—likely benign
rs141304959317:7,452,534G/C—uncertain significance
rs75309815117:7,452,538C/T—uncertain significance
rs130090817917:7,452,539G/A—likely benign
rs7771185517:7,452,542C/T—benign
rs104700164517:7,452,550G/T—uncertain significance
rs207097028317:7,452,557C/T—likely benign
rs123064339617:7,452,558C/G—uncertain significance
rs159782247217:7,452,560G/A—likely benign
rs148444834917:7,452,563G/A—likely benign
rs250830530817:7,452,566G/A—likely benign
rs90843855517:7,452,575C/G—likely benign
rs207097074317:7,452,576G/A—uncertain significance
rs215090407417:7,452,578C/T—likely benign
rs75667172917:7,452,579C/T—uncertain significance
rs117425093817:7,452,590C/T—likely benign
rs215090409017:7,452,598G/A—uncertain significance
rs207097113217:7,452,604G/A—uncertain significance
rs138639652217:7,452,607G/C—uncertain significance
rs100305517217:7,452,609C/T—uncertain significance
rs116772640117:7,452,611G/T—likely benign
rs136869859417:7,452,612G/C—uncertain significance
rs141156441117:7,452,613C/T—uncertain significance
rs103623288517:7,452,617G/A—likely benign
rs207097158717:7,452,624G/A—uncertain significance
rs53227155917:7,452,627C/A—uncertain significance
rs101312102717:7,452,632G/A—uncertain significance
rs20057510217:7,452,634G/C—uncertain significance
rs53584001717:7,452,636C/A—likely benign
rs105128677817:7,452,640G/T—likely benign
rs127433940017:7,452,644C/T—likely benign
rs8006737217:7,452,752G/A—benign
rs13799469417:7,452,772G/A—benign
rs123660805017:7,452,775C/T—likely benign
rs14947517917:7,452,777C/T—likely benign
rs76471853317:7,452,795C/T—uncertain significance
rs86868735217:7,452,808G/C—uncertain significance
rs215090425417:7,452,817A/G—likely benign
rs250830799217:7,452,818G/A—uncertain significance
rs75809091717:7,452,821G/A—uncertain significance
rs74701997317:7,452,825A/C—uncertain significance
rs131814325417:7,452,827C/T—uncertain significance
rs139030310517:7,452,828A/G—uncertain significance
rs143780980317:7,452,832C/A—uncertain significance
rs75138144217:7,452,835G/A—benign
rs250830831917:7,452,841G/C—uncertain significance
rs78119626717:7,452,848C/T—likely benign
rs126654012317:7,452,849G/A—likely benign
rs207097584517:7,452,852G/A—likely benign
rs53496936117:7,452,855G/A—likely benign
rs76975775517:7,452,856C/T—likely benign
rs148212938817:7,452,857G/A—likely benign
rs76574851217:7,453,418C/G—likely benign
rs250831296517:7,453,422C/T—likely benign
rs215090464217:7,453,429T/A—likely benign
rs207098366217:7,453,430C/G—likely benign
rs207098379317:7,453,434T/C—uncertain significance
rs215090465717:7,453,448C/G—likely benign
rs207098400617:7,453,451G/C—uncertain significance
rs99668909117:7,453,471C/T—uncertain significance
rs75114864217:7,453,472T/C—likely benign
rs37008506917:7,453,474C/T—uncertain significance
rs207098440617:7,453,475G/A—likely benign
rs250831331717:7,453,476C/A—uncertain significance
rs76727532017:7,453,478T/C—likely benign
rs207098455517:7,453,487C/T—likely benign
rs250831340617:7,453,488C/T—uncertain significance
rs207098474217:7,453,495T/C—uncertain significance
rs74596742617:7,453,498G/A—uncertain significance
rs75849257117:7,453,503C/T—uncertain significance
rs6205980417:7,453,505C/A—benign
rs207099202317:7,454,113C/T—uncertain significance
rs118706185017:7,454,116C/A—uncertain significance
rs116959251817:7,454,120T/G—likely benign
rs74847947517:7,454,127C/T—uncertain significance
rs77013172717:7,454,128G/A—uncertain significance
rs15081616417:7,454,136C/T—uncertain significance
rs74985356117:7,454,137G/A—uncertain significance
rs143270377517:7,454,142C/T—uncertain significance
rs132699309317:7,454,144A/G—likely benign
rs77164393617:7,454,148G/A—uncertain significance
rs36985198517:7,454,149C/T—uncertain significance
rs76404577417:7,454,150G/A—likely benign
rs13964260017:7,454,153C/T—likely benign
rs146325977917:7,454,155C/T—uncertain significance

Showing 100 of 192 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.