TNIK

TRAF2 and NCK interacting kinase

Summary

Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

Known Variants107 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs771977662	3:170,781,695	T/C	—	uncertain significance
rs1718470837	3:170,784,381	T/C	—	likely benign
rs375464687	3:170,784,390	T/C	—	likely benign
rs764331012	3:170,784,415	C/T	—	uncertain significance
rs2473388386	3:170,784,430	A/G	—	uncertain significance
rs1057520155	3:170,784,517	C/T	—	uncertain significance
rs573971000	3:170,789,036	C/T	—	benign
rs192304760	3:170,789,119	T/A	—	benign
rs747724436	3:170,797,327	C/T	—	uncertain significance
rs369408271	3:170,800,073	G/A	—	likely benign
rs55899038	3:170,800,128	C/T	—	likely benign
rs61736291	3:170,802,101	G/A	—	likely benign
rs2473482316	3:170,802,909	G/A	—	uncertain significance
rs17857452	3:170,802,910	C/T	—	benign
rs368574578	3:170,802,911	G/A	—	likely benign
rs761360121	3:170,802,913	C/T	—	uncertain significance
rs1235362593	3:170,802,932	T/G	—	uncertain significance
rs753162293	3:170,802,953	C/T	—	likely benign
rs200347488	3:170,805,148	T/C	—	uncertain significance
rs373326278	3:170,805,245	A/T	—	likely benign
rs777027009	3:170,805,255	T/C	—	uncertain significance
rs1047175357	3:170,805,262	C/G	—	uncertain significance
rs762006959	3:170,805,276	C/T	—	uncertain significance
rs1340420482	3:170,805,280	T/G	—	uncertain significance
rs35090763	3:170,805,288	C/T	—	uncertain significance
rs377530882	3:170,805,293	C/A	—	uncertain significance
rs192746498	3:170,811,629	T/G	—	likely benign
rs1560099380	3:170,811,638	A/C	—	uncertain significance
rs16855789	3:170,811,667	G/A	—	benign
rs368871345	3:170,811,680	G/A	—	uncertain significance
rs750241181	3:170,811,702	G/A	—	uncertain significance
rs1371767588	3:170,811,708	C/T	—	uncertain significance
rs367912923	3:170,819,254	C/T	—	uncertain significance
rs900629577	3:170,819,255	G/C	—	uncertain significance
rs779370298	3:170,819,270	C/T	—	benign
rs772479325	3:170,819,278	G/A	—	uncertain significance
rs1176265873	3:170,819,305	C/G	—	uncertain significance
rs775152419	3:170,819,309	C/G	—	likely benign
rs368910931	3:170,819,350	T/C	—	uncertain significance
rs201399947	3:170,819,367	C/T	—	uncertain significance
rs749170308	3:170,819,373	G/T	—	uncertain significance
rs1277841864	3:170,819,413	C/T	—	uncertain significance
rs753856105	3:170,825,871	G/A	—	uncertain significance
rs766186062	3:170,825,892	C/G	—	uncertain significance
rs6444960	3:170,825,905	G/C	—	benign
rs2291900	3:170,825,920	A/G	—	benign
rs1228652583	3:170,825,945	C/T	—	uncertain significance
rs199741418	3:170,825,959	A/G	—	likely benign
rs2473635484	3:170,828,572	G/A	—	uncertain significance
rs372553452	3:170,828,652	C/T	—	uncertain significance
rs11920719	3:170,834,559	A/C	regulatory region variant	—
rs1438536076	3:170,841,406	C/T	—	uncertain significance
rs139405029	3:170,841,480	T/C	—	likely benign
rs202161463	3:170,843,757	T/A	—	uncertain significance
rs779298053	3:170,843,807	G/A	—	uncertain significance
rs748021676	3:170,843,818	G/A	—	likely benign
rs368779668	3:170,843,833	G/A	—	likely benign
rs779458498	3:170,843,896	G/A	—	likely benign
rs368677789	3:170,846,554	A/G	—	likely benign
rs200431570	3:170,846,643	G/A	—	uncertain significance
rs766695626	3:170,846,657	C/T	—	uncertain significance
rs1183006011	3:170,846,676	C/A	—	likely benign
rs759740584	3:170,856,030	G/C	—	uncertain significance
rs61740073	3:170,856,055	C/T	—	likely benign
rs2473787970	3:170,856,146	T/C	—	uncertain significance
rs6444965	3:170,857,240	C/T	—	benign
rs759603578	3:170,857,282	G/A	—	likely benign
rs948588947	3:170,857,350	A/G	—	uncertain significance
rs376653606	3:170,858,208	T/G	—	likely benign
rs376964973	3:170,858,248	G/A	—	likely benign
rs9810566	3:170,870,978	C/G	—	—
rs754103722	3:170,875,267	C/G	—	uncertain significance
rs367602557	3:170,875,303	G/A	—	likely benign
rs769554958	3:170,875,353	G/C	—	uncertain significance
rs370221102	3:170,875,415	C/A	—	uncertain significance
rs2473885885	3:170,875,449	T/C	—	uncertain significance
rs1577004170	3:170,879,070	T/C	—	likely benign
rs372170027	3:170,884,876	C/T	—	likely benign
rs180780206	3:170,884,881	A/C	—	likely benign
rs762209843	3:170,884,967	A/G	—	uncertain significance
rs1424363770	3:170,885,032	C/G	—	uncertain significance
rs111810473	3:170,893,064	C/T	—	benign
rs12637875	3:170,893,070	A/G	—	benign
rs756602396	3:170,893,113	C/G	—	uncertain significance
rs1577072202	3:170,906,578	C/T	—	likely benign
rs886037841	3:170,906,592	G/A	stop gained	pathogenic
rs192028546	3:170,908,481	C/G	—	uncertain significance
rs201897939	3:170,908,586	T/C	—	benign
rs6444970	3:170,910,442	T/A	—	—
rs141160238	3:170,912,303	T/G	—	likely benign
rs544226799	3:170,928,940	T/G	—	uncertain significance
rs2474121919	3:170,928,960	G/A	—	uncertain significance
rs142911215	3:170,945,981	T/C	—	benign
rs76246285	3:170,946,028	T/C	—	likely benign
rs2088885	3:170,971,291	C/A	intron variant	—
rs6444974	3:170,986,411	G/A	intron variant	—
rs112438212	3:170,993,543	G/A	intron variant	—
rs61401141	3:171,000,137	T/G	regulatory region variant	—
rs183433223	3:171,001,457	C/T	intron variant	—
rs13092687	3:171,015,391	C/T	intron variant	—

Showing 100 of 107 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.