TNKS
tankyrase
Summary
Enables histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Involved in several processes, including positive regulation of canonical Wnt signaling pathway; post-translational protein modification; and regulation of chromosome organization. Acts upstream of or within peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Located in several cellular components, including chromosome, telomeric region; mitotic spindle pole; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants84 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs6990097 | 8:9,412,857 | T/C | coding sequence variant | — |
| rs1302984680 | 8:9,413,457 | C/A | — | uncertain significance |
| rs200583768 | 8:9,413,476 | T/A | — | uncertain significance |
| rs953371596 | 8:9,413,480 | C/T | — | uncertain significance |
| rs1815266339 | 8:9,413,507 | C/G | — | uncertain significance |
| rs1248874882 | 8:9,413,516 | G/C | — | uncertain significance |
| rs2486225695 | 8:9,413,520 | C/T | — | uncertain significance |
| rs566458697 | 8:9,413,552 | C/G | — | uncertain significance |
| rs538675433 | 8:9,413,571 | C/T | — | uncertain significance |
| rs754746323 | 8:9,413,573 | G/C | — | uncertain significance |
| rs1344566634 | 8:9,413,615 | T/G | — | uncertain significance |
| rs1815278595 | 8:9,413,622 | C/G | — | uncertain significance |
| rs1815282283 | 8:9,413,655 | A/G | — | uncertain significance |
| rs759679641 | 8:9,413,679 | G/A | — | uncertain significance |
| rs146118607 | 8:9,413,688 | C/T | — | uncertain significance |
| rs2486227446 | 8:9,413,720 | A/G | — | uncertain significance |
| rs373323688 | 8:9,413,723 | A/G | — | uncertain significance |
| rs139926450 | 8:9,413,734 | A/T | — | benign |
| rs376761478 | 8:9,413,745 | T/G | — | uncertain significance |
| rs531198224 | 8:9,413,807 | C/G | — | uncertain significance |
| rs1428199985 | 8:9,413,873 | T/C | — | uncertain significance |
| rs147674490 | 8:9,413,876 | C/G | — | uncertain significance |
| rs35433754 | 8:9,413,893 | G/A | — | benign |
| rs1263029329 | 8:9,413,896 | C/G | — | uncertain significance |
| rs370539656 | 8:9,413,907 | G/A | — | uncertain significance |
| rs763470149 | 8:9,414,036 | C/G | — | uncertain significance |
| rs10103970 | 8:9,428,673 | T/C | intron variant | — |
| rs59517107 | 8:9,437,664 | T/C | — | benign |
| rs1384754091 | 8:9,437,706 | G/T | — | uncertain significance |
| rs773491393 | 8:9,437,728 | C/T | — | uncertain significance |
| rs2486320832 | 8:9,437,791 | A/C | — | uncertain significance |
| rs772466595 | 8:9,437,848 | C/T | — | uncertain significance |
| rs747186492 | 8:9,437,861 | C/G | — | uncertain significance |
| rs10093972 | 8:9,451,369 | T/C | intron variant | — |
| rs10104247 | 8:9,465,186 | A/G | — | — |
| rs201384024 | 8:9,473,106 | G/A | — | uncertain significance |
| rs7846399 | 8:9,493,129 | T/C | intron variant | — |
| rs11249932 | 8:9,500,244 | A/C | — | — |
| rs6985140 | 8:9,537,427 | A/G | intron variant | — |
| rs953454858 | 8:9,538,240 | G/A | — | uncertain significance |
| rs61756245 | 8:9,538,250 | A/G | — | benign |
| rs1462401273 | 8:9,538,261 | C/A | — | uncertain significance |
| rs10903317 | 8:9,555,907 | A/C | intron variant | — |
| rs35233861 | 8:9,558,447 | T/A | — | — |
| rs2486393221 | 8:9,562,176 | A/T | — | uncertain significance |
| rs777314477 | 8:9,562,213 | G/A | — | uncertain significance |
| rs35809238 | 8:9,564,511 | C/T | — | benign |
| rs998790285 | 8:9,565,952 | G/A | — | uncertain significance |
| rs117157809 | 8:9,566,882 | T/C | intron variant | — |
| rs1448765122 | 8:9,567,525 | A/G | — | uncertain significance |
| rs1358718006 | 8:9,567,690 | A/G | — | uncertain significance |
| rs201404312 | 8:9,577,884 | A/T | — | uncertain significance |
| rs769652034 | 8:9,578,029 | A/G | — | uncertain significance |
| rs1043487769 | 8:9,588,487 | G/A | — | uncertain significance |
| rs2486493820 | 8:9,588,530 | A/G | — | uncertain significance |
| rs34016764 | 8:9,590,943 | C/A | — | uncertain significance |
| rs61752022 | 8:9,592,392 | T/C | — | likely benign |
| rs1348030210 | 8:9,592,490 | C/T | — | uncertain significance |
| rs147259455 | 8:9,592,535 | C/T | — | uncertain significance |
| rs192449459 | 8:9,592,900 | C/G | — | uncertain significance |
| rs2486511750 | 8:9,592,911 | C/G | — | uncertain significance |
| rs12545912 | 8:9,601,699 | G/A | — | — |
| rs373055237 | 8:9,605,702 | A/G | — | uncertain significance |
| rs4840437 | 8:9,606,264 | G/T | — | — |
| rs35341965 | 8:9,607,941 | C/T | intron variant | — |
| rs1236365762 | 8:9,609,158 | C/T | — | uncertain significance |
| rs149754939 | 8:9,609,234 | C/T | — | uncertain significance |
| rs114570088 | 8:9,609,235 | C/T | — | benign |
| rs779623470 | 8:9,609,284 | G/A | — | uncertain significance |
| rs754671042 | 8:9,609,345 | A/G | — | uncertain significance |
| rs759273752 | 8:9,610,090 | A/C | — | uncertain significance |
| rs6989782 | 8:9,610,538 | C/G | — | — |
| rs753415514 | 8:9,619,135 | G/A | — | uncertain significance |
| rs566448141 | 8:9,620,675 | C/G | — | uncertain significance |
| rs764654135 | 8:9,620,683 | T/C | — | uncertain significance |
| rs1380278827 | 8:9,623,222 | G/C | — | uncertain significance |
| rs143138820 | 8:9,623,224 | A/G | — | uncertain significance |
| rs1807401746 | 8:9,623,242 | G/A | — | uncertain significance |
| rs907467819 | 8:9,623,761 | T/C | — | uncertain significance |
| rs2486631069 | 8:9,623,833 | A/G | — | uncertain significance |
| rs750536925 | 8:9,627,639 | C/T | — | uncertain significance |
| rs2486649933 | 8:9,627,672 | T/C | — | uncertain significance |
| rs376965971 | 8:9,634,220 | G/A | — | uncertain significance |
| rs74891397 | 8:9,640,026 | G/A | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.