TOPBP1
DNA topoisomerase II binding protein 1
Summary
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]
Known Variants111 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs112843513 | 3:133,319,574 | — | — | — |
| rs116195487 | 3:133,319,834 | G/C | 3 prime UTR variant | — |
| rs115160714 | 3:133,319,865 | G/A | 3 prime UTR variant | — |
| rs116645643 | 3:133,319,878 | T/C | 3 prime UTR variant | — |
| rs185903567 | 3:133,319,974 | C/T | 3 prime UTR variant | — |
| rs1234695941 | 3:133,320,113 | T/C | — | uncertain significance |
| rs1294965420 | 3:133,320,121 | A/T | — | uncertain significance |
| rs1217981986 | 3:133,320,129 | C/G | — | uncertain significance |
| rs2530071700 | 3:133,320,164 | C/T | — | uncertain significance |
| rs2530071826 | 3:133,320,186 | T/A | — | uncertain significance |
| rs375720264 | 3:133,320,203 | G/A | — | uncertain significance |
| rs2530071930 | 3:133,320,210 | A/G | — | uncertain significance |
| rs1282660552 | 3:133,327,404 | T/A | — | uncertain significance |
| rs1934569931 | 3:133,327,407 | G/T | — | uncertain significance |
| rs753747683 | 3:133,327,419 | T/C | — | uncertain significance |
| rs148403666 | 3:133,327,432 | C/A | — | benign |
| rs1051772 | 3:133,327,457 | T/C | — | benign |
| rs779262980 | 3:133,329,869 | T/G | — | uncertain significance |
| rs1315899716 | 3:133,329,911 | T/G | — | likely benign |
| rs779755916 | 3:133,329,920 | T/C | — | likely benign |
| rs372486861 | 3:133,329,964 | T/A | — | uncertain significance |
| rs71317417 | 3:133,331,230 | C/T | — | benign |
| rs377714715 | 3:133,331,261 | G/C | — | uncertain significance |
| rs774140168 | 3:133,331,276 | C/T | — | uncertain significance |
| rs780031847 | 3:133,335,690 | C/T | — | uncertain significance |
| rs2530122129 | 3:133,335,712 | A/G | — | uncertain significance |
| rs912679926 | 3:133,335,762 | G/A | — | uncertain significance |
| rs773409775 | 3:133,336,029 | G/A | — | uncertain significance |
| rs201221333 | 3:133,336,030 | G/C | — | uncertain significance |
| rs753874548 | 3:133,337,060 | G/C | — | uncertain significance |
| rs201713746 | 3:133,337,092 | T/C | — | uncertain significance |
| rs375694192 | 3:133,337,110 | A/G | — | uncertain significance |
| rs2530130302 | 3:133,337,188 | C/T | — | uncertain significance |
| rs1412888468 | 3:133,337,252 | C/T | — | likely benign |
| rs138529143 | 3:133,338,990 | G/A | — | conflicting classifications of pathogenicity |
| rs376993388 | 3:133,339,042 | G/A | — | uncertain significance |
| rs370120696 | 3:133,339,066 | C/T | — | uncertain significance |
| rs368014076 | 3:133,339,120 | T/C | — | uncertain significance |
| rs756468553 | 3:133,339,161 | T/C | — | uncertain significance |
| rs764484746 | 3:133,339,179 | G/C | — | uncertain significance |
| rs2530156480 | 3:133,341,980 | C/T | — | uncertain significance |
| rs10935070 | 3:133,341,988 | C/T | — | benign |
| rs754509414 | 3:133,342,003 | T/C | — | uncertain significance |
| rs755762254 | 3:133,342,145 | T/C | — | likely benign |
| rs768785490 | 3:133,342,190 | G/C | — | uncertain significance |
| rs61758061 | 3:133,342,192 | T/C | — | benign |
| rs369186269 | 3:133,342,208 | G/A | — | uncertain significance |
| rs4854738 | 3:133,342,218 | T/C | — | benign |
| rs79533362 | 3:133,342,223 | C/A | — | uncertain significance |
| rs1559814625 | 3:133,342,255 | G/A | — | uncertain significance |
| rs781165125 | 3:133,342,277 | G/A | — | uncertain significance |
| rs1408096781 | 3:133,342,290 | C/G | — | uncertain significance |
| rs555995953 | 3:133,342,913 | C/T | — | uncertain significance |
| rs201768751 | 3:133,342,945 | G/T | — | uncertain significance |
| rs762718182 | 3:133,342,957 | C/T | — | uncertain significance |
| rs61748108 | 3:133,347,211 | A/G | — | likely benign |
| rs750736959 | 3:133,347,231 | C/G | — | uncertain significance |
| rs376799164 | 3:133,347,477 | G/A | — | uncertain significance |
| rs764639160 | 3:133,347,501 | A/G | — | uncertain significance |
| rs201984734 | 3:133,347,516 | G/A | — | uncertain significance |
| rs373196410 | 3:133,347,520 | T/G | — | uncertain significance |
| rs1160830504 | 3:133,347,535 | G/C | — | uncertain significance |
| rs192653358 | 3:133,347,546 | C/T | — | likely benign |
| rs746676815 | 3:133,347,547 | G/A | — | likely benign |
| rs17301766 | 3:133,356,790 | G/A | — | benign |
| rs2530228157 | 3:133,356,845 | C/G | — | uncertain significance |
| rs933367987 | 3:133,356,867 | G/C | — | uncertain significance |
| rs777480724 | 3:133,356,908 | C/T | — | likely benign |
| rs1227419282 | 3:133,356,916 | T/C | — | uncertain significance |
| rs1028890818 | 3:133,358,950 | T/C | — | likely benign |
| rs751568442 | 3:133,358,988 | G/C | — | uncertain significance |
| rs2530255917 | 3:133,362,153 | G/A | — | uncertain significance |
| rs17301889 | 3:133,362,154 | A/G | — | benign |
| rs542112041 | 3:133,362,194 | G/C | — | uncertain significance |
| rs1365550343 | 3:133,362,892 | A/G | — | uncertain significance |
| rs1296156323 | 3:133,362,905 | C/T | — | uncertain significance |
| rs2530260749 | 3:133,362,910 | C/T | — | uncertain significance |
| rs1935995827 | 3:133,363,012 | T/C | — | uncertain significance |
| rs374328158 | 3:133,363,176 | A/C | — | uncertain significance |
| rs1936202496 | 3:133,368,271 | T/C | — | uncertain significance |
| rs752452641 | 3:133,368,283 | T/G | — | uncertain significance |
| rs370936914 | 3:133,368,292 | C/T | — | likely benign |
| rs1936204715 | 3:133,368,314 | A/G | — | uncertain significance |
| rs139175445 | 3:133,368,340 | A/G | — | uncertain significance |
| rs1167225501 | 3:133,368,353 | T/C | — | uncertain significance |
| rs774002775 | 3:133,368,358 | G/C | — | uncertain significance |
| rs1425608081 | 3:133,368,400 | T/C | — | uncertain significance |
| rs1173196449 | 3:133,368,407 | A/G | — | uncertain significance |
| rs761563434 | 3:133,368,649 | G/T | — | uncertain significance |
| rs377100155 | 3:133,368,704 | C/G | — | uncertain significance |
| rs749743222 | 3:133,368,734 | A/T | — | likely benign |
| rs763168700 | 3:133,368,775 | C/T | — | uncertain significance |
| rs200397840 | 3:133,368,787 | T/C | — | uncertain significance |
| rs770675095 | 3:133,371,309 | G/A | — | uncertain significance |
| rs941876515 | 3:133,371,342 | A/G | — | uncertain significance |
| rs199552139 | 3:133,371,423 | C/A | — | uncertain significance |
| rs55633281 | 3:133,371,471 | A/G | — | benign |
| rs766779307 | 3:133,372,212 | G/C | — | uncertain significance |
| rs2530308528 | 3:133,372,306 | C/T | — | uncertain significance |
| rs2530308818 | 3:133,372,348 | T/C | — | uncertain significance |
Showing 100 of 111 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.