TPGS1
tubulin polyglutamylase complex subunit 1
Summary
Predicted to enable microtubule binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including adult behavior; chemical synaptic transmission; and protein polyglutamylation. Located in centrosome. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants36 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1408051572 | 19:507,513 | G/A | — | uncertain significance |
| rs370127539 | 19:507,545 | G/A | — | benign |
| rs754819631 | 19:507,597 | G/A | — | likely benign |
| rs551689110 | 19:507,611 | G/C | — | uncertain significance |
| rs2512361541 | 19:507,625 | G/A | — | uncertain significance |
| rs371899130 | 19:507,641 | G/A | — | likely benign |
| rs769086372 | 19:507,651 | C/T | — | uncertain significance |
| rs537230252 | 19:507,655 | C/T | — | uncertain significance |
| rs776657651 | 19:507,705 | C/G | — | uncertain significance |
| rs1199610913 | 19:507,766 | C/T | — | uncertain significance |
| rs1978667471 | 19:507,787 | A/G | — | uncertain significance |
| rs4919908 | 19:508,626 | C/T | downstream gene variant | — |
| rs4919910 | 19:509,717 | C/A | — | — |
| rs75796563 | 19:513,697 | C/T | intron variant | — |
| rs1241699243 | 19:518,893 | G/A | — | uncertain significance |
| rs752029125 | 19:518,896 | T/A | — | uncertain significance |
| rs781277634 | 19:518,900 | A/G | — | uncertain significance |
| rs373085894 | 19:518,914 | G/T | — | uncertain significance |
| rs1568324054 | 19:518,921 | A/G | — | uncertain significance |
| rs760194556 | 19:518,945 | G/C | — | uncertain significance |
| rs374059871 | 19:518,967 | C/G | — | uncertain significance |
| rs370581139 | 19:518,982 | C/T | — | benign |
| rs756398150 | 19:518,995 | C/A | — | uncertain significance |
| rs376974794 | 19:519,064 | G/C | — | uncertain significance |
| rs977642178 | 19:519,098 | C/T | — | uncertain significance |
| rs761101956 | 19:519,194 | G/T | — | uncertain significance |
| rs574484899 | 19:519,217 | G/T | — | uncertain significance |
| rs2512368642 | 19:519,244 | A/T | — | uncertain significance |
| rs1979075325 | 19:519,284 | C/G | — | uncertain significance |
| rs939153316 | 19:519,319 | G/A | — | uncertain significance |
| rs564681989 | 19:519,324 | C/T | — | likely benign |
| rs919143505 | 19:519,332 | G/C | — | uncertain significance |
| rs112370786 | 19:519,336 | G/A | — | benign |
| rs1201495209 | 19:519,340 | C/G | — | uncertain significance |
| rs550238099 | 19:519,341 | G/T | — | likely benign |
| rs1316763568 | 19:519,349 | G/A | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.