TPX2
TPX2 microtubule nucleation factor
Summary
Enables importin-alpha family protein binding activity; molecular adaptor activity; and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule cytoskeleton organization; and negative regulation of microtubule depolymerization. Located in intercellular bridge; nucleoplasm; and spindle. Is active in spindle. [provided by Alliance of Genome Resources, Apr 2025]
Known Variants47 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs6060912 | 20:30,325,755 | C/A | upstream gene variant | — |
| rs6087775 | 20:30,325,765 | G/A | upstream gene variant | — |
| rs781554900 | 20:30,345,320 | C/T | — | uncertain significance |
| rs1329073564 | 20:30,345,355 | G/A | — | uncertain significance |
| rs201478518 | 20:30,347,923 | G/A | — | uncertain significance |
| rs115949457 | 20:30,354,411 | C/T | — | benign |
| rs745355855 | 20:30,354,451 | G/A | — | likely benign |
| rs769150205 | 20:30,354,454 | A/G | — | uncertain significance |
| rs142491998 | 20:30,358,252 | C/G | — | uncertain significance |
| rs6089067 | 20:30,358,894 | G/T | — | — |
| rs58399677 | 20:30,359,429 | A/G | — | benign |
| rs368452660 | 20:30,359,457 | C/T | — | uncertain significance |
| rs2515385459 | 20:30,363,697 | G/T | — | uncertain significance |
| rs145341306 | 20:30,363,746 | C/T | — | uncertain significance |
| rs141564051 | 20:30,365,359 | G/A | — | uncertain significance |
| rs201973506 | 20:30,365,386 | A/G | — | uncertain significance |
| rs1162702706 | 20:30,365,392 | A/G | — | uncertain significance |
| rs776364959 | 20:30,365,427 | C/T | — | uncertain significance |
| rs565058479 | 20:30,366,657 | C/A | — | uncertain significance |
| rs376115422 | 20:30,366,731 | A/C | — | likely benign |
| rs201500640 | 20:30,366,763 | T/A | — | uncertain significance |
| rs6060941 | 20:30,367,383 | C/T | intron variant | — |
| rs6058462 | 20:30,367,674 | C/T | intron variant | — |
| rs113818546 | 20:30,369,090 | C/T | intron variant | — |
| rs2515400048 | 20:30,370,094 | A/G | — | uncertain significance |
| rs201467940 | 20:30,370,123 | C/T | — | uncertain significance |
| rs764950702 | 20:30,370,132 | C/T | — | uncertain significance |
| rs766700201 | 20:30,371,557 | C/A | — | uncertain significance |
| rs770633805 | 20:30,371,602 | A/G | — | likely benign |
| rs148051312 | 20:30,371,628 | A/G | — | benign |
| rs745643344 | 20:30,371,701 | A/G | — | uncertain significance |
| rs186886546 | 20:30,373,844 | T/C | intron variant | — |
| rs2515420916 | 20:30,380,547 | G/A | — | uncertain significance |
| rs760795199 | 20:30,380,559 | C/G | — | uncertain significance |
| rs746729105 | 20:30,380,595 | T/C | — | likely benign |
| rs780605957 | 20:30,380,611 | G/A | — | uncertain significance |
| rs61754553 | 20:30,381,660 | G/A | — | likely benign |
| rs531472784 | 20:30,381,664 | C/T | — | uncertain significance |
| rs150674434 | 20:30,381,670 | T/C | — | uncertain significance |
| rs2515424212 | 20:30,381,750 | C/T | — | uncertain significance |
| rs1062794 | 20:30,381,758 | G/A | synonymous variant | — |
| rs762675916 | 20:30,381,781 | G/A | — | uncertain significance |
| rs1237621613 | 20:30,382,284 | A/C | — | uncertain significance |
| rs2062145117 | 20:30,385,214 | A/G | — | uncertain significance |
| rs2515431958 | 20:30,385,282 | C/T | — | uncertain significance |
| rs2515433897 | 20:30,386,269 | G/C | — | uncertain significance |
| rs768387250 | 20:30,386,300 | G/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.