TRDN

triadin

Summary

This gene encodes an integral membrane protein found in skeletal and cardiac muscle. The encoded protein plays a role in skeletal muscle excitation-contraction coupling as part of the calcium release complex and is required for normal skeletal muscle strength. This protein indirectly links triads and microtubules in skeletal muscle. Mutations in this gene are associated with cardiac arrythmia syndrome and some variants in this gene may be associated with sudden cardiac death. [provided by RefSeq, May 2022]

Known Variants1,008 total

rsidPosition (GRCh37)AllelesClassClinVar
rs770493166:123,539,526G/A—benign
rs3615096:123,539,609C/T—benign
rs735431276:123,539,624A/T—likely benign
rs3615086:123,539,684T/C—benign
rs12596:123,539,685T/C—benign
rs3756701656:123,539,727A/C—likely benign
rs3696484626:123,539,731G/A—conflicting classifications of pathogenicity
rs12447474046:123,539,747T/C—likely benign
rs12640485576:123,539,748A/G—uncertain significance
rs3734390446:123,539,749C/A—conflicting classifications of pathogenicity
rs7697414266:123,539,751G/A—uncertain significance
rs25348359756:123,539,753C/A—uncertain significance
rs7774972756:123,539,754C/T—uncertain significance
rs17750266066:123,539,756T/C—uncertain significance
rs2010419816:123,539,757G/A—uncertain significance
rs14146892306:123,539,760G/A—uncertain significance
rs7705746246:123,539,767T/C—likely benign
rs21144921946:123,539,769C/T—uncertain significance
rs21144922006:123,539,771G/A—uncertain significance
rs7744496616:123,539,772G/C—conflicting classifications of pathogenicity
rs7756984436:123,539,776A/G—likely benign
rs25348360786:123,539,782T/G—uncertain significance
rs10108943236:123,539,786C/T—uncertain significance
rs17750274666:123,539,790A/G—uncertain significance
rs7687485306:123,539,793T/C—conflicting classifications of pathogenicity
rs5364871706:123,539,798C/T—uncertain significance
rs7618888586:123,539,801G/A—uncertain significance
rs17750279696:123,539,802G/A—uncertain significance
rs13111366146:123,539,803G/A—likely benign
rs7633759036:123,539,804C/T—uncertain significance
rs3734084986:123,539,805G/A—conflicting classifications of pathogenicity
rs12679206656:123,539,806G/T—uncertain significance
rs8766580326:123,539,810G/T—uncertain significance
rs25348361796:123,539,813G/A—uncertain significance
rs7512786956:123,539,814G/A—uncertain significance
rs25348361866:123,539,815A/T—likely benign
rs7808921676:123,539,826A/T—uncertain significance
rs7522488256:123,539,827C/A—uncertain significance
rs13908305786:123,539,828T/C—uncertain significance
rs25348362666:123,539,842A/G—likely benign
rs3773681776:123,539,843T/C—conflicting classifications of pathogenicity
rs7777799166:123,539,844T/C—uncertain significance
rs7491181636:123,539,845G/A—likely benign
rs14426411496:123,539,846T/C—uncertain significance
rs25348362946:123,539,847A/C—uncertain significance
rs7707480066:123,539,849C/T—uncertain significance
rs2020408796:123,539,852T/A—uncertain significance
rs12080496786:123,539,862C/T—uncertain significance
rs7766287626:123,539,863A/G—likely benign
rs21144924276:123,539,864C/G—uncertain significance
rs11880013016:123,539,876C/T—uncertain significance
rs13203708256:123,539,890G/A—likely benign
rs7737996646:123,539,891G/A—likely benign
rs25348365526:123,539,897A/G—likely benign
rs7633190036:123,539,898G/T—likely benign
rs77542056:123,539,904C/T—benign
rs7634764756:123,542,614A/G—likely benign
rs5438997496:123,542,616C/T—benign
rs7787222806:123,542,623T/C—likely benign
rs7581279756:123,542,630A/G—uncertain significance
rs12955306776:123,542,631C/T—uncertain significance
rs12888750416:123,542,645G/A—likely benign
rs17751469276:123,542,652A/C—uncertain significance
rs17751471176:123,542,655T/C—uncertain significance
rs7498498516:123,542,672T/A—likely benign
rs12444864236:123,542,673G/T—uncertain significance
rs7715628176:123,542,674G/A—likely benign
rs7749148416:123,542,676T/C—likely benign
rs1929396296:123,544,960T/C—likely benign
rs21145053236:123,545,218T/C—likely benign
rs21145053466:123,545,221A/G—likely benign
rs21145053506:123,545,223A/G—likely benign
rs12252103106:123,545,229C/A—likely benign
rs21145053626:123,545,232A/C—uncertain significance
rs21145053726:123,545,238C/T—uncertain significance
rs21145053846:123,545,241T/G—uncertain significance
rs7582159266:123,545,245T/C—likely benign
rs7796645106:123,545,250T/G—uncertain significance
rs8788548166:123,545,255G/T—uncertain significance
rs7484501676:123,545,256C/T—uncertain significance
rs11847613166:123,545,259G/T—uncertain significance
rs7562576446:123,545,262C/T—uncertain significance
rs3746355166:123,545,263A/G—likely benign
rs25348546636:123,545,266T/A—uncertain significance
rs25348546736:123,545,268C/A—uncertain significance
rs12197464796:123,545,272A/G—likely benign
rs9344862916:123,545,279A/G—uncertain significance
rs3687521396:123,545,282G/C—uncertain significance
rs25348547646:123,545,287G/A—likely benign
rs94907056:123,545,372C/T—benign
rs94907066:123,545,501G/C—benign
rs794880306:123,573,344A/G—likely benign
rs17764046786:123,573,543C/G—uncertain significance
rs1112767856:123,573,548C/T—likely benign
rs7540466966:123,573,549G/T—uncertain significance
rs7790914796:123,573,550T/C—likely benign
rs8999405386:123,573,552C/A—uncertain significance
rs25335043766:123,573,556C/G—uncertain significance
rs13031660286:123,573,561T/C—likely benign
rs10287031146:123,573,565C/T—conflicting classifications of pathogenicity

Showing 100 of 1,008 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.