TRIM54

tripartite motif containing 54

Summary

The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Known Variants36 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7544263492:27,505,609A/Guncertain significance
rs1426721682:27,505,680C/Tbenign
rs1384333232:27,505,755C/Tlikely benign
rs339949282:27,505,758C/Tbenign
rs1915390412:27,506,652G/A
rs1395373022:27,521,167A/Gintron variant
rs7748688042:27,521,532G/Auncertain significance
rs11691044212:27,521,567G/Auncertain significance
rs16789396722:27,521,578T/Guncertain significance
rs1464489952:27,522,165G/Tuncertain significance
rs11571656552:27,522,175A/Guncertain significance
rs1472806172:27,522,267A/Guncertain significance
rs13007265762:27,522,505G/Tuncertain significance
rs621307122:27,523,089G/Aintron variant
rs1423461382:27,527,292A/Tdownstream gene variant
rs353614212:27,527,850G/Abenign
rs7594899182:27,527,872C/Tuncertain significance
rs1497510512:27,527,875G/Auncertain significance
rs1391284422:27,527,897T/Guncertain significance
rs3773491742:27,528,446T/Guncertain significance
rs3685765922:27,528,551C/Tuncertain significance
rs7527602192:27,528,576G/Auncertain significance
rs1405343712:27,528,578G/Auncertain significance
rs7535976132:27,528,584G/Auncertain significance
rs2008685762:27,528,593C/Auncertain significance
rs1463481662:27,528,595T/Clikely benign
rs1493772172:27,528,600A/Guncertain significance
rs46659632:27,528,692T/Cbenign
rs2017073912:27,529,106C/Guncertain significance
rs1508050982:27,529,113G/Auncertain significance
rs1429227342:27,529,154G/Cuncertain significance
rs13374926722:27,529,323G/Auncertain significance
rs7726193182:27,529,326G/Auncertain significance
rs7613763992:27,529,357A/Guncertain significance
rs3768779902:27,529,367G/Cuncertain significance
rs7791779242:27,529,396C/Tlikely benign

Gene information from NCBI Gene. Variant classifications from ClinVar.