TRPC3
transient receptor potential cation channel subfamily C member 3
Summary
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Known Variants147 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs67775544 | 4:122,796,917 | G/A | regulatory region variant | — |
| rs72680779 | 4:122,797,263 | C/A | — | — |
| rs35495505 | 4:122,798,413 | T/C | regulatory region variant | — |
| rs199588234 | 4:122,800,913 | G/A | — | uncertain significance |
| rs145948370 | 4:122,800,922 | T/G | — | benign |
| rs200028855 | 4:122,800,956 | C/T | — | uncertain significance |
| rs765477300 | 4:122,800,966 | T/A | — | uncertain significance |
| rs142202711 | 4:122,800,971 | T/C | — | benign |
| rs2476713219 | 4:122,800,973 | T/C | — | uncertain significance |
| rs200301137 | 4:122,800,977 | C/T | — | uncertain significance |
| rs41278087 | 4:122,800,987 | C/T | — | benign |
| rs1553936310 | 4:122,803,512 | C/A | — | uncertain significance |
| rs1727973855 | 4:122,803,555 | A/G | — | likely benign |
| rs76977211 | 4:122,818,999 | C/T | intron variant | — |
| rs199888777 | 4:122,820,749 | C/T | — | likely benign |
| rs201207950 | 4:122,820,750 | G/A | — | likely benign |
| rs576172174 | 4:122,820,769 | G/T | — | uncertain significance |
| rs138232580 | 4:122,820,775 | G/A | — | uncertain significance |
| rs947275366 | 4:122,820,833 | C/T | — | likely benign |
| rs139940353 | 4:122,820,845 | G/A | — | likely benign |
| rs777360921 | 4:122,820,846 | T/G | — | uncertain significance |
| rs201660405 | 4:122,820,864 | C/T | — | likely benign |
| rs199536092 | 4:122,823,997 | C/T | — | likely benign |
| rs199601745 | 4:122,823,998 | G/A | — | likely benign |
| rs377662018 | 4:122,824,011 | G/A | — | uncertain significance |
| rs200465648 | 4:122,824,023 | C/T | — | uncertain significance |
| rs35312610 | 4:122,824,032 | A/G | — | uncertain significance |
| rs145796726 | 4:122,824,040 | A/G | — | likely benign |
| rs11732666 | 4:122,824,052 | C/T | — | benign |
| rs2476787647 | 4:122,824,063 | T/G | — | likely benign |
| rs1293654067 | 4:122,824,068 | T/C | — | uncertain significance |
| rs201449154 | 4:122,824,086 | C/T | — | uncertain significance |
| rs145430158 | 4:122,824,093 | T/A | — | uncertain significance |
| rs2476787838 | 4:122,824,094 | G/T | — | uncertain significance |
| rs147677309 | 4:122,824,106 | T/C | — | likely benign |
| rs1273666621 | 4:122,824,148 | T/G | — | uncertain significance |
| rs199928018 | 4:122,824,160 | A/G | — | likely benign |
| rs142339351 | 4:122,824,185 | C/T | missense variant | pathogenic |
| rs200628918 | 4:122,824,186 | G/A | — | uncertain significance |
| rs183145225 | 4:122,825,457 | T/C | — | benign |
| rs200415583 | 4:122,825,469 | C/T | — | likely benign |
| rs2476791516 | 4:122,825,514 | A/G | — | uncertain significance |
| rs752796351 | 4:122,825,547 | T/C | — | uncertain significance |
| rs1578617419 | 4:122,825,555 | T/C | — | likely benign |
| rs146271874 | 4:122,825,566 | C/T | — | uncertain significance |
| rs148274998 | 4:122,825,567 | G/A | — | likely benign |
| rs1297339645 | 4:122,825,601 | T/C | — | uncertain significance |
| rs140365543 | 4:122,825,603 | G/T | — | likely benign |
| rs112487014 | 4:122,825,612 | G/A | — | likely benign |
| rs769488090 | 4:122,825,617 | T/A | — | uncertain significance |
| rs2476792067 | 4:122,825,620 | C/T | — | uncertain significance |
| rs200042035 | 4:122,825,692 | C/G | — | likely benign |
| rs777376339 | 4:122,828,490 | G/T | — | uncertain significance |
| rs2476798310 | 4:122,828,497 | G/A | — | uncertain significance |
| rs2476798399 | 4:122,828,517 | A/C | — | uncertain significance |
| rs2476798624 | 4:122,828,548 | A/G | — | uncertain significance |
| rs891551044 | 4:122,828,621 | C/A | — | uncertain significance |
| rs200357045 | 4:122,828,630 | T/C | — | uncertain significance |
| rs750951273 | 4:122,828,666 | T/C | — | uncertain significance |
| rs1728930237 | 4:122,828,717 | C/T | — | uncertain significance |
| rs13127488 | 4:122,830,800 | A/G | intron variant | — |
| rs200366233 | 4:122,831,323 | T/C | — | uncertain significance |
| rs201026202 | 4:122,831,330 | C/G | — | uncertain significance |
| rs199633821 | 4:122,831,369 | C/T | — | uncertain significance |
| rs556308930 | 4:122,831,382 | A/G | — | likely benign |
| rs911390534 | 4:122,831,385 | C/G | — | uncertain significance |
| rs768500830 | 4:122,831,386 | T/A | — | uncertain significance |
| rs34507256 | 4:122,831,394 | C/T | — | likely benign |
| rs201887788 | 4:122,831,397 | C/T | — | benign |
| rs2476806062 | 4:122,831,447 | T/G | — | uncertain significance |
| rs1729037227 | 4:122,831,528 | C/T | — | uncertain significance |
| rs145740222 | 4:122,833,014 | T/G | — | likely benign |
| rs2476809947 | 4:122,833,028 | T/A | — | uncertain significance |
| rs747487340 | 4:122,833,204 | A/G | — | likely benign |
| rs2476811739 | 4:122,833,243 | C/T | — | likely benign |
| rs201276336 | 4:122,833,268 | A/G | — | likely benign |
| rs199650762 | 4:122,835,946 | G/A | — | uncertain significance |
| rs183645103 | 4:122,835,948 | G/A | — | uncertain significance |
| rs188254399 | 4:122,835,950 | G/A | — | likely benign |
| rs150143801 | 4:122,835,964 | T/A | — | uncertain significance |
| rs1243531035 | 4:122,835,971 | G/A | — | likely benign |
| rs34119323 | 4:122,835,980 | G/A | — | benign |
| rs150886370 | 4:122,835,991 | C/T | — | uncertain significance |
| rs765059359 | 4:122,835,992 | G/A | — | likely benign |
| rs199527931 | 4:122,836,008 | C/T | — | uncertain significance |
| rs140772812 | 4:122,836,062 | G/A | — | uncertain significance |
| rs376302115 | 4:122,836,073 | C/T | — | likely benign |
| rs201332366 | 4:122,836,118 | T/A | — | likely benign |
| rs144632591 | 4:122,846,193 | T/C | — | uncertain significance |
| rs145694364 | 4:122,846,208 | G/A | — | uncertain significance |
| rs774747811 | 4:122,846,210 | C/T | — | uncertain significance |
| rs2476893448 | 4:122,846,227 | C/T | — | likely benign |
| rs148910203 | 4:122,846,297 | C/T | — | uncertain significance |
| rs1403632056 | 4:122,846,298 | G/A | — | uncertain significance |
| rs2476894691 | 4:122,846,347 | C/A | — | uncertain significance |
| rs1729660334 | 4:122,846,354 | T/C | — | uncertain significance |
| rs201632499 | 4:122,853,407 | G/C | — | likely benign |
| rs2149142103 | 4:122,853,464 | C/T | — | uncertain significance |
| rs756858799 | 4:122,853,493 | G/T | — | uncertain significance |
| rs1250056098 | 4:122,853,500 | C/T | — | uncertain significance |
Showing 100 of 147 variants. Use the SNP search for the full list.
Gene information from NCBI Gene. Variant classifications from ClinVar.