TRPC4AP

transient receptor potential cation channel subfamily C member 4 associated protein

Summary

Enables phosphatase binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Located in cytosol. Part of Cul4A-RING E3 ubiquitin ligase complex. Is active in Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants56 total

rsidPosition (GRCh37)AllelesClassClinVar
rs20134028120:33,591,005C/Tuncertain significance
rs135980086520:33,591,074T/Guncertain significance
rs75207520:33,591,591C/Adownstream gene variant
rs77528031120:33,592,316T/Cuncertain significance
rs75556241320:33,592,335T/Cuncertain significance
rs74734670220:33,592,349C/Tuncertain significance
rs7996510220:33,593,847G/Adownstream gene variant
rs75505250020:33,594,265G/Cuncertain significance
rs13997550920:33,594,301C/Tlikely benign
rs251927793020:33,594,347C/Guncertain significance
rs148242305320:33,596,527C/Guncertain significance
rs18430648820:33,597,720A/Tintron variant
rs37667919420:33,597,994C/Tuncertain significance
rs188511720:33,600,740C/Tintron variant
rs608765920:33,606,383C/G
rs14017797120:33,606,407G/T
rs36951703120:33,608,946G/Aregulatory region variant
rs75259892920:33,609,007G/Auncertain significance
rs208288165620:33,609,062A/Cuncertain significance
rs57236748720:33,609,063T/Auncertain significance
rs18255339520:33,609,075A/Guncertain significance
rs14751680520:33,609,076T/Cuncertain significance
rs20103722920:33,609,105G/Auncertain significance
rs251517291420:33,609,152A/Cuncertain significance
rs19281029620:33,610,106G/Aintron variant
rs20199508220:33,623,039G/Auncertain significance
rs208351450520:33,632,311G/Cuncertain significance
rs251527220320:33,632,337A/Guncertain significance
rs76117897920:33,632,379G/Auncertain significance
rs208351730720:33,632,430A/Guncertain significance
rs74701865920:33,632,445G/Cuncertain significance
rs130675214320:33,637,774C/Guncertain significance
rs14081791920:33,645,338T/Guncertain significance
rs608766720:33,651,887A/Gintron variant
rs612081920:33,653,038T/Cintron variant
rs7537726620:33,656,783A/C
rs77440355620:33,657,120A/Cuncertain significance
rs75908032620:33,657,163C/Guncertain significance
rs614153020:33,663,147T/A
rs75526141820:33,665,911G/Auncertain significance
rs13980049920:33,665,969C/Tlikely benign
rs135301218820:33,665,973G/Auncertain significance
rs218084720:33,667,763G/A
rs611956920:33,672,371G/Aintron variant
rs2853605920:33,674,328A/C
rs95305574520:33,680,418T/Cuncertain significance
rs126364877220:33,680,424G/Tuncertain significance
rs77977758520:33,680,427C/Auncertain significance
rs74897377920:33,680,428G/Auncertain significance
rs77153180420:33,680,461G/Auncertain significance
rs76416508020:33,680,517G/Auncertain significance
rs102511504020:33,680,538C/Guncertain significance
rs75357665320:33,680,545G/Cuncertain significance
rs74773801320:33,680,550G/Auncertain significance
rs77146386520:33,680,556G/Cuncertain significance
rs76896174620:33,680,580G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.