TRPM4

transient receptor potential cation channel subfamily M member 4

Summary

The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016]

Known Variants1,361 total

rsidPosition (GRCh37)AllelesClassClinVar
rs11353755919:49,660,862C/T—likely benign
rs376066219:49,660,889G/A—benign
rs11208549519:49,661,017G/T—conflicting classifications of pathogenicity
rs376066319:49,661,112A/G—benign
rs96906404119:49,661,124A/G—uncertain significance
rs204154178119:49,661,125T/C—uncertain significance
rs251402299519:49,661,126G/C—uncertain significance
rs53199771519:49,661,129G/T—likely benign
rs160037822919:49,661,131T/C—uncertain significance
rs128022789219:49,661,133C/T—conflicting classifications of pathogenicity
rs131865687919:49,661,134C/G—uncertain significance
rs140304367619:49,661,135G/A—likely benign
rs99957267319:49,661,136G/A—uncertain significance
rs204154255219:49,661,137A/C—uncertain significance
rs212272318519:49,661,141G/C—uncertain significance
rs26760714219:49,661,142G/Amissense variantpathogenic
rs105752281119:49,661,146A/T—uncertain significance
rs204154304319:49,661,147G/A—uncertain significance
rs160037835219:49,661,152G/A—uncertain significance
rs76790087919:49,661,153C/G—conflicting classifications of pathogenicity
rs96052296019:49,661,154G/A—likely benign
rs75578385519:49,661,157G/A—likely benign
rs125658105719:49,661,162A/G—likely benign
rs117198866019:49,661,435G/T—likely benign
rs212272522619:49,661,436T/C—likely benign
rs36931203119:49,661,439C/T—likely benign
rs74955196719:49,661,443C/A—likely benign
rs77462222619:49,661,449A/G—uncertain significance
rs89345646919:49,661,454G/A—uncertain significance
rs139634894919:49,661,455A/G—uncertain significance
rs76797267319:49,661,462A/G—uncertain significance
rs100927746719:49,661,469C/A—uncertain significance
rs77606682819:49,661,472G/C—uncertain significance
rs251402458019:49,661,473A/G—uncertain significance
rs251402459119:49,661,475G/T—uncertain significance
rs86462264319:49,661,482T/A—uncertain significance
rs139991651519:49,661,486C/T—uncertain significance
rs160037960719:49,661,489C/T—uncertain significance
rs76088744319:49,661,493C/G—uncertain significance
rs37294248819:49,661,505C/T—likely benign
rs136898295519:49,661,507C/T—uncertain significance
rs204155507019:49,661,509G/C—uncertain significance
rs251402472119:49,661,510A/G—uncertain significance
rs20086866619:49,661,513C/T—uncertain significance
rs251402475519:49,661,519G/A—uncertain significance
rs97925739819:49,661,521G/C—uncertain significance
rs14231768419:49,661,527C/A—benign
rs37743194619:49,661,528G/A—conflicting classifications of pathogenicity
rs75790917219:49,661,529C/T—likely benign
rs75468598119:49,661,533T/C—likely benign
rs1188256319:49,661,547G/A—benign
rs376066419:49,661,582C/T—benign
rs376066519:49,661,678G/C—benign
rs725249319:49,669,188T/C—benign
rs75141916219:49,669,278C/G—likely benign
rs15030099319:49,669,280C/T—benign
rs78111717019:49,669,281C/T—likely benign
rs18413206919:49,669,285C/T—likely benign
rs74611280819:49,669,288G/A—likely benign
rs90941504519:49,669,291C/T—likely benign
rs96396551419:49,669,294C/A—likely benign
rs121665149019:49,669,299G/A—uncertain significance
rs196716033719:49,669,301G/A—likely benign
rs76523009919:49,669,304C/T—likely benign
rs78023160219:49,669,305T/C—likely benign
rs156845656019:49,669,306T/G—uncertain significance
rs86592046619:49,669,320C/T—uncertain significance
rs120294989219:49,669,321G/A—uncertain significance
rs76927233819:49,669,322C/T—likely benign
rs77713142219:49,669,324C/T—uncertain significance
rs102874620219:49,669,326C/T—uncertain significance
rs76211151519:49,669,329A/G—uncertain significance
rs77016956619:49,669,330C/T—uncertain significance
rs140103453019:49,669,331C/T—likely benign
rs11214915519:49,669,332G/A—uncertain significance
rs160040045219:49,669,336A/G—uncertain significance
rs144843287219:49,669,340C/T—likely benign
rs75113489519:49,669,341G/T—uncertain significance
rs75938368319:49,669,349C/T—likely benign
rs93298769019:49,669,350A/C—uncertain significance
rs76749510019:49,669,360C/G—uncertain significance
rs75269513919:49,669,364C/T—likely benign
rs251404666319:49,669,365G/A—uncertain significance
rs37680892319:49,669,370A/G—likely benign
rs37119288619:49,669,373C/T—likely benign
rs75059005219:49,669,374G/C—uncertain significance
rs196716552019:49,669,377G/A—uncertain significance
rs196716573419:49,669,383G/C—uncertain significance
rs77999360919:49,669,386T/A—uncertain significance
rs74704833519:49,669,389G/A—uncertain significance
rs76863513019:49,669,394C/T—likely benign
rs78163104719:49,669,395G/A—uncertain significance
rs131719195219:49,669,399C/T—uncertain significance
rs57800884719:49,669,403C/T—likely benign
rs155575088319:49,669,411A/G—uncertain significance
rs77387898519:49,669,416C/T—uncertain significance
rs75902729319:49,669,420C/T—uncertain significance
rs76715583219:49,669,421C/T—likely benign
rs77552646319:49,669,422G/A—conflicting classifications of pathogenicity
rs76396995619:49,669,430C/T—likely benign

Showing 100 of 1,361 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.