TRRAP

transformation/transcription domain associated protein

Summary

This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Known Variants1,591 total

rsidPosition (GRCh37)AllelesClassClinVar
rs7464418047:98,475,823G/A——
rs64657267:98,478,680A/G—benign
rs1467829657:98,478,779G/A—likely benign
rs17954113447:98,478,801A/G—uncertain significance
rs13243298907:98,478,802C/T—likely benign
rs24846073367:98,478,805T/C—uncertain significance
rs24846073597:98,478,811A/C—uncertain significance
rs15544029937:98,478,822T/C—likely benign
rs14119336207:98,478,825A/C—uncertain significance
rs21162223507:98,478,832A/G—uncertain significance
rs21162224157:98,478,852G/C—uncertain significance
rs24846075287:98,478,854T/C—likely benign
rs2009164027:98,479,589C/T—likely benign
rs5635973947:98,479,590G/A—likely benign
rs15544031867:98,479,594A/G—likely benign
rs17954616477:98,479,601A/G—uncertain significance
rs24846120177:98,479,639A/T—uncertain significance
rs24846120347:98,479,650A/G—uncertain significance
rs1166455097:98,479,655C/T—benign
rs3716726177:98,479,656A/G—likely benign
rs69638937:98,479,707G/A—benign
rs14056786087:98,487,941T/C—likely benign
rs7819249297:98,487,953A/C—likely benign
rs7821394407:98,487,965C/T—likely benign
rs7821251307:98,487,984T/C—likely benign
rs1437082337:98,487,991C/T—likely benign
rs24846487497:98,488,005C/A—likely benign
rs3759848967:98,488,007C/T—uncertain significance
rs24846487757:98,488,010G/A—uncertain significance
rs24846487847:98,488,012T/C—uncertain significance
rs24846489237:98,488,055A/G—uncertain significance
rs24846489377:98,488,059A/G—likely benign
rs24846565077:98,490,036T/A—likely benign
rs5622780747:98,490,041T/C—likely benign
rs7824454487:98,490,054G/A—uncertain significance
rs12928890397:98,490,079T/C—likely benign
rs24846566257:98,490,083A/G—likely benign
rs7822026467:98,490,100T/C—likely benign
rs24846568027:98,490,127G/T—uncertain significance
rs7825670007:98,490,131G/A—uncertain significance
rs7820384967:98,490,136G/A—likely benign
rs8689883277:98,490,149G/C—uncertain significance
rs22491697:98,491,261T/C—benign
rs7823617747:98,491,401C/G—likely benign
rs15544053017:98,491,402A/T—likely benign
rs788712437:98,491,411T/C—likely benign
rs3690763747:98,491,418T/C—uncertain significance
rs7827216927:98,491,421A/G—uncertain significance
rs1481012677:98,491,422C/T—uncertain significance
rs2008035597:98,491,442C/A—uncertain significance
rs24846612547:98,491,455G/C—uncertain significance
rs3755244137:98,491,456A/G—likely benign
rs7821844597:98,491,491C/T—uncertain significance
rs1403093927:98,491,492G/A—likely benign
rs10273512997:98,492,363A/G—uncertain significance
rs7827135977:98,493,367A/G—likely benign
rs7818915247:98,493,371T/G—uncertain significance
rs15544056327:98,493,383T/G—likely benign
rs13349499667:98,493,389T/A—likely benign
rs7821622627:98,493,390C/A—uncertain significance
rs15544056357:98,493,391A/G—uncertain significance
rs7825632627:98,493,422C/T—likely benign
rs7820281087:98,493,449T/G—uncertain significance
rs78109337:98,495,304G/T—benign
rs2001572117:98,495,367C/T—likely benign
rs12981757207:98,495,368G/A—uncertain significance
rs5478245727:98,495,387A/G—likely benign
rs7827542497:98,495,388G/A—uncertain significance
rs15544060037:98,495,395C/T—uncertain significance
rs1503417497:98,495,396C/A—likely benign
rs17962858207:98,495,406G/A—uncertain significance
rs557026497:98,495,408G/C—benign
rs24846744497:98,495,430A/T—uncertain significance
rs3725246467:98,495,461C/T—conflicting classifications of pathogenicity
rs7824548277:98,495,462G/A—likely benign
rs5731343937:98,495,466C/T—uncertain significance
rs2014528377:98,495,467G/A—likely benign
rs1437115287:98,495,471G/A—likely benign
rs7825969737:98,495,475A/G—uncertain significance
rs7822203327:98,495,481A/G—conflicting classifications of pathogenicity
rs17775234437:98,495,484C/G—uncertain significance
rs7819286617:98,495,499T/A—likely benign
rs1915356147:98,495,500C/T—benign
rs5358383247:98,495,501G/A—likely benign
rs1133399487:98,497,042C/T—conflicting classifications of pathogenicity
rs7818467897:98,497,051A/G—uncertain significance
rs7828067857:98,497,059G/A—likely benign
rs8689655297:98,497,071T/G—likely benign
rs17963739967:98,497,116G/A—uncertain significance
rs24846796677:98,497,125A/G—uncertain significance
rs24846796727:98,497,127G/A—uncertain significance
rs24846797257:98,497,136T/C—likely benign
rs102798137:98,497,206C/G—benign
rs15544063277:98,497,286G/A—likely benign
rs24846804967:98,497,314A/G—uncertain significance
rs15544063307:98,497,319C/T—likely benign
rs15544063367:98,497,326G/A—uncertain significance
rs2004229397:98,497,346C/T—benign
rs24846806237:98,497,356A/G—uncertain significance
rs15544063417:98,497,360C/G—uncertain significance

Showing 100 of 1,591 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.