TSLP
thymic stromal lymphopoietin
Summary
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. In addition, the shorter (predominant) isoform is an antimicrobial protein, displaying antibacterial and antifungal activity against B. cereus, E. coli, E. faecalis, S. mitis, S. epidermidis, and C. albicans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]
Known Variants21 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs3806932 | 5:110,405,675 | A/G | regulatory region variant | — |
| rs3806933 | 5:110,406,742 | C/T | upstream gene variant | — |
| rs2289276 | 5:110,407,507 | C/T | 5 prime UTR variant | — |
| rs777564341 | 5:110,407,623 | T/A | — | uncertain significance |
| rs1179899313 | 5:110,407,658 | G/C | — | uncertain significance |
| rs753501114 | 5:110,407,691 | G/A | — | uncertain significance |
| rs1435982334 | 5:110,407,696 | T/G | — | uncertain significance |
| rs1898671 | 5:110,408,002 | C/T | downstream gene variant | — |
| rs10062929 | 5:110,408,179 | C/A | downstream gene variant | — |
| rs199671638 | 5:110,408,595 | A/G | — | uncertain significance |
| rs2531731340 | 5:110,408,617 | C/G | — | uncertain significance |
| rs11466741 | 5:110,408,705 | C/G | — | — |
| rs11466742 | 5:110,408,743 | C/G | regulatory region variant | — |
| rs2289278 | 5:110,409,148 | C/G | regulatory region variant | — |
| rs1267224802 | 5:110,409,267 | C/G | — | uncertain significance |
| rs140730628 | 5:110,411,702 | G/C | — | uncertain significance |
| rs372152752 | 5:110,411,710 | C/A | — | uncertain significance |
| rs11466749 | 5:110,412,585 | A/G | downstream gene variant | — |
| rs11466750 | 5:110,412,894 | G/A | downstream gene variant | — |
| rs10073816 | 5:110,413,489 | G/T | — | — |
| rs11466754 | 5:110,413,731 | C/G | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.