TST
thiosulfate sulfurtransferase
Summary
This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Known Variants26 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs772331969 | 22:37,407,118 | G/A | — | uncertain significance |
| rs761288130 | 22:37,407,151 | C/T | — | uncertain significance |
| rs530144727 | 22:37,407,169 | C/T | — | uncertain significance |
| rs144544206 | 22:37,407,193 | C/T | — | uncertain significance |
| rs143561353 | 22:37,407,222 | G/A | — | uncertain significance |
| rs140912272 | 22:37,407,240 | G/A | — | uncertain significance |
| rs2518065634 | 22:37,407,255 | T/G | — | uncertain significance |
| rs374228043 | 22:37,407,273 | C/T | — | uncertain significance |
| rs375907649 | 22:37,407,331 | T/G | — | uncertain significance |
| rs182959969 | 22:37,408,175 | G/A | — | — |
| rs940081461 | 22:37,414,170 | G/A | — | likely benign |
| rs758141663 | 22:37,414,190 | G/A | — | uncertain significance |
| rs777456318 | 22:37,414,196 | G/T | — | uncertain significance |
| rs138956044 | 22:37,414,217 | C/T | — | uncertain significance |
| rs201928797 | 22:37,414,283 | G/A | — | uncertain significance |
| rs759704785 | 22:37,414,320 | C/A | — | uncertain significance |
| rs61743068 | 22:37,414,321 | G/C | — | likely benign |
| rs140074808 | 22:37,414,326 | G/A | — | uncertain significance |
| rs1297950891 | 22:37,414,376 | T/C | — | uncertain significance |
| rs145497510 | 22:37,414,385 | C/G | — | uncertain significance |
| rs147266371 | 22:37,414,404 | C/T | — | uncertain significance |
| rs781611380 | 22:37,414,543 | G/C | — | uncertain significance |
| rs761025400 | 22:37,414,617 | C/T | — | uncertain significance |
| rs760695375 | 22:37,414,622 | C/T | — | uncertain significance |
| rs1314470757 | 22:37,414,634 | T/C | — | uncertain significance |
| rs2518074277 | 22:37,414,682 | A/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.