TTLL8
tubulin tyrosine ligase like 8
Summary
Predicted to enable protein-glycine ligase activity, initiating. Predicted to be involved in several processes, including axoneme assembly; flagellated sperm motility; and protein polyglycylation. Predicted to act upstream of or within cilium assembly. Predicted to be located in cilium. Predicted to be active in axoneme; microtubule cytoskeleton; and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants4 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs7288137 | 22:50,458,020 | G/A | intron variant | — |
| rs76786083 | 22:50,472,838 | G/A | — | likely benign |
| rs56330886 | 22:50,493,427 | T/G | downstream gene variant | — |
| rs137917 | 22:50,494,531 | A/T | downstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.