UBD
ubiquitin like modifier D
Summary
This gene encodes a protein which contains two ubiquitin-like domains and appears to have similar function to ubiquitin. Through covalent attachment, the encoded protein targets other proteins for 26S proteasome degradation. This protein has been implicated to function in many cellular processes, including caspase-dependent apoptosis, formation of aggresomes, mitotic regulation, and dendritic cell maturation. Upregulation of this gene may promote inflammation in chronic kidney disease and has been observed in many cancer types. [provided by RefSeq, Aug 2017]
Known Variants8 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1047688718 | 6:29,523,693 | G/T | — | uncertain significance |
| rs544222490 | 6:29,523,710 | C/T | — | likely benign |
| rs758148791 | 6:29,523,925 | G/A | — | uncertain significance |
| rs1347053804 | 6:29,523,956 | C/T | — | uncertain significance |
| rs753894789 | 6:29,524,117 | C/T | — | likely benign |
| rs11970475 | 6:29,526,377 | G/A | downstream gene variant | — |
| rs413670 | 6:29,526,562 | G/C | — | — |
| rs199851908 | 6:29,527,467 | A/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.