UGT2A1
UDP glucuronosyltransferase family 2 member A1 complex locus
Summary
The protein encoded by this gene belongs to the UDP-glycosyltransferase family. Members of this protein family play a role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The encoded enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. Polymorphisms in this gene may be associated with the loss of taste and smell that is reported by some individuals during SARS-CoV-2 infection. [provided by RefSeq, Jan 2022]
Known Variants30 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs144056072 | 4:70,455,211 | G/T | — | uncertain significance |
| rs139303872 | 4:70,455,305 | G/A | — | likely benign |
| rs10017134 | 4:70,457,021 | T/C | intron variant | — |
| rs150848863 | 4:70,460,320 | C/T | — | likely benign |
| rs146749264 | 4:70,460,329 | T/A | — | benign |
| rs541627076 | 4:70,460,923 | G/A | — | likely benign |
| rs146912371 | 4:70,460,944 | C/A | — | likely benign |
| rs974321457 | 4:70,461,993 | G/A | — | uncertain significance |
| rs4148298 | 4:70,464,701 | A/G | intron variant | — |
| rs781112509 | 4:70,465,030 | A/C | — | likely benign |
| rs10028954 | 4:70,466,280 | T/C | intron variant | — |
| rs184330259 | 4:70,510,791 | A/T | — | — |
| rs771258078 | 4:70,512,677 | G/A | — | uncertain significance |
| rs149931914 | 4:70,512,719 | G/A | — | uncertain significance |
| rs111696697 | 4:70,512,787 | A/T | — | likely benign |
| rs530620535 | 4:70,512,788 | T/C | — | uncertain significance |
| rs2529552659 | 4:70,512,859 | C/T | — | likely benign |
| rs760550229 | 4:70,512,887 | A/C | — | uncertain significance |
| rs371530829 | 4:70,512,896 | C/T | — | uncertain significance |
| rs2529553163 | 4:70,512,937 | G/T | — | uncertain significance |
| rs759356275 | 4:70,513,014 | C/T | — | likely benign |
| rs138860923 | 4:70,513,109 | C/T | — | uncertain significance |
| rs746698012 | 4:70,513,122 | C/T | — | uncertain significance |
| rs145089093 | 4:70,513,163 | G/T | — | uncertain significance |
| rs781059827 | 4:70,513,196 | G/A | — | uncertain significance |
| rs113894762 | 4:70,513,199 | A/G | — | benign |
| rs749075207 | 4:70,513,220 | T/C | — | uncertain significance |
| rs978989074 | 4:70,513,241 | T/C | — | uncertain significance |
| rs141956545 | 4:70,513,281 | T/C | — | uncertain significance |
| rs1375743312 | 4:70,513,295 | A/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.