USO1
USO1 vesicle transport factor
Summary
The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Known Variants3 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs71607333 | 4:76,690,980 | T/G | intron variant | — |
| rs79609612 | 4:76,699,758 | A/G | intron variant | — |
| rs1723002439 | 4:76,727,702 | G/A | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.