VARS1

valyl-tRNA synthetase 1

Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]

Known Variants193 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs3130491	6:31,745,464	G/A	regulatory region variant	—
rs909267	6:31,746,548	T/C	downstream gene variant	—
rs1206964821	6:31,746,764	G/A	—	uncertain significance
rs1472868752	6:31,746,775	G/T	—	uncertain significance
rs2537582454	6:31,746,782	T/C	—	uncertain significance
rs375257266	6:31,746,806	G/A	—	uncertain significance
rs752273148	6:31,746,814	C/T	—	uncertain significance
rs757787598	6:31,746,815	G/A	—	uncertain significance
rs368075745	6:31,746,820	C/T	—	uncertain significance
rs181542871	6:31,746,821	G/A	—	benign
rs1812931789	6:31,746,824	G/A	—	pathogenic
rs766385187	6:31,746,847	C/T	—	uncertain significance
rs776596987	6:31,746,848	G/A	—	pathogenic
rs752223950	6:31,746,874	C/T	—	uncertain significance
rs141077941	6:31,746,875	G/A	—	likely benign
rs2537583576	6:31,746,879	A/C	—	likely benign
rs1437171498	6:31,746,891	C/T	—	likely benign
rs2537583742	6:31,746,895	T/C	—	uncertain significance
rs200588763	6:31,746,948	C/G	—	likely benign
rs61730576	6:31,747,011	G/A	—	likely benign
rs769749489	6:31,747,038	G/A	—	likely benign
rs761105119	6:31,747,053	C/T	—	likely benign
rs1368016403	6:31,747,210	C/G	—	uncertain significance
rs150145769	6:31,747,216	C/T	—	uncertain significance
rs761497924	6:31,747,231	T/C	—	uncertain significance
rs777127030	6:31,747,240	A/G	—	uncertain significance
rs149378938	6:31,747,247	G/A	missense variant	pathogenic
rs1226600950	6:31,747,256	G/T	—	likely benign
rs373279419	6:31,747,258	G/C	—	likely pathogenic
rs2537587634	6:31,747,266	T/C	—	likely benign
rs148853234	6:31,747,269	C/A	—	benign
rs760160304	6:31,747,284	G/A	—	likely benign
rs1006815876	6:31,747,385	C/A	—	uncertain significance
rs2151417852	6:31,747,407	G/A	—	likely pathogenic
rs1812998494	6:31,747,420	T/C	—	uncertain significance
rs1230283665	6:31,747,459	A/G	—	conflicting classifications of pathogenicity
rs777665186	6:31,747,470	G/A	—	conflicting classifications of pathogenicity
rs1562293093	6:31,747,481	C/T	—	pathogenic
rs2537589468	6:31,747,491	G/A	—	likely pathogenic
rs769369302	6:31,747,500	C/T	missense variant	pathogenic
rs5030798	6:31,747,510	C/T	—	benign
rs1171083155	6:31,747,511	G/A	—	likely benign
rs1470323684	6:31,747,536	C/T	—	uncertain significance
rs201902100	6:31,747,555	C/T	—	benign
rs765740144	6:31,747,558	G/A	—	likely pathogenic
rs781050521	6:31,747,828	C/T	—	uncertain significance
rs759494295	6:31,747,832	C/T	—	likely benign
rs1076827	6:31,747,833	G/A	—	benign
rs774097471	6:31,747,840	C/T	—	uncertain significance
rs750209360	6:31,747,860	T/C	—	uncertain significance
rs372518287	6:31,747,887	C/T	—	uncertain significance
rs571597169	6:31,747,894	G/A	—	uncertain significance
rs758873284	6:31,747,902	C/T	—	likely pathogenic
rs1401631657	6:31,748,228	G/A	—	uncertain significance
rs780044529	6:31,748,259	G/A	—	uncertain significance
rs2151419153	6:31,748,286	G/A	—	uncertain significance
rs150882285	6:31,748,303	C/T	missense variant	pathogenic
rs1336685414	6:31,748,318	C/T	—	likely pathogenic
rs764895082	6:31,748,319	G/A	—	likely pathogenic
rs1330959651	6:31,748,512	G/A	—	uncertain significance
rs370606971	6:31,748,521	C/T	—	uncertain significance
rs202052942	6:31,748,539	T/A	—	uncertain significance
rs144311815	6:31,748,544	G/T	—	uncertain significance
rs768271792	6:31,748,565	A/G	—	likely benign
rs766945110	6:31,748,676	T/G	—	uncertain significance
rs138415788	6:31,748,678	G/C	—	uncertain significance
rs1060499734	6:31,748,712	G/A	missense variant	pathogenic
rs1813108936	6:31,748,807	T/C	—	likely benign
rs1356142984	6:31,748,819	C/T	—	uncertain significance
rs707926	6:31,748,820	G/A	synonymous variant	benign
rs1182485353	6:31,748,848	G/C	—	uncertain significance
rs761810499	6:31,748,879	G/C	—	uncertain significance
rs368315640	6:31,748,896	T/C	—	uncertain significance
rs915652	6:31,749,142	G/C	—	—
rs915651	6:31,749,184	G/A	upstream gene variant	—
rs1287489465	6:31,749,254	G/A	—	uncertain significance
rs1813143878	6:31,749,296	G/C	—	uncertain significance
rs376864621	6:31,749,338	C/T	—	pathogenic
rs779600047	6:31,749,370	C/G	—	uncertain significance
rs1813160712	6:31,749,516	C/T	—	pathogenic
rs1813164650	6:31,749,556	T/G	—	uncertain significance
rs138353806	6:31,749,689	G/A	—	uncertain significance
rs746755292	6:31,749,698	C/T	—	uncertain significance
rs1294452351	6:31,749,699	G/A	—	uncertain significance
rs1813177306	6:31,749,704	C/G	—	uncertain significance
rs2537606444	6:31,749,713	T/C	—	uncertain significance
rs368988920	6:31,749,717	G/A	—	uncertain significance
rs764768184	6:31,749,728	T/A	—	uncertain significance
rs1394960891	6:31,749,875	G/T	—	uncertain significance
rs767330862	6:31,749,880	G/A	—	uncertain significance
rs781064928	6:31,749,916	C/T	—	uncertain significance
rs1813197994	6:31,749,936	C/G	—	uncertain significance
rs369903710	6:31,750,059	C/T	—	uncertain significance
rs765338623	6:31,750,069	T/C	—	uncertain significance
rs1438741334	6:31,750,093	G/A	—	uncertain significance
rs1394009242	6:31,750,101	G/A	—	uncertain significance
rs754688832	6:31,750,126	C/G	—	uncertain significance
rs747824231	6:31,750,138	C/G	—	pathogenic
rs116047950	6:31,750,139	G/A	—	likely benign
rs777386611	6:31,750,142	G/A	—	likely benign

Showing 100 of 193 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.