VEGFD
vascular endothelial growth factor D
Summary
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]
Known Variants6 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs146086561 | X:15,365,438 | C/T | missense variant | — |
| rs149425095 | X:15,373,382 | T/C | — | benign |
| rs745810706 | X:15,376,137 | G/A | — | likely benign |
| rs148025234 | X:15,376,284 | G/A | — | likely benign |
| rs12843566 | X:15,400,259 | A/T | — | — |
| rs753537678 | X:15,401,984 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.