VNN2
vanin 2
Summary
This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Known Variants45 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2483450229 | 6:133,065,450 | C/T | — | uncertain significance |
| rs1435120046 | 6:133,065,458 | T/G | — | uncertain significance |
| rs1379988313 | 6:133,065,459 | G/T | — | uncertain significance |
| rs1779597869 | 6:133,065,522 | C/T | — | uncertain significance |
| rs1443205046 | 6:133,065,525 | A/G | — | uncertain significance |
| rs763648969 | 6:133,065,537 | G/C | — | uncertain significance |
| rs141755989 | 6:133,065,614 | C/T | — | uncertain significance |
| rs145987032 | 6:133,066,098 | A/C | intron variant | — |
| rs34696126 | 6:133,068,992 | T/C | upstream gene variant | — |
| rs933145880 | 6:133,070,952 | G/T | — | uncertain significance |
| rs776803491 | 6:133,070,955 | C/T | — | likely benign |
| rs567139324 | 6:133,070,971 | A/C | — | uncertain significance |
| rs1311412062 | 6:133,072,295 | C/T | — | uncertain significance |
| rs34856068 | 6:133,072,306 | C/T | — | benign |
| rs141464795 | 6:133,072,319 | C/T | — | uncertain significance |
| rs373975592 | 6:133,072,337 | C/T | — | uncertain significance |
| rs748667023 | 6:133,072,366 | A/T | — | uncertain significance |
| rs1780064797 | 6:133,072,367 | T/C | — | uncertain significance |
| rs932178009 | 6:133,072,468 | C/A | — | uncertain significance |
| rs751202448 | 6:133,072,628 | T/G | — | uncertain significance |
| rs13204496 | 6:133,073,248 | A/T | upstream gene variant | — |
| rs33920182 | 6:133,073,705 | C/A | — | uncertain significance |
| rs139095644 | 6:133,073,797 | G/A | — | uncertain significance |
| rs34492437 | 6:133,073,811 | C/A | — | likely benign |
| rs184575638 | 6:133,074,010 | C/T | coding sequence variant | — |
| rs2300078 | 6:133,075,441 | A/C | — | — |
| rs35966392 | 6:133,076,118 | G/C | downstream gene variant | — |
| rs142626186 | 6:133,076,999 | C/T | missense variant | — |
| rs769921239 | 6:133,077,062 | A/G | — | uncertain significance |
| rs864622023 | 6:133,077,069 | G/T | — | uncertain significance |
| rs765105820 | 6:133,077,073 | C/T | — | uncertain significance |
| rs181383701 | 6:133,077,080 | T/C | — | uncertain significance |
| rs185267705 | 6:133,077,134 | C/T | — | uncertain significance |
| rs183643997 | 6:133,077,338 | T/A | downstream gene variant | — |
| rs147008540 | 6:133,078,633 | G/A | — | benign |
| rs764428784 | 6:133,078,678 | C/T | — | likely benign |
| rs34100251 | 6:133,078,747 | C/G | downstream gene variant | — |
| rs117133724 | 6:133,078,759 | C/T | downstream gene variant | — |
| rs201471643 | 6:133,078,832 | G/A | — | uncertain significance |
| rs752931970 | 6:133,078,855 | C/A | — | uncertain significance |
| rs146238193 | 6:133,078,866 | G/C | — | uncertain significance |
| rs139348170 | 6:133,078,886 | G/A | — | conflicting classifications of pathogenicity |
| rs746485389 | 6:133,078,956 | G/C | — | uncertain significance |
| rs33950336 | 6:133,078,973 | G/T | — | benign |
| rs1325904058 | 6:133,078,975 | T/C | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.