VPS18
VPS18 core subunit of CORVET and HOPS complexes
Summary
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]
Known Variants67 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1307464180 | 15:41,187,010 | C/T | — | uncertain significance |
| rs771604365 | 15:41,187,020 | G/T | — | uncertain significance |
| rs2542504717 | 15:41,188,161 | G/T | — | uncertain significance |
| rs2542504788 | 15:41,188,205 | C/T | — | uncertain significance |
| rs776596580 | 15:41,188,225 | G/C | — | uncertain significance |
| rs1367892021 | 15:41,191,107 | T/C | — | uncertain significance |
| rs749263460 | 15:41,191,169 | G/A | — | uncertain significance |
| rs757206323 | 15:41,191,174 | C/A | — | uncertain significance |
| rs745649330 | 15:41,191,179 | T/C | — | uncertain significance |
| rs747208120 | 15:41,191,384 | A/G | — | uncertain significance |
| rs761368383 | 15:41,191,386 | G/A | — | uncertain significance |
| rs781314701 | 15:41,191,393 | G/A | — | uncertain significance |
| rs887167374 | 15:41,191,459 | A/G | — | uncertain significance |
| rs763837404 | 15:41,191,470 | G/A | — | uncertain significance |
| rs764760605 | 15:41,191,480 | G/A | — | uncertain significance |
| rs755250424 | 15:41,191,506 | A/T | — | uncertain significance |
| rs1351057423 | 15:41,191,509 | G/A | — | uncertain significance |
| rs553162824 | 15:41,191,536 | C/G | — | uncertain significance |
| rs1339958105 | 15:41,191,564 | G/T | — | uncertain significance |
| rs750271741 | 15:41,191,573 | C/T | — | uncertain significance |
| rs1361385087 | 15:41,191,804 | G/A | — | uncertain significance |
| rs752138511 | 15:41,191,921 | C/T | — | uncertain significance |
| rs771044706 | 15:41,192,104 | T/C | — | uncertain significance |
| rs1892315465 | 15:41,192,157 | T/C | — | uncertain significance |
| rs1297039944 | 15:41,192,178 | C/T | — | uncertain significance |
| rs202222195 | 15:41,192,187 | G/T | — | uncertain significance |
| rs2542512164 | 15:41,192,197 | A/G | — | uncertain significance |
| rs376126131 | 15:41,192,235 | C/T | — | uncertain significance |
| rs373367742 | 15:41,192,287 | C/T | — | uncertain significance |
| rs369670077 | 15:41,192,298 | C/T | — | uncertain significance |
| rs770059646 | 15:41,192,299 | G/A | — | uncertain significance |
| rs2542512467 | 15:41,192,305 | C/T | — | uncertain significance |
| rs374798374 | 15:41,192,309 | T/A | — | uncertain significance |
| rs1892325697 | 15:41,192,446 | T/G | — | uncertain significance |
| rs771450559 | 15:41,192,470 | G/A | — | uncertain significance |
| rs761367729 | 15:41,192,507 | G/C | — | uncertain significance |
| rs766177353 | 15:41,192,520 | C/T | — | uncertain significance |
| rs79536497 | 15:41,192,540 | C/T | — | likely benign |
| rs772540233 | 15:41,192,580 | T/C | — | likely benign |
| rs148408369 | 15:41,192,613 | A/C | — | uncertain significance |
| rs1892331477 | 15:41,192,614 | A/G | — | uncertain significance |
| rs1275426124 | 15:41,192,767 | C/T | — | uncertain significance |
| rs377448468 | 15:41,192,814 | C/T | — | uncertain significance |
| rs34865655 | 15:41,192,839 | G/A | — | likely benign |
| rs1892338739 | 15:41,192,874 | C/T | — | uncertain significance |
| rs770920167 | 15:41,193,000 | G/A | — | uncertain significance |
| rs750051348 | 15:41,193,039 | C/G | — | uncertain significance |
| rs762612083 | 15:41,193,040 | G/A | — | likely benign |
| rs2542514418 | 15:41,193,052 | T/G | — | uncertain significance |
| rs373083980 | 15:41,193,090 | C/T | — | uncertain significance |
| rs778923086 | 15:41,193,097 | A/G | — | uncertain significance |
| rs767098206 | 15:41,193,129 | G/A | — | uncertain significance |
| rs753659092 | 15:41,193,147 | C/T | — | uncertain significance |
| rs12914973 | 15:41,193,149 | C/T | — | likely benign |
| rs1441879123 | 15:41,194,903 | C/G | — | uncertain significance |
| rs141929948 | 15:41,194,926 | T/C | — | uncertain significance |
| rs150749198 | 15:41,194,927 | A/G | — | benign |
| rs1892389257 | 15:41,195,236 | G/T | — | uncertain significance |
| rs2542518666 | 15:41,195,241 | A/G | — | uncertain significance |
| rs769878240 | 15:41,195,340 | C/T | — | uncertain significance |
| rs1407511403 | 15:41,195,391 | C/T | — | uncertain significance |
| rs559049517 | 15:41,195,474 | C/G | — | uncertain significance |
| rs143629720 | 15:41,195,483 | G/A | — | uncertain significance |
| rs199642045 | 15:41,195,487 | G/A | — | uncertain significance |
| rs746302473 | 15:41,195,498 | G/T | — | uncertain significance |
| rs8036965 | 15:41,196,329 | T/G | regulatory region variant | — |
| rs8036080 | 15:41,196,384 | G/A | regulatory region variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.