VSIG4

V-set and immunoglobulin domain containing 4

Summary

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Known Variants40 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1044165X:65,241,726G/Adownstream gene variant
rs768192114X:65,241,978G/Alikely benign
rs2519486475X:65,242,130G/Tuncertain significance
rs41307375X:65,242,157G/Abenign
rs202152888X:65,242,170G/Auncertain significance
rs181375443X:65,242,173C/Tuncertain significance
rs781575068X:65,242,698A/Guncertain significance
rs760685843X:65,247,332G/Auncertain significance
rs41305395X:65,247,333T/Auncertain significance
rs141926571X:65,247,362G/Cuncertain significance
rs753126202X:65,247,375A/Glikely benign
rs201039111X:65,247,884A/Glikely benign
rs200800442X:65,247,913T/Auncertain significance
rs1020686087X:65,247,919G/Cuncertain significance
rs778725503X:65,247,927G/Auncertain significance
rs747929072X:65,247,951G/Auncertain significance
rs5965085X:65,248,392G/Aintron variant
rs202001357X:65,252,303C/Tlikely benign
rs749453785X:65,252,335G/Tuncertain significance
rs142891800X:65,252,360C/Tuncertain significance
rs546351019X:65,252,391C/Tuncertain significance
rs749607769X:65,252,401C/Tlikely benign
rs373148029X:65,252,414A/Tlikely benign
rs201461141X:65,252,524C/Auncertain significance
rs142681306X:65,252,601A/Cbenign
rs147670940X:65,252,953C/Tintron variant
rs2519508248X:65,253,320C/Tlikely benign
rs375659869X:65,253,364C/Guncertain significance
rs34581041X:65,253,406G/Abenign
rs778039131X:65,253,426C/Tlikely benign
rs2519508799X:65,253,438G/Auncertain significance
rs41306131X:65,253,454C/Abenign
rs150979129X:65,253,614A/Tuncertain significance
rs749206075X:65,253,634G/Alikely benign
rs2519509494X:65,253,637C/Tuncertain significance
rs201236670X:65,253,670G/Aconflicting classifications of pathogenicity
rs2519509632X:65,253,676A/Glikely benign
rs754269568X:65,253,682C/Tlikely benign
rs1359179547X:65,259,798C/Auncertain significance
rs199904204X:65,259,810C/Tbenign

Gene information from NCBI Gene. Variant classifications from ClinVar.