WARS1
tryptophanyl-tRNA synthetase 1
Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Known Variants85 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs79878944 | 14:100,801,230 | C/A | — | likely benign |
| rs1434881903 | 14:100,801,275 | C/A | — | uncertain significance |
| rs1893606098 | 14:100,801,280 | T/G | — | uncertain significance |
| rs372639869 | 14:100,801,282 | C/T | — | uncertain significance |
| rs749896038 | 14:100,801,286 | G/A | — | uncertain significance |
| rs2549222113 | 14:100,801,322 | C/T | — | uncertain significance |
| rs72713916 | 14:100,801,331 | C/T | — | conflicting classifications of pathogenicity |
| rs550196955 | 14:100,801,373 | C/T | — | likely pathogenic |
| rs2234532 | 14:100,801,423 | T/C | — | benign |
| rs45565635 | 14:100,801,501 | G/C | — | benign |
| rs116564785 | 14:100,801,544 | A/G | — | benign |
| rs10142340 | 14:100,802,485 | T/A | — | — |
| rs2234530 | 14:100,803,364 | A/G | — | benign |
| rs773636381 | 14:100,803,405 | G/C | — | uncertain significance |
| rs777322305 | 14:100,803,418 | T/C | — | likely benign |
| rs150963629 | 14:100,803,422 | C/T | — | conflicting classifications of pathogenicity |
| rs2234529 | 14:100,803,423 | G/A | — | likely benign |
| rs149689884 | 14:100,803,498 | C/A | — | uncertain significance |
| rs2234528 | 14:100,803,655 | C/A | — | benign |
| rs4905951 | 14:100,803,682 | T/C | — | benign |
| rs11622361 | 14:100,803,742 | C/G | — | benign |
| rs35384251 | 14:100,807,273 | C/G | — | — |
| rs149903755 | 14:100,808,726 | A/G | — | likely benign |
| rs1437700113 | 14:100,808,785 | G/A | — | uncertain significance |
| rs2549240295 | 14:100,808,786 | G/T | — | uncertain significance |
| rs779540514 | 14:100,808,790 | C/G | — | uncertain significance |
| rs74085075 | 14:100,808,810 | G/C | — | likely benign |
| rs9453 | 14:100,808,845 | G/A | — | benign |
| rs2549240480 | 14:100,808,851 | C/T | — | uncertain significance |
| rs962736815 | 14:100,808,881 | C/T | — | uncertain significance |
| rs2139921550 | 14:100,808,884 | C/T | — | uncertain significance |
| rs1894240526 | 14:100,808,907 | T/C | — | no classifications from unflagged records |
| rs78299025 | 14:100,809,065 | A/T | — | benign |
| rs549798901 | 14:100,809,658 | C/T | — | likely benign |
| rs941707983 | 14:100,809,676 | G/A | — | uncertain significance |
| rs2549242563 | 14:100,809,710 | G/A | — | uncertain significance |
| rs2139927654 | 14:100,809,724 | C/T | — | likely pathogenic |
| rs115256445 | 14:100,812,505 | A/T | — | — |
| rs941923 | 14:100,813,077 | T/C | — | benign |
| rs143639252 | 14:100,813,092 | C/T | — | uncertain significance |
| rs745994082 | 14:100,813,137 | C/T | — | uncertain significance |
| rs770003315 | 14:100,813,139 | T/C | missense variant | pathogenic |
| rs3783341 | 14:100,816,964 | G/C | intron variant | — |
| rs111245176 | 14:100,818,329 | C/T | — | — |
| rs2549264833 | 14:100,820,036 | A/T | — | uncertain significance |
| rs138324067 | 14:100,820,049 | T/C | — | conflicting classifications of pathogenicity |
| rs2140002463 | 14:100,820,050 | G/C | — | uncertain significance |
| rs2549264966 | 14:100,820,072 | C/G | — | uncertain significance |
| rs752889460 | 14:100,820,080 | G/A | — | likely benign |
| rs2549265193 | 14:100,820,118 | C/A | — | uncertain significance |
| rs1248625678 | 14:100,820,147 | T/C | — | uncertain significance |
| rs199806688 | 14:100,820,803 | T/C | — | uncertain significance |
| rs900952698 | 14:100,820,841 | C/T | — | uncertain significance |
| rs201005516 | 14:100,820,880 | G/T | — | uncertain significance |
| rs2549267216 | 14:100,820,886 | A/C | — | uncertain significance |
| rs2549267217 | 14:100,820,887 | G/C | — | uncertain significance |
| rs1197465536 | 14:100,820,891 | C/A | — | uncertain significance |
| rs1009812 | 14:100,820,980 | G/A | — | benign |
| rs2234524 | 14:100,826,773 | C/G | — | benign |
| rs1895599490 | 14:100,826,900 | A/T | — | no classifications from unflagged records |
| rs200626784 | 14:100,826,906 | A/G | — | uncertain significance |
| rs925136221 | 14:100,826,915 | C/T | — | uncertain significance |
| rs764391035 | 14:100,826,916 | G/A | — | uncertain significance |
| rs2549280507 | 14:100,826,954 | A/G | — | uncertain significance |
| rs1412389611 | 14:100,826,958 | G/A | — | uncertain significance |
| rs201676413 | 14:100,826,974 | G/T | — | uncertain significance |
| rs1484613779 | 14:100,826,996 | C/A | — | uncertain significance |
| rs1355056839 | 14:100,826,997 | G/A | — | uncertain significance |
| rs754416760 | 14:100,828,040 | C/T | — | likely benign |
| rs747714098 | 14:100,828,046 | A/T | — | likely benign |
| rs1256472633 | 14:100,828,055 | A/G | — | likely benign |
| rs771708813 | 14:100,828,057 | C/T | — | uncertain significance |
| rs748585136 | 14:100,828,077 | C/T | — | uncertain significance |
| rs140996628 | 14:100,828,122 | T/A | — | uncertain significance |
| rs149405219 | 14:100,828,196 | C/T | — | likely benign |
| rs2234521 | 14:100,828,198 | C/T | — | likely benign |
| rs371310773 | 14:100,828,228 | C/G | — | likely benign |
| rs2400898 | 14:100,828,397 | T/C | — | benign |
| rs12888855 | 14:100,830,818 | C/A | upstream gene variant | — |
| rs146689917 | 14:100,835,456 | C/T | — | uncertain significance |
| rs143974221 | 14:100,835,498 | G/C | — | likely benign |
| rs2549306131 | 14:100,835,522 | T/C | — | pathogenic |
| rs3783347 | 14:100,839,261 | G/T | upstream gene variant | — |
| rs17554326 | 14:100,842,377 | A/G | regulatory region variant | — |
| rs12892634 | 14:100,843,888 | C/A | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.