WARS2

tryptophanyl tRNA synthetase 2, mitochondrial

Summary

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Known Variants137 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs3790548	1:119,575,297	G/C	—	benign
rs17023101	1:119,575,538	A/G	—	benign
rs563341344	1:119,575,563	C/T	—	uncertain significance
rs1647552297	1:119,575,587	C/A	—	uncertain significance
rs1647554050	1:119,575,601	G/A	—	uncertain significance
rs1332510652	1:119,575,602	A/T	—	uncertain significance
rs1370759242	1:119,575,604	C/G	—	uncertain significance
rs1448970558	1:119,575,607	A/G	—	uncertain significance
rs1046598440	1:119,575,629	G/A	—	uncertain significance
rs151047248	1:119,575,654	A/T	—	likely benign
rs376728283	1:119,575,661	C/T	—	uncertain significance
rs75040541	1:119,575,668	T/C	—	uncertain significance
rs145867327	1:119,575,679	T/A	missense variant	pathogenic
rs139467678	1:119,575,687	C/T	—	benign
rs932382697	1:119,575,692	C/A	—	uncertain significance
rs370628159	1:119,575,718	G/A	—	uncertain significance
rs2524937019	1:119,575,730	C/A	—	uncertain significance
rs946355135	1:119,575,732	C/T	—	likely benign
rs140469836	1:119,575,733	G/A	—	uncertain significance
rs1165413282	1:119,575,735	G/T	—	uncertain significance
rs374026714	1:119,575,740	G/A	—	uncertain significance
rs747204006	1:119,575,742	C/T	—	uncertain significance
rs201132666	1:119,575,743	G/A	—	uncertain significance
rs192289549	1:119,575,758	C/T	—	likely benign
rs2524937423	1:119,575,759	G/C	—	likely benign
rs202238245	1:119,575,765	C/G	—	likely benign
rs772131113	1:119,575,768	C/G	—	likely benign
rs2524937656	1:119,575,773	C/T	—	uncertain significance
rs952768523	1:119,575,776	C/T	—	uncertain significance
rs765904496	1:119,575,784	A/C	—	likely pathogenic
rs1003432838	1:119,575,786	C/G	—	likely benign
rs2101094457	1:119,575,793	A/G	—	uncertain significance
rs553905810	1:119,575,803	C/T	—	uncertain significance
rs545906519	1:119,575,811	C/T	—	uncertain significance
rs3790549	1:119,575,818	C/G	—	benign
rs768587458	1:119,575,819	C/T	—	likely benign
rs368914534	1:119,575,820	G/A	—	uncertain significance
rs139194636	1:119,575,826	T/C	missense variant	pathogenic
rs772986745	1:119,575,838	G/A	—	uncertain significance
rs765994519	1:119,575,862	C/T	—	uncertain significance
rs149657255	1:119,575,863	G/A	—	conflicting classifications of pathogenicity
rs1557929151	1:119,575,866	A/G	—	uncertain significance
rs751913292	1:119,575,901	C/T	—	uncertain significance
rs757600616	1:119,575,902	G/A	stop gained	pathogenic
rs1300524106	1:119,575,905	C/T	—	uncertain significance
rs1571246959	1:119,575,913	A/T	—	uncertain significance
rs750645277	1:119,575,923	G/T	—	uncertain significance
rs77497675	1:119,575,933	C/T	—	benign
rs1647600390	1:119,575,934	G/C	—	uncertain significance
rs2101095108	1:119,575,937	A/G	—	likely pathogenic
rs1647601318	1:119,575,952	T/C	—	uncertain significance
rs1647606364	1:119,575,983	C/T	—	uncertain significance
rs1284238050	1:119,576,001	C/A	—	likely benign
rs137890886	1:119,576,730	C/A	—	pathogenic
rs932112855	1:119,576,731	G/A	—	likely benign
rs145843390	1:119,576,796	T/C	—	conflicting classifications of pathogenicity
rs2524947668	1:119,576,799	G/T	—	uncertain significance
rs912133959	1:119,576,820	C/G	missense variant	pathogenic
rs745543661	1:119,576,826	C/A	—	likely pathogenic
rs199831668	1:119,576,827	G/A	—	likely benign
rs17023108	1:119,576,904	G/A	—	benign
rs2247883	1:119,577,837	A/T	intron variant	—
rs2525003563	1:119,584,901	G/A	—	likely benign
rs2525003665	1:119,584,908	G/A	—	uncertain significance
rs570439512	1:119,584,915	G/A	—	uncertain significance
rs149281638	1:119,584,919	T/C	—	benign
rs762541487	1:119,584,933	G/A	—	likely benign
rs140008988	1:119,584,935	C/T	—	uncertain significance
rs33960696	1:119,584,949	A/G	—	benign
rs150022801	1:119,584,950	T/C	—	likely benign
rs149201054	1:119,584,960	T/C	—	uncertain significance
rs143494742	1:119,584,989	G/C	—	likely benign
rs1648723584	1:119,588,195	T/A	—	likely benign
rs147962776	1:119,588,230	C/T	—	conflicting classifications of pathogenicity
rs777267723	1:119,588,235	T/C	—	likely benign
rs184828552	1:119,588,262	A/G	—	likely benign
rs1648733523	1:119,588,266	A/C	—	likely pathogenic
rs778680858	1:119,588,268	T/C	—	likely benign
rs745550081	1:119,588,271	T/C	—	likely benign
rs1648735933	1:119,588,276	G/T	—	uncertain significance
rs1651726480	1:119,618,955	C/T	—	likely benign
rs200060157	1:119,618,970	G/A	—	uncertain significance
rs745462502	1:119,619,000	T/C	—	likely benign
rs758130195	1:119,619,003	C/T	—	likely benign
rs753188889	1:119,619,004	G/A	—	uncertain significance
rs1651732458	1:119,619,008	T/C	—	uncertain significance
rs2525266510	1:119,619,024	A/G	—	likely benign
rs374597293	1:119,619,056	G/A	—	uncertain significance
rs776400244	1:119,619,068	G/A	—	likely benign
rs368451564	1:119,619,073	T/C	—	uncertain significance
rs142739265	1:119,619,077	G/C	—	uncertain significance
rs2525267356	1:119,619,080	C/T	—	uncertain significance
rs766501807	1:119,619,090	G/C	—	uncertain significance
rs1376745156	1:119,619,107	T/C	—	uncertain significance
rs923069804	1:119,619,116	C/G	—	uncertain significance
rs149515458	1:119,619,122	C/G	—	benign
rs1224122076	1:119,619,126	T/C	—	likely benign
rs2101319201	1:119,619,128	C/A	—	uncertain significance
rs2525268258	1:119,619,147	G/A	—	likely benign
rs1163806887	1:119,619,165	G/A	—	likely benign

Showing 100 of 137 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.