WDR11

WD repeat domain 11

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]

Known Variants337 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs10886785	10:122,610,391	C/G	—	benign
rs149036466	10:122,610,430	C/T	—	likely benign
rs74158326	10:122,610,636	G/A	—	likely benign
rs12778011	10:122,610,639	T/G	—	benign
rs1659597	10:122,610,646	C/A	—	benign
rs11199598	10:122,610,657	T/C	—	benign
rs78953227	10:122,610,782	A/G	—	benign
rs12267610	10:122,610,787	T/A	—	benign
rs17100983	10:122,610,793	C/T	—	benign
rs17100985	10:122,610,927	G/A	—	benign
rs112459242	10:122,610,930	G/A	—	benign
rs758182867	10:122,610,938	G/T	—	conflicting classifications of pathogenicity
rs777677898	10:122,610,939	C/T	—	uncertain significance
rs2493226251	10:122,610,940	C/G	—	uncertain significance
rs780739420	10:122,610,948	G/A	—	uncertain significance
rs1184796114	10:122,610,965	G/C	—	likely benign
rs35692153	10:122,610,983	G/T	—	benign
rs2493226487	10:122,610,991	A/G	—	uncertain significance
rs1476909700	10:122,610,997	A/C	—	uncertain significance
rs2133715854	10:122,611,008	G/A	—	uncertain significance
rs891562062	10:122,611,026	C/T	—	likely benign
rs78163411	10:122,611,046	A/G	—	likely benign
rs138483371	10:122,611,161	T/C	—	likely benign
rs7917351	10:122,611,772	A/T	—	benign
rs776728184	10:122,612,058	T/C	—	uncertain significance
rs2493231150	10:122,612,121	G/A	—	uncertain significance
rs41287984	10:122,612,470	G/A	—	benign
rs2241846	10:122,618,148	G/C	—	benign
rs1224504208	10:122,618,185	A/G	—	uncertain significance
rs143876241	10:122,618,210	G/C	—	uncertain significance
rs147244489	10:122,618,244	C/T	—	likely benign
rs372051040	10:122,618,245	G/A	—	uncertain significance
rs1300089213	10:122,618,264	G/A	—	uncertain significance
rs2493248036	10:122,618,300	C/G	—	uncertain significance
rs1385978579	10:122,618,302	A/G	—	uncertain significance
rs775474626	10:122,618,309	G/A	—	likely pathogenic
rs1254155	10:122,618,561	A/G	—	benign
rs55968513	10:122,618,579	A/T	—	benign
rs1846091309	10:122,619,641	C/T	—	uncertain significance
rs200398973	10:122,619,662	C/G	—	uncertain significance
rs1421777263	10:122,619,671	A/G	—	uncertain significance
rs374824479	10:122,619,679	G/A	—	likely benign
rs780075067	10:122,619,708	A/G	—	uncertain significance
rs148635545	10:122,619,724	A/G	—	likely benign
rs1846095119	10:122,619,734	A/T	—	uncertain significance
rs148704547	10:122,619,739	T/C	—	likely benign
rs770949613	10:122,619,744	A/T	—	uncertain significance
rs2493252474	10:122,619,766	T/G	—	uncertain significance
rs7098449	10:122,619,877	C/T	—	benign
rs61875072	10:122,619,930	A/G	—	benign
rs74158331	10:122,622,008	T/C	—	benign
rs74158332	10:122,622,108	C/A	—	benign
rs3816173	10:122,622,121	A/C	—	benign
rs138588847	10:122,622,257	C/T	—	benign
rs1429640312	10:122,622,262	G/C	—	uncertain significance
rs140904601	10:122,622,364	T/C	—	uncertain significance
rs2133740277	10:122,622,393	C/G	—	uncertain significance
rs143224552	10:122,622,428	A/G	—	likely benign
rs771423568	10:122,622,442	C/G	—	likely benign
rs7076911	10:122,624,270	T/C	—	benign
rs2133744158	10:122,624,564	A/G	—	uncertain significance
rs778732282	10:122,624,579	A/G	—	uncertain significance
rs2493265423	10:122,624,584	T/G	—	uncertain significance
rs1564943019	10:122,624,593	T/C	—	likely benign
rs2493265485	10:122,624,601	C/A	—	uncertain significance
rs746465459	10:122,624,615	G/C	—	uncertain significance
rs201708765	10:122,624,616	G/A	—	likely benign
rs560536574	10:122,624,634	C/A	—	likely benign
rs774442833	10:122,624,642	G/C	—	uncertain significance
rs753755460	10:122,624,678	C/T	—	uncertain significance
rs10886789	10:122,624,679	G/A	—	benign
rs758145169	10:122,624,694	A/G	—	likely benign
rs780896580	10:122,624,702	G/A	—	uncertain significance
rs1260933034	10:122,624,704	A/G	—	uncertain significance
rs562880069	10:122,624,714	C/A	—	uncertain significance
rs770383841	10:122,624,722	C/G	—	uncertain significance
rs7920304	10:122,625,035	A/G	—	benign
rs187463420	10:122,625,130	A/G	—	benign
rs377167358	10:122,625,161	G/A	—	uncertain significance
rs2133745425	10:122,625,170	T/C	—	uncertain significance
rs1323199873	10:122,625,181	C/T	—	uncertain significance
rs2493267693	10:122,625,188	A/G	—	uncertain significance
rs1443712298	10:122,625,247	G/A	—	uncertain significance
rs11199606	10:122,625,517	T/C	—	benign
rs73368178	10:122,625,839	A/G	—	likely benign
rs2289335	10:122,626,038	C/T	—	benign
rs187738542	10:122,626,046	C/T	—	likely benign
rs765892068	10:122,626,146	A/G	—	uncertain significance
rs34304988	10:122,626,152	G/A	—	likely benign
rs2493270915	10:122,626,165	G/A	—	uncertain significance
rs41287986	10:122,626,199	C/T	—	likely benign
rs150630318	10:122,626,224	G/A	—	conflicting classifications of pathogenicity
rs375696471	10:122,626,260	C/A	—	likely benign
rs200429003	10:122,626,261	G/A	—	uncertain significance
rs201051480	10:122,626,269	C/T	—	uncertain significance
rs138817330	10:122,626,527	G/A	—	likely benign
rs1027136761	10:122,626,613	C/G	—	uncertain significance
rs1342502471	10:122,626,620	T/G	—	uncertain significance
rs2133748193	10:122,626,642	C/T	—	pathogenic
rs1238508616	10:122,626,667	T/G	—	pathogenic

Showing 100 of 337 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.