WDR26

WD repeat domain 26

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Known Variants129 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs1553350638	1:224,577,556	C/A	—	uncertain significance
rs12048758	1:224,579,048	A/T	—	—
rs752459782	1:224,581,541	T/C	—	uncertain significance
rs142326612	1:224,581,555	A/G	—	likely benign
rs1673189476	1:224,581,586	T/C	—	pathogenic
rs1264925644	1:224,581,608	T/C	—	uncertain significance
rs2464664308	1:224,581,661	G/A	—	uncertain significance
rs35958886	1:224,581,681	T/C	—	benign
rs1673192650	1:224,581,696	C/T	—	pathogenic
rs2464678543	1:224,585,810	C/T	—	uncertain significance
rs370131674	1:224,585,814	C/T	—	likely benign
rs2464678578	1:224,585,826	C/T	—	uncertain significance
rs2464678646	1:224,585,847	A/C	—	uncertain significance
rs762877427	1:224,585,910	A/C	—	uncertain significance
rs7522956	1:224,585,958	A/C	—	benign
rs1673322799	1:224,586,216	C/G	—	pathogenic
rs760399308	1:224,586,245	C/T	—	uncertain significance
rs1316172731	1:224,586,273	T/A	—	uncertain significance
rs1553353230	1:224,586,291	G/C	—	uncertain significance
rs1302926249	1:224,586,621	T/C	—	uncertain significance
rs1673333616	1:224,586,627	C/T	—	likely pathogenic
rs2102891563	1:224,586,634	G/A	—	pathogenic
rs1673333759	1:224,586,642	G/A	—	uncertain significance
rs528360727	1:224,586,644	A/T	—	uncertain significance
rs1265462349	1:224,586,660	G/A	—	uncertain significance
rs2464682792	1:224,586,672	C/T	—	uncertain significance
rs2464682825	1:224,586,680	C/T	—	pathogenic
rs2464688165	1:224,588,669	C/T	—	uncertain significance
rs1572168244	1:224,588,677	C/A	—	likely pathogenic
rs2464688237	1:224,588,698	C/T	—	uncertain significance
rs2464688249	1:224,588,702	C/G	—	uncertain significance
rs2102894017	1:224,588,729	T/C	—	uncertain significance
rs140546120	1:224,588,736	A/G	—	likely benign
rs2464688338	1:224,588,741	A/T	—	likely benign
rs1673399471	1:224,588,774	A/G	—	uncertain significance
rs2464697236	1:224,592,145	A/G	—	uncertain significance
rs1553354926	1:224,592,155	C/A	—	pathogenic
rs2464697289	1:224,592,172	C/A	—	uncertain significance
rs2102897778	1:224,592,175	C/T	—	likely pathogenic
rs767723808	1:224,592,187	T/G	—	uncertain significance
rs1553354952	1:224,592,194	C/T	—	likely pathogenic
rs1553354956	1:224,592,206	A/C	—	likely pathogenic
rs933720635	1:224,592,221	C/T	—	uncertain significance
rs1673500565	1:224,592,243	T/C	—	likely benign
rs374760855	1:224,592,263	G/C	—	uncertain significance
rs1416577860	1:224,599,126	T/C	—	uncertain significance
rs1673733539	1:224,599,128	C/T	—	pathogenic
rs144934464	1:224,599,129	C/T	—	uncertain significance
rs752279779	1:224,599,130	G/A	—	uncertain significance
rs2464720371	1:224,599,141	C/T	—	likely pathogenic
rs1673734199	1:224,599,144	T/C	—	uncertain significance
rs2464720387	1:224,599,146	T/C	—	uncertain significance
rs2102905325	1:224,599,176	C/G	—	likely pathogenic
rs2102905337	1:224,599,198	G/C	—	uncertain significance
rs2464720512	1:224,599,211	C/T	—	pathogenic
rs2102905355	1:224,599,226	T/C	—	uncertain significance
rs532004418	1:224,599,232	G/A	—	uncertain significance
rs748379928	1:224,599,249	A/G	—	likely benign
rs7527044	1:224,602,243	G/T	intron variant	—
rs1673963444	1:224,605,961	C/T	—	pathogenic
rs1673963487	1:224,605,964	A/C	—	uncertain significance
rs2102912811	1:224,606,010	T/C	—	conflicting classifications of pathogenicity
rs779410378	1:224,606,037	C/T	—	uncertain significance
rs374705168	1:224,606,065	G/A	—	uncertain significance
rs2464743516	1:224,606,077	G/A	—	pathogenic
rs2102912929	1:224,606,083	G/A	—	uncertain significance
rs1673967254	1:224,606,085	C/T	—	conflicting classifications of pathogenicity
rs2102912948	1:224,606,119	C/T	—	likely pathogenic
rs2464743688	1:224,606,132	T/C	—	likely benign
rs1553359384	1:224,607,232	C/T	—	pathogenic
rs774272467	1:224,607,246	C/T	—	uncertain significance
rs2102914069	1:224,607,269	C/T	—	pathogenic
rs2464746975	1:224,607,271	A/G	—	uncertain significance
rs2464747078	1:224,607,300	T/C	—	likely pathogenic
rs2464747128	1:224,607,309	A/G	—	uncertain significance
rs150512167	1:224,612,222	A/C	missense variant	pathogenic
rs2464762505	1:224,612,234	A/C	—	uncertain significance
rs1674157422	1:224,612,239	G/A	—	uncertain significance
rs1674157739	1:224,612,248	T/G	—	uncertain significance
rs1417677519	1:224,612,259	G/A	—	conflicting classifications of pathogenicity
rs1401923084	1:224,612,262	G/A	—	uncertain significance
rs2102919542	1:224,612,278	G/C	—	conflicting classifications of pathogenicity
rs921233431	1:224,612,296	G/C	—	uncertain significance
rs2102919579	1:224,612,347	A/C	—	uncertain significance
rs796052140	1:224,619,194	C/A	—	uncertain significance
rs2102926330	1:224,619,249	A/G	—	uncertain significance
rs1674395504	1:224,619,293	T/C	—	conflicting classifications of pathogenicity
rs2464784617	1:224,619,386	T/C	—	uncertain significance
rs2405033	1:224,621,368	G/C	—	benign
rs1016228867	1:224,621,453	G/A	—	uncertain significance
rs887635852	1:224,621,456	T/G	—	uncertain significance
rs765417177	1:224,621,504	A/C	—	likely benign
rs571231334	1:224,621,505	G/A	—	likely benign
rs2464795629	1:224,621,510	C/T	—	uncertain significance
rs2464795750	1:224,621,522	A/C	—	uncertain significance
rs375450160	1:224,621,533	A/G	—	likely benign
rs202205027	1:224,621,538	G/A	—	benign
rs1558450796	1:224,621,542	G/A	—	uncertain significance
rs1674496698	1:224,621,546	A/C	—	likely benign
rs1332019893	1:224,621,549	C/A	—	uncertain significance

Showing 100 of 129 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.