WDR37

WD repeat domain 37

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

Known Variants72 total

rsidPosition (GRCh37)AllelesClassClinVar
rs18331628310:1,114,021G/Aintron variant—
rs75103987410:1,118,110C/T—likely benign
rs20065714110:1,118,121C/T—uncertain significance
rs94782909410:1,118,147C/T—uncertain significance
rs141282272610:1,118,174A/G—uncertain significance
rs183375273610:1,118,200G/A—likely benign
rs134832926010:1,118,243G/A—likely benign
rs77358211910:1,123,866C/T—uncertain significance
rs249065764910:1,123,883C/G—uncertain significance
rs13959323210:1,123,920A/G—likely benign
rs125557692910:1,125,965G/A—uncertain significance
rs75494460510:1,126,026A/G—conflicting classifications of pathogenicity
rs129213556610:1,126,040A/G—uncertain significance
rs183399428410:1,126,364C/T—conflicting classifications of pathogenicity
rs158908869010:1,126,376C/T—pathogenic
rs7357853610:1,126,383A/G—likely benign
rs213162552510:1,126,393A/G—pathogenic
rs155482337510:1,126,394C/T—pathogenic
rs158908870210:1,126,406C/G—likely pathogenic
rs158908870310:1,126,409C/T—pathogenic
rs213163055610:1,130,352A/T—likely pathogenic
rs75700986310:1,130,365C/T—uncertain significance
rs14586143810:1,130,375A/G—likely benign
rs249067865010:1,130,431T/G—uncertain significance
rs76544897710:1,130,439G/A—uncertain significance
rs74556220710:1,130,469G/T—uncertain significance
rs14516056010:1,130,477C/T—likely benign
rs14348498810:1,132,232C/T—likely benign
rs213164602610:1,142,119A/G—likely pathogenic
rs37591350910:1,142,146C/T—likely benign
rs76144736010:1,142,154C/G—uncertain significance
rs75371813610:1,142,181A/G—uncertain significance
rs1079471610:1,142,208T/C—benign
rs249074869310:1,149,555A/G—uncertain significance
rs183489613110:1,149,585C/A—uncertain significance
rs183489640510:1,149,590C/G—likely benign
rs131166450910:1,149,593G/A—likely pathogenic
rs94195558310:1,149,615G/C—uncertain significance
rs158911019810:1,149,620A/G—uncertain significance
rs75814183010:1,149,623A/G—uncertain significance
rs146925633610:1,149,644C/T—uncertain significance
rs213166206210:1,149,665G/T—uncertain significance
rs74662622310:1,149,671G/A—likely benign
rs77816852610:1,149,687T/C—likely benign
rs127724502710:1,149,696A/T—uncertain significance
rs249074930610:1,149,735T/C—uncertain significance
rs74732519610:1,149,739C/T—likely benign
rs101853663010:1,149,743G/A—uncertain significance
rs249074934210:1,149,749A/T—uncertain significance
rs56721629510:1,149,761G/A—likely benign
rs78101288910:1,151,067G/T—likely benign
rs249075325410:1,151,075A/G—uncertain significance
rs77888338810:1,151,177A/C—uncertain significance
rs145416100410:1,151,187T/C—likely benign
rs37733338710:1,151,217G/A—uncertain significance
rs1079472010:1,156,165T/Cregulatory region variant—
rs95970404010:1,170,193A/G—uncertain significance
rs75464447310:1,170,209C/T—likely benign
rs76482788510:1,170,210G/T—uncertain significance
rs20177358510:1,170,220C/T—likely benign
rs57521137910:1,170,230C/T—likely benign
rs118112445610:1,170,271G/A—uncertain significance
rs13832379010:1,170,841T/A—benign
rs14225225310:1,170,855A/G—likely benign
rs37230614910:1,170,866G/A—likely benign
rs77524877210:1,170,871A/T—uncertain significance
rs183590220510:1,175,166T/C—uncertain significance
rs7149134110:1,175,180G/T—likely benign
rs14567752810:1,175,182A/G—likely benign
rs74854337010:1,175,195C/T—uncertain significance
rs126521981210:1,175,243G/C—uncertain significance
rs249083883310:1,175,244G/C—uncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.