WDR49

WD repeat domain 49

Summary

This gene encodes a member of the WD repeat protein family with nine WD repeats. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Known Variants60 total

rsidPosition (GRCh37)AllelesClassClinVar
rs1511397033:167,196,695T/Auncertain significance
rs14156404053:167,196,744C/Guncertain significance
rs7611484353:167,196,772A/Guncertain significance
rs1125238833:167,215,779G/A
rs17515033733:167,217,943T/Cuncertain significance
rs13327618023:167,217,955G/Auncertain significance
rs12163661513:167,217,965G/Tuncertain significance
rs24751611653:167,217,980C/Tuncertain significance
rs10520178943:167,218,078C/Guncertain significance
rs12427685703:167,223,108T/Cuncertain significance
rs12334815253:167,223,153A/Tuncertain significance
rs1433048783:167,223,184A/Guncertain significance
rs17524806643:167,240,124T/Cuncertain significance
rs1999172003:167,240,151G/Cuncertain significance
rs2022256463:167,240,215C/Tlikely benign
rs1498652363:167,245,655T/Clikely benign
rs7667510993:167,245,661A/Guncertain significance
rs1397732383:167,245,724T/Cuncertain significance
rs7720529353:167,245,726C/Tlikely benign
rs1939211013:167,245,747G/Tuncertain significance
rs1395886963:167,245,765G/Auncertain significance
rs9459309723:167,245,799A/Tuncertain significance
rs7641552723:167,245,803C/Auncertain significance
rs7662581743:167,246,907G/Cuncertain significance
rs3695592893:167,246,967T/Cuncertain significance
rs24752455323:167,246,983A/Guncertain significance
rs1439896883:167,246,997G/Tuncertain significance
rs5321820423:167,248,948T/Cuncertain significance
rs2019847263:167,248,971T/Cuncertain significance
rs1996774793:167,248,986C/Tlikely benign
rs1510838513:167,248,995G/Alikely benign
rs24752522723:167,249,023A/Guncertain significance
rs3769029003:167,249,038C/Auncertain significance
rs9965752823:167,250,709C/Tuncertain significance
rs17529013783:167,250,751C/Guncertain significance
rs7517540163:167,254,694A/Guncertain significance
rs7786594843:167,254,730A/Guncertain significance
rs7630573773:167,254,784T/Cuncertain significance
rs13982258403:167,254,787C/Tuncertain significance
rs7584129583:167,272,480C/Guncertain significance
rs14135743133:167,277,866C/Tuncertain significance
rs3683828653:167,277,871C/Auncertain significance
rs1414961843:167,277,887G/Auncertain significance
rs7805951723:167,277,916C/Tuncertain significance
rs2012060223:167,277,932C/Tuncertain significance
rs1381760133:167,277,949T/Guncertain significance
rs7569073183:167,277,980A/Guncertain significance
rs1437180573:167,277,985G/Auncertain significance
rs558533543:167,283,842A/Gintron variant
rs24753830403:167,293,925C/Guncertain significance
rs2016984563:167,319,938G/Tuncertain significance
rs7737020143:167,320,043T/Cuncertain significance
rs1445034283:167,322,104G/Alikely benign
rs1997551143:167,322,157T/Cuncertain significance
rs1468041083:167,322,164G/Auncertain significance
rs1508381393:167,341,871A/Gintron variant
rs24755141823:167,344,907C/Tlikely benign
rs76272893:167,348,838G/Aintron variant
rs64444473:167,349,004C/Tintron variant
rs68073063:167,373,858C/Gupstream gene variant

Gene information from NCBI Gene. Variant classifications from ClinVar.