WDR59

WD repeat domain 59

Summary

Predicted to enable signaling adaptor activity. Involved in cellular response to amino acid starvation and positive regulation of TORC1 signaling. Located in cytosol and lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants67 total

rsidPosition (GRCh37)AllelesClassClinVar
rs6173372416:74,908,146G/Abenign
rs20109590716:74,908,213G/Tuncertain significance
rs19969387716:74,908,226T/Cuncertain significance
rs77656627416:74,908,231G/Auncertain significance
rs36895109616:74,908,285A/Guncertain significance
rs14756538316:74,908,297G/Auncertain significance
rs14494894916:74,908,315C/Tuncertain significance
rs11278218216:74,918,674T/G
rs75600345016:74,919,557C/Guncertain significance
rs250713744416:74,919,575G/Auncertain significance
rs75908399416:74,920,205G/Auncertain significance
rs6173372616:74,921,593C/Abenign
rs76193346216:74,922,101C/Tuncertain significance
rs76761077216:74,922,102G/Auncertain significance
rs994042216:74,922,106A/Gbenign
rs76737147716:74,922,194C/Tuncertain significance
rs76115445116:74,922,195G/Auncertain significance
rs14423866316:74,922,200C/Tlikely benign
rs75599364216:74,922,206T/Cuncertain significance
rs14915677116:74,923,697G/Auncertain significance
rs75122141916:74,923,706G/Auncertain significance
rs14504144916:74,926,406G/Alikely benign
rs77820383516:74,927,595G/Auncertain significance
rs92262082216:74,927,600G/Cuncertain significance
rs77525146916:74,927,635T/Cuncertain significance
rs77907876916:74,927,661C/Tuncertain significance
rs37608698016:74,927,685C/Tuncertain significance
rs14566475816:74,927,691C/Tuncertain significance
rs20123481916:74,937,942C/Tuncertain significance
rs196568632216:74,937,958C/Tuncertain significance
rs20196515516:74,942,828A/Guncertain significance
rs76614463616:74,942,833G/Auncertain significance
rs75369650416:74,942,836C/Tuncertain significance
rs54415524816:74,942,837G/Auncertain significance
rs14799369816:74,942,844T/Clikely benign
rs6173455116:74,943,471T/Cbenign
rs75316984616:74,943,492G/Auncertain significance
rs250716172016:74,943,549C/Tuncertain significance
rs77248095716:74,943,734G/Auncertain significance
rs146075671816:74,946,158G/Tuncertain significance
rs37565449616:74,946,214T/Cuncertain significance
rs138497664316:74,949,876G/Alikely benign
rs6173455316:74,949,890G/Cbenign
rs250720769616:74,950,059A/Tuncertain significance
rs76082390716:74,950,129A/Guncertain significance
rs53917998116:74,950,148T/Guncertain significance
rs145465123516:74,951,834A/Guncertain significance
rs37152511216:74,951,864G/Cuncertain significance
rs94816736116:74,951,882G/Auncertain significance
rs20189717116:74,955,905G/Cuncertain significance
rs11623030516:74,955,911G/Cbenign
rs75173113216:74,957,876T/Cuncertain significance
rs14276019316:74,957,879C/Guncertain significance
rs203052483416:74,957,896C/Auncertain significance
rs77849953416:74,972,055G/Auncertain significance
rs203233230416:74,976,655A/Cuncertain significance
rs20115543116:74,976,680G/Cuncertain significance
rs204241516:74,978,618G/Aintron variant
rs14783139416:74,982,420C/Tuncertain significance
rs77293984116:74,982,434A/Tuncertain significance
rs14375416716:74,983,639G/Alikely benign
rs250736796016:74,985,396C/Tuncertain significance
rs148458547116:74,990,468C/Tuncertain significance
rs74787280616:74,999,704A/Guncertain significance
rs7798563916:74,999,712C/Tbenign
rs37115031116:74,999,713G/Auncertain significance
rs250741689616:74,999,719G/Auncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.