WDTC1
WD and tetratricopeptide repeats 1
Summary
Predicted to enable enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to act upstream of or within several processes, including cellular response to insulin stimulus; glucose metabolic process; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants30 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs181896741 | 1:27,564,845 | C/T | upstream gene variant | — |
| rs187092352 | 1:27,582,059 | C/T | upstream gene variant | — |
| rs78283341 | 1:27,587,551 | G/A | — | benign |
| rs1397182582 | 1:27,587,577 | T/A | — | uncertain significance |
| rs765267043 | 1:27,589,668 | G/A | — | uncertain significance |
| rs201889881 | 1:27,589,733 | G/T | — | benign |
| rs2521875706 | 1:27,618,737 | T/G | — | uncertain significance |
| rs145339479 | 1:27,621,108 | G/T | — | uncertain significance |
| rs773396139 | 1:27,621,110 | G/C | — | uncertain significance |
| rs143803058 | 1:27,622,832 | T/A | — | uncertain significance |
| rs201290829 | 1:27,622,864 | C/T | — | benign |
| rs116268483 | 1:27,623,567 | C/T | — | benign |
| rs745945935 | 1:27,623,590 | A/G | — | uncertain significance |
| rs777597808 | 1:27,623,619 | C/T | — | uncertain significance |
| rs749108073 | 1:27,623,620 | G/A | — | uncertain significance |
| rs770607762 | 1:27,623,626 | C/T | — | uncertain significance |
| rs150230763 | 1:27,624,459 | G/C | — | uncertain significance |
| rs751629370 | 1:27,624,552 | C/A | — | uncertain significance |
| rs375560689 | 1:27,630,139 | C/T | — | uncertain significance |
| rs146854717 | 1:27,630,147 | C/T | — | uncertain significance |
| rs200956178 | 1:27,630,153 | C/T | — | uncertain significance |
| rs41291068 | 1:27,630,160 | C/T | — | uncertain significance |
| rs938226288 | 1:27,630,178 | T/C | — | uncertain significance |
| rs756772525 | 1:27,630,214 | A/G | — | uncertain significance |
| rs2521970551 | 1:27,630,219 | T/C | — | uncertain significance |
| rs2013889181 | 1:27,630,274 | A/C | — | uncertain significance |
| rs781175924 | 1:27,631,619 | A/G | — | uncertain significance |
| rs141668588 | 1:27,631,672 | C/T | — | benign |
| rs1185306321 | 1:27,632,712 | G/T | — | uncertain significance |
| rs199890694 | 1:27,632,816 | C/T | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.