WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
Summary
This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases. [provided by RefSeq, Jul 2008]
Known Variants54 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs374542712 | 16:681,203 | C/T | regulatory region variant | — |
| rs376127399 | 16:681,260 | G/A | — | likely benign |
| rs762714937 | 16:681,269 | C/A | — | uncertain significance |
| rs547572981 | 16:681,296 | C/T | — | uncertain significance |
| rs2506010682 | 16:681,326 | G/C | — | uncertain significance |
| rs1023147765 | 16:681,347 | G/A | — | uncertain significance |
| rs1223301653 | 16:681,360 | A/G | — | uncertain significance |
| rs143772631 | 16:681,383 | G/A | — | uncertain significance |
| rs775302766 | 16:681,407 | G/C | — | uncertain significance |
| rs138836137 | 16:681,414 | G/A | — | uncertain significance |
| rs35800913 | 16:682,041 | C/T | downstream gene variant | — |
| rs757780773 | 16:682,645 | C/T | — | uncertain significance |
| rs149287908 | 16:682,654 | G/A | — | uncertain significance |
| rs2036965169 | 16:682,655 | G/T | — | uncertain significance |
| rs779393776 | 16:682,667 | C/T | — | uncertain significance |
| rs148475508 | 16:682,673 | C/T | — | uncertain significance |
| rs769947524 | 16:682,679 | C/T | — | uncertain significance |
| rs140254693 | 16:682,738 | G/A | — | uncertain significance |
| rs370646237 | 16:682,839 | C/G | — | likely benign |
| rs149216334 | 16:682,855 | G/A | — | uncertain significance |
| rs775276803 | 16:682,870 | A/C | — | uncertain significance |
| rs774157032 | 16:682,873 | G/A | — | uncertain significance |
| rs374779276 | 16:682,901 | C/T | — | uncertain significance |
| rs562663373 | 16:682,913 | C/T | — | uncertain significance |
| rs368611876 | 16:682,926 | G/C | — | uncertain significance |
| rs770735856 | 16:683,032 | G/A | — | uncertain significance |
| rs2506012656 | 16:683,189 | T/G | — | uncertain significance |
| rs544094050 | 16:683,324 | C/T | — | uncertain significance |
| rs374981998 | 16:683,376 | G/T | — | uncertain significance |
| rs2036979758 | 16:683,384 | G/T | — | uncertain significance |
| rs1458547741 | 16:683,405 | G/A | — | uncertain significance |
| rs888953321 | 16:683,426 | G/A | — | uncertain significance |
| rs938048030 | 16:683,428 | G/A | — | uncertain significance |
| rs776412951 | 16:683,446 | G/A | — | uncertain significance |
| rs745474912 | 16:683,500 | G/C | — | uncertain significance |
| rs1040764831 | 16:683,516 | G/C | — | uncertain significance |
| rs372514202 | 16:683,587 | G/A | — | uncertain significance |
| rs781647041 | 16:683,597 | G/A | — | uncertain significance |
| rs537883613 | 16:683,614 | C/T | — | uncertain significance |
| rs763100479 | 16:683,647 | C/G | — | uncertain significance |
| rs374840117 | 16:683,672 | G/A | — | uncertain significance |
| rs200981073 | 16:683,677 | C/T | — | uncertain significance |
| rs761975795 | 16:683,705 | G/A | — | uncertain significance |
| rs747716027 | 16:683,728 | C/T | — | uncertain significance |
| rs761037038 | 16:683,767 | G/A | — | uncertain significance |
| rs772300719 | 16:683,814 | G/T | — | uncertain significance |
| rs973723994 | 16:683,826 | C/G | — | uncertain significance |
| rs201006114 | 16:683,932 | C/T | — | uncertain significance |
| rs143797074 | 16:683,933 | G/A | — | uncertain significance |
| rs761476941 | 16:683,971 | C/G | — | uncertain significance |
| rs542877970 | 16:683,974 | G/A | — | uncertain significance |
| rs374395816 | 16:683,989 | C/T | — | uncertain significance |
| rs1567199944 | 16:684,014 | T/C | — | uncertain significance |
| rs772941811 | 16:684,034 | C/G | — | uncertain significance |
Gene information from NCBI Gene. Variant classifications from ClinVar.