WNT10A

Wnt family member 10A

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region. [provided by RefSeq, Jul 2008]

Known Variants422 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs886055633	2:219,745,285	C/G	—	uncertain significance
rs556182426	2:219,745,318	T/G	—	likely benign
rs886055634	2:219,745,348	C/A	—	uncertain significance
rs886055635	2:219,745,360	G/A	—	uncertain significance
rs762914440	2:219,745,377	A/G	—	uncertain significance
rs138370318	2:219,745,406	C/T	—	likely benign
rs886055636	2:219,745,433	C/T	—	uncertain significance
rs774035749	2:219,745,448	G/C	—	uncertain significance
rs571829301	2:219,745,469	G/C	—	uncertain significance
rs886055638	2:219,745,516	G/C	—	uncertain significance
rs886055640	2:219,745,565	G/A	—	uncertain significance
rs886055641	2:219,745,569	G/T	—	uncertain significance
rs928677784	2:219,745,595	C/A	—	uncertain significance
rs1042922024	2:219,745,648	G/C	—	uncertain significance
rs1221516695	2:219,745,718	A/T	—	pathogenic
rs111314129	2:219,745,720	G/A	—	pathogenic
rs533605522	2:219,745,721	G/A	—	likely benign
rs1324234734	2:219,745,724	A/T	—	uncertain significance
rs964401766	2:219,745,738	C/T	—	likely benign
rs1197751092	2:219,745,743	G/A	—	pathogenic
rs121908123	2:219,745,744	G/A	stop gained	pathogenic
rs2470301301	2:219,745,750	G/A	—	likely benign
rs1481057549	2:219,745,753	C/T	—	likely benign
rs756946393	2:219,745,754	C/T	—	pathogenic
rs767104236	2:219,745,755	G/C	—	uncertain significance
rs1944506244	2:219,745,756	A/T	—	likely benign
rs1168115806	2:219,745,759	C/A	—	likely benign
rs1364600200	2:219,745,762	G/A	—	likely benign
rs755581771	2:219,745,771	G/A	—	likely benign
rs779424847	2:219,745,776	C/A	—	uncertain significance
rs749864407	2:219,745,779	C/G	—	conflicting classifications of pathogenicity
rs1315655283	2:219,745,780	G/T	—	likely benign
rs1220645831	2:219,745,785	G/A	—	pathogenic
rs2470301392	2:219,745,786	G/A	—	pathogenic
rs772447299	2:219,745,789	G/A	—	likely benign
rs2470301407	2:219,745,792	C/G	—	likely benign
rs1944507077	2:219,745,793	C/T	—	likely benign
rs1553622184	2:219,745,795	G/C	—	likely benign
rs1036358920	2:219,745,798	C/T	—	likely benign
rs115839019	2:219,745,802	C/T	—	benign
rs368241966	2:219,745,804	A/G	—	likely benign
rs1170576151	2:219,745,805	C/T	—	likely benign
rs2470301468	2:219,745,807	G/C	—	likely benign
rs1422380518	2:219,745,811	C/T	—	likely benign
rs1165152782	2:219,745,822	C/G	—	likely benign
rs2470301507	2:219,745,828	C/T	—	likely benign
rs762998852	2:219,745,829	A/T	—	uncertain significance
rs968817879	2:219,745,831	G/A	—	likely pathogenic
rs1322675392	2:219,745,837	C/A	—	likely benign
rs2106010803	2:219,745,838	C/A	—	likely benign
rs2470301535	2:219,745,840	C/T	—	likely benign
rs1264449117	2:219,745,847	T/C	—	likely benign
rs2470301559	2:219,745,849	C/T	—	likely benign
rs10177996	2:219,746,561	T/C	intron variant	—
rs10180544	2:219,746,827	T/C	—	benign
rs2470303108	2:219,746,873	A/T	—	likely benign
rs200446715	2:219,746,875	G/A	—	likely benign
rs149865858	2:219,746,894	A/G	—	likely benign
rs2470303155	2:219,746,900	T/C	—	uncertain significance
rs747317988	2:219,746,901	T/A	—	likely benign
rs2470303163	2:219,746,902	C/T	—	likely benign
rs1479630822	2:219,746,904	G/T	—	likely benign
rs2106011476	2:219,746,907	C/T	—	likely benign
rs199980023	2:219,746,918	C/T	—	conflicting classifications of pathogenicity
rs761730775	2:219,746,919	C/A	—	likely benign
rs372538189	2:219,746,921	C/T	—	uncertain significance
rs143421847	2:219,746,928	C/T	—	likely benign
rs2470303267	2:219,746,931	G/A	—	likely benign
rs992196031	2:219,746,935	A/G	—	uncertain significance
rs758914779	2:219,746,937	T/C	—	likely benign
rs2470303288	2:219,746,943	C/T	—	likely benign
rs765843965	2:219,746,946	A/T	—	likely benign
rs2106011547	2:219,746,953	C/T	—	likely benign
rs2106011549	2:219,746,955	A/G	—	likely benign
rs1163565666	2:219,746,959	T/C	—	likely benign
rs1391749559	2:219,746,961	G/C	—	uncertain significance
rs753324320	2:219,746,968	C/T	—	likely benign
rs772059787	2:219,746,969	T/C	—	uncertain significance
rs904675306	2:219,746,970	G/A	—	likely benign
rs200487809	2:219,746,974	C/T	—	uncertain significance
rs751841151	2:219,746,975	G/A	—	uncertain significance
rs146460077	2:219,746,977	C/T	—	conflicting classifications of pathogenicity
rs368943130	2:219,746,981	A/T	—	uncertain significance
rs373607885	2:219,746,985	G/T	—	uncertain significance
rs1381185098	2:219,746,988	G/A	—	likely benign
rs761027045	2:219,746,999	G/A	—	uncertain significance
rs199802454	2:219,747,003	C/T	—	likely benign
rs1064796619	2:219,747,011	T/C	—	uncertain significance
rs2470303429	2:219,747,012	G/A	—	likely benign
rs1443984375	2:219,747,031	G/A	—	uncertain significance
rs1163224121	2:219,747,036	C/A	—	likely benign
rs1011612159	2:219,747,042	C/T	—	likely benign
rs572942384	2:219,747,043	G/A	—	likely pathogenic
rs1553622317	2:219,747,044	C/T	—	uncertain significance
rs1944527945	2:219,747,045	C/T	—	likely benign
rs2106011654	2:219,747,048	C/T	—	likely benign
rs752237331	2:219,747,051	C/T	—	likely benign
rs318240759	2:219,747,052	G/A	—	pathogenic
rs1285105830	2:219,747,057	C/T	—	likely benign
rs1244745229	2:219,747,063	C/T	—	likely benign

Showing 100 of 422 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.