WRAP53

WD repeat containing antisense to TP53

Summary

This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

Known Variants386 total

rsidPosition (GRCh37)AllelesClassClinVar
rs142131417:7,591,540T/C—likely benign
rs1788318417:7,591,554G/A—benign
rs1788291017:7,591,555T/A—benign
rs105751602717:7,591,653T/G—uncertain significance
rs56433066217:7,591,712G/A—uncertain significance
rs74826594617:7,591,819C/T—uncertain significance
rs7919971817:7,591,829C/T—uncertain significance
rs207405159117:7,591,858C/G—uncertain significance
rs88605351717:7,591,881T/C—uncertain significance
rs207405453217:7,591,961T/C—uncertain significance
rs75268794517:7,591,980A/C—uncertain significance
rs37628634917:7,591,981G/A—likely benign
rs37662191717:7,591,984T/A—likely benign
rs207405522717:7,591,986A/G—uncertain significance
rs54967959117:7,591,990G/A—likely benign
rs254374742417:7,591,995C/T—uncertain significance
rs14069436117:7,591,998C/T—uncertain significance
rs104347101917:7,591,999G/C—likely benign
rs15028262917:7,592,012T/G—uncertain significance
rs126766469417:7,592,020G/C—uncertain significance
rs207405626317:7,592,024C/T—uncertain significance
rs121057133417:7,592,030C/T—uncertain significance
rs76836485617:7,592,043C/T—uncertain significance
rs77607780817:7,592,047C/T—likely benign
rs116203540817:7,592,072G/A—uncertain significance
rs254374798117:7,592,076A/C—uncertain significance
rs76302389717:7,592,077C/T—likely benign
rs103412135017:7,592,088T/C—uncertain significance
rs141725139717:7,592,095G/A—likely benign
rs14217744417:7,592,104A/G—likely benign
rs207405804317:7,592,106G/A—uncertain significance
rs215108477417:7,592,108G/C—uncertain significance
rs36822044717:7,592,110G/A—likely benign
rs37612506417:7,592,120C/T—uncertain significance
rs76271779917:7,592,125G/T—uncertain significance
rs254374837317:7,592,127C/A—uncertain significance
rs76141317917:7,592,164G/A—likely benign
rs77319922517:7,592,169G/C—uncertain significance
rs97609976017:7,592,174G/T—uncertain significance
rs77409577317:7,592,179C/T—likely benign
rs134548647217:7,592,181C/G—uncertain significance
rs76403792717:7,592,183G/A—uncertain significance
rs36938661517:7,592,187C/A—uncertain significance
rs75079454317:7,592,198C/A—uncertain significance
rs207406127217:7,592,201C/A—uncertain significance
rs78063591017:7,592,212G/A—likely benign
rs254374898517:7,592,214T/C—uncertain significance
rs14185083017:7,592,222C/T—uncertain significance
rs177960078917:7,592,223C/T—uncertain significance
rs37215281617:7,592,231T/A—uncertain significance
rs76963743717:7,592,240C/G—uncertain significance
rs55439255617:7,592,246G/A—uncertain significance
rs254374925417:7,592,258C/T—uncertain significance
rs77437455917:7,592,263T/C—likely benign
rs215108507217:7,592,269T/G—uncertain significance
rs75942876517:7,592,271C/T—uncertain significance
rs76746299717:7,592,275C/G—uncertain significance
rs76546260017:7,592,290A/C—uncertain significance
rs15018039417:7,592,296C/T—conflicting classifications of pathogenicity
rs94216039417:7,592,304T/C—uncertain significance
rs170190971717:7,592,312G/A—uncertain significance
rs78171991917:7,592,318G/A—uncertain significance
rs104399327217:7,592,319C/A—uncertain significance
rs215108518117:7,592,320G/A—likely benign
rs75562568217:7,592,324G/A—uncertain significance
rs141776762517:7,592,325G/T—uncertain significance
rs77758842017:7,592,327C/G—uncertain significance
rs121475583017:7,592,339T/C—uncertain significance
rs254374980217:7,592,354G/A—uncertain significance
rs20134074117:7,592,361C/A—uncertain significance
rs215108528517:7,592,366G/A—uncertain significance
rs215108529417:7,592,371A/G—likely benign
rs92972437317:7,592,377T/C—likely benign
rs76661061017:7,592,381G/A—uncertain significance
rs254374999517:7,592,385A/G—uncertain significance
rs1788074017:7,592,412C/T—likely benign
rs1788580317:7,592,482T/C—benign
rs254375138117:7,592,526C/G—likely benign
rs77106328417:7,592,527C/G—conflicting classifications of pathogenicity
rs117506174417:7,592,528C/T—likely benign
rs14722640617:7,592,543G/A—uncertain significance
rs254375160717:7,592,548G/A—conflicting classifications of pathogenicity
rs76468131117:7,592,552T/G—uncertain significance
rs75346131117:7,592,556G/A—uncertain significance
rs57115318517:7,592,567C/G—uncertain significance
rs74679486117:7,592,579C/T—uncertain significance
rs56553000617:7,592,581C/T—likely benign
rs125712609317:7,592,588T/C—uncertain significance
rs78104113617:7,592,589C/T—uncertain significance
rs254375207717:7,592,604G/C—uncertain significance
rs14781752617:7,592,605C/T—conflicting classifications of pathogenicity
rs144351611517:7,592,607C/T—uncertain significance
rs159740466817:7,592,610A/G—uncertain significance
rs77446625417:7,592,612C/T—uncertain significance
rs126946600017:7,592,626G/A—likely benign
rs130471273917:7,592,646G/T—uncertain significance
rs77605185017:7,592,648T/A—likely benign
rs207407506917:7,592,652A/C—likely benign
rs76111307717:7,592,654C/T—likely benign
rs76126396317:7,592,657G/A—likely benign

Showing 100 of 386 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.