XCR1
X-C motif chemokine receptor 1
Summary
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains. The encoded protein transduces a signal by increasing the intracellular calcium ion level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Some studies have implicated a cluster of genes at 3p21.31, including this gene, as associated with COVID-19 risk. The encoded protein may also play a role in cell proliferation and migration in several types of cancer. [provided by RefSeq, Jan 2023]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs529280793 | 3:46,062,490 | G/A | — | uncertain significance |
| rs866621298 | 3:46,062,515 | G/A | — | uncertain significance |
| rs767388130 | 3:46,062,532 | C/T | — | likely benign |
| rs780356065 | 3:46,062,568 | C/T | — | uncertain significance |
| rs551972565 | 3:46,062,629 | T/A | — | uncertain significance |
| rs1236112983 | 3:46,062,632 | G/A | — | uncertain significance |
| rs2529133217 | 3:46,062,653 | G/C | — | uncertain significance |
| rs758007235 | 3:46,062,784 | C/T | — | uncertain significance |
| rs184118987 | 3:46,062,824 | C/A | — | uncertain significance |
| rs1708144736 | 3:46,062,934 | T/G | — | uncertain significance |
| rs369148627 | 3:46,062,939 | G/C | — | uncertain significance |
| rs2529133826 | 3:46,062,974 | C/T | — | uncertain significance |
| rs200624701 | 3:46,062,986 | C/T | — | uncertain significance |
| rs750935046 | 3:46,063,010 | G/A | — | uncertain significance |
| rs145379918 | 3:46,063,091 | T/A | — | uncertain significance |
| rs757224758 | 3:46,063,119 | C/A | — | uncertain significance |
| rs769840470 | 3:46,063,165 | T/C | — | uncertain significance |
| rs377699037 | 3:46,063,199 | C/G | — | uncertain significance |
| rs2529134459 | 3:46,063,219 | C/T | — | uncertain significance |
| rs2529134850 | 3:46,063,334 | C/G | — | uncertain significance |
| rs2529134906 | 3:46,063,372 | T/A | — | uncertain significance |
| rs750354912 | 3:46,063,378 | G/A | — | likely benign |
| rs1708163007 | 3:46,063,396 | T/C | — | uncertain significance |
| rs778906589 | 3:46,063,406 | A/C | — | uncertain significance |
| rs2529135052 | 3:46,063,411 | G/T | — | uncertain significance |
| rs1708164036 | 3:46,063,417 | T/C | — | uncertain significance |
| rs190685138 | 3:46,063,688 | G/A | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.