XIRP2

xin actin binding repeat containing 2

Summary

Enables actin filament binding activity. Predicted to be involved in actin filament organization and regulation of actin filament organization. Predicted to act upstream of or within cardiac muscle tissue morphogenesis; cell-cell junction organization; and ventricular septum development. Located in focal adhesion and stress fiber. Implicated in depressive disorder. [provided by Alliance of Genome Resources, Jul 2025]

Known Variants363 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs117360413	2:167,759,994	T/C	—	likely benign
rs80326955	2:167,760,002	A/G	—	benign
rs373936387	2:167,760,013	C/T	—	likely benign
rs73969928	2:167,760,031	G/A	—	benign
rs747180517	2:167,760,063	G/T	—	uncertain significance
rs555589314	2:167,760,208	T/C	—	likely benign
rs201964938	2:167,760,239	A/G	—	uncertain significance
rs200881042	2:167,760,249	A/C	—	likely benign
rs1175742929	2:167,760,266	C/T	—	uncertain significance
rs199731929	2:167,760,274	A/T	—	uncertain significance
rs188658609	2:167,760,299	A/T	—	uncertain significance
rs1390914076	2:167,760,310	G/T	—	uncertain significance
rs376019989	2:167,760,370	T/G	—	uncertain significance
rs776835140	2:167,760,381	C/T	—	uncertain significance
rs563587066	2:167,970,505	G/A	—	—
rs368235986	2:167,992,438	G/A	—	uncertain significance
rs368577607	2:167,992,471	G/A	—	likely benign
rs1691536571	2:167,992,474	G/T	—	uncertain significance
rs114147582	2:167,992,482	G/A	—	benign
rs546765780	2:167,992,529	T/G	—	uncertain significance
rs2468154710	2:168,041,081	C/T	—	uncertain significance
rs77546992	2:168,041,087	C/T	—	benign
rs201741760	2:168,041,098	T/C	—	benign
rs16853169	2:168,041,152	T/C	—	benign
rs776200202	2:168,067,324	C/T	—	likely benign
rs1559022216	2:168,067,351	G/A	—	uncertain significance
rs2468211373	2:168,067,386	G/C	—	uncertain significance
rs778378248	2:168,074,699	C/T	—	likely benign
rs77709584	2:168,074,705	G/T	—	benign
rs77278822	2:168,074,706	C/T	—	benign
rs184246616	2:168,074,745	G/A	—	likely benign
rs778255402	2:168,074,754	T/A	—	uncertain significance
rs745311034	2:168,074,767	C/T	—	uncertain significance
rs186257471	2:168,096,375	A/G	—	likely benign
rs75422885	2:168,096,408	A/T	—	benign
rs372108576	2:168,096,434	G/A	—	uncertain significance
rs547800851	2:168,096,454	T/G	—	uncertain significance
rs1337129463	2:168,097,179	T/C	—	likely benign
rs201745627	2:168,097,201	G/C	—	likely benign
rs201887325	2:168,097,214	C/A	—	uncertain significance
rs188701859	2:168,097,215	A/C	—	benign
rs369972874	2:168,097,230	A/G	—	likely benign
rs2468276080	2:168,098,292	G/A	—	uncertain significance
rs111563369	2:168,098,296	C/T	—	likely benign
rs1403860266	2:168,098,319	A/C	—	uncertain significance
rs780019537	2:168,098,327	G/A	—	likely benign
rs144071626	2:168,098,394	A/T	—	conflicting classifications of pathogenicity
rs775938810	2:168,098,395	T/C	—	likely benign
rs935432440	2:168,099,105	C/T	—	likely benign
rs2468279415	2:168,099,284	A/C	—	uncertain significance
rs578201875	2:168,099,295	G/A	—	uncertain significance
rs143400009	2:168,099,316	T/C	—	benign
rs767996433	2:168,099,347	T/C	—	likely benign
rs373076577	2:168,099,378	A/C	—	likely benign
rs768621949	2:168,099,385	T/G	—	uncertain significance
rs375603641	2:168,099,400	C/T	—	uncertain significance
rs151314564	2:168,099,500	G/A	—	conflicting classifications of pathogenicity
rs1350637221	2:168,099,527	C/A	—	uncertain significance
rs185796429	2:168,099,557	G/C	—	conflicting classifications of pathogenicity
rs762287780	2:168,099,566	A/G	—	uncertain significance
rs761047736	2:168,099,632	T/C	—	uncertain significance
rs768914467	2:168,099,636	A/T	—	uncertain significance
rs372162249	2:168,099,671	A/G	—	uncertain significance
rs904813037	2:168,099,676	G/C	—	uncertain significance
rs75011196	2:168,099,724	A/G	—	benign
rs749248970	2:168,099,737	G/A	—	uncertain significance
rs10497323	2:168,099,738	T/C	—	benign
rs16853305	2:168,099,775	C/G	—	benign
rs1262569347	2:168,099,777	C/G	—	likely benign
rs376918960	2:168,099,781	G/A	—	uncertain significance
rs191548363	2:168,099,787	C/G	—	uncertain significance
rs16853306	2:168,099,796	T/C	—	benign
rs2468281465	2:168,099,809	C/A	—	uncertain significance
rs2468281537	2:168,099,833	C/A	—	uncertain significance
rs1341068748	2:168,099,900	G/T	—	uncertain significance
rs749630332	2:168,099,909	G/A	—	likely benign
rs182527642	2:168,099,951	C/T	—	benign
rs750387887	2:168,099,970	A/C	—	uncertain significance
rs1573990722	2:168,099,971	A/G	—	uncertain significance
rs777940740	2:168,099,994	A/G	—	uncertain significance
rs201031516	2:168,100,020	G/T	—	uncertain significance
rs768245433	2:168,100,057	A/G	—	likely benign
rs76149079	2:168,100,110	C/T	—	benign
rs1158996360	2:168,100,125	A/G	—	likely benign
rs548985321	2:168,100,213	C/T	—	benign
rs191792139	2:168,100,236	G/A	—	likely benign
rs1053350061	2:168,100,247	T/C	—	uncertain significance
rs201184820	2:168,100,280	G/A	—	uncertain significance
rs2468283497	2:168,100,307	A/G	—	uncertain significance
rs368288888	2:168,100,378	G/T	—	uncertain significance
rs779761167	2:168,100,391	A/T	—	uncertain significance
rs16853307	2:168,100,443	C/A	—	benign
rs183271329	2:168,100,459	C/T	—	benign
rs202096194	2:168,100,489	C/T	—	benign
rs369486374	2:168,100,493	G/A	—	likely benign
rs201385307	2:168,100,553	T/C	—	uncertain significance
rs2468284656	2:168,100,580	T/C	—	uncertain significance
rs1039322185	2:168,100,617	A/T	—	uncertain significance
rs202171099	2:168,100,660	C/A	—	uncertain significance
rs370823923	2:168,100,675	A/G	—	likely benign

Showing 100 of 363 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.