XPO6

exportin 6

Summary

The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Known Variants30 total

rsidPosition (GRCh37)AllelesClassClinVar
rs77552262216:28,113,239C/Tuncertain significance
rs76557234116:28,115,873G/Cuncertain significance
rs37469095416:28,117,402C/Tuncertain significance
rs139452284516:28,117,446T/Cuncertain significance
rs3517810716:28,117,487C/Tbenign
rs146983677216:28,117,776C/Tuncertain significance
rs75210205016:28,118,881A/Cuncertain significance
rs1155774916:28,118,969C/Tuncertain significance
rs74586294716:28,123,198C/Auncertain significance
rs20538416:28,123,226G/Cmissense variant
rs143369650316:28,123,308C/Tuncertain significance
rs36976656916:28,128,703G/Auncertain significance
rs143982745516:28,128,712C/Tuncertain significance
rs20150799016:28,133,103T/Gintron variant
rs20165776416:28,137,151G/Auncertain significance
rs254818975416:28,143,670C/Guncertain significance
rs75163281116:28,145,235C/Tuncertain significance
rs254819189216:28,146,571A/Cuncertain significance
rs74992144316:28,146,641C/Tuncertain significance
rs105610208916:28,157,433T/Auncertain significance
rs118824681716:28,164,015A/Guncertain significance
rs20196475916:28,164,102T/Cuncertain significance
rs37122810016:28,167,564C/Guncertain significance
rs75899549916:28,167,789T/Auncertain significance
rs91841837216:28,177,832T/Auncertain significance
rs78163220316:28,177,846G/Auncertain significance
rs53747838516:28,177,886C/Tuncertain significance
rs37717896116:28,177,906C/Tuncertain significance
rs140396269416:28,181,154C/Tuncertain significance
rs254821811616:28,188,650T/Cuncertain significance

Gene information from NCBI Gene. Variant classifications from ClinVar.