XRN1
5'-3' exoribonuclease 1
Summary
This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Known Variants81 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2065074682 | 3:142,030,370 | A/C | — | uncertain significance |
| rs2065077501 | 3:142,030,474 | T/G | — | uncertain significance |
| rs538110316 | 3:142,030,489 | G/A | — | uncertain significance |
| rs531237147 | 3:142,030,490 | G/A | — | uncertain significance |
| rs777642609 | 3:142,030,535 | G/A | — | uncertain significance |
| rs750880193 | 3:142,030,637 | C/T | — | uncertain significance |
| rs762045860 | 3:142,031,487 | C/T | — | uncertain significance |
| rs556510044 | 3:142,031,499 | T/C | — | uncertain significance |
| rs372791332 | 3:142,031,546 | G/A | — | uncertain significance |
| rs771535258 | 3:142,031,564 | G/A | — | uncertain significance |
| rs2473135181 | 3:142,031,574 | G/T | — | uncertain significance |
| rs200962555 | 3:142,031,589 | G/C | — | uncertain significance |
| rs2473137873 | 3:142,031,985 | C/G | — | uncertain significance |
| rs754540330 | 3:142,037,445 | G/A | — | uncertain significance |
| rs2473162272 | 3:142,037,470 | G/A | — | uncertain significance |
| rs753858282 | 3:142,037,736 | C/T | — | uncertain significance |
| rs2107909544 | 3:142,048,403 | A/G | — | uncertain significance |
| rs115294670 | 3:142,048,450 | A/G | — | benign |
| rs770978242 | 3:142,051,366 | C/T | — | uncertain significance |
| rs760535063 | 3:142,051,814 | C/T | — | uncertain significance |
| rs763372386 | 3:142,051,853 | C/T | — | uncertain significance |
| rs200402336 | 3:142,051,882 | T/G | — | uncertain significance |
| rs2473262222 | 3:142,054,302 | C/A | — | uncertain significance |
| rs746980400 | 3:142,054,310 | G/C | — | uncertain significance |
| rs1452369838 | 3:142,066,118 | T/C | — | uncertain significance |
| rs145776184 | 3:142,066,144 | T/C | — | uncertain significance |
| rs1333418303 | 3:142,074,335 | G/A | — | likely benign |
| rs758699895 | 3:142,075,787 | G/T | — | uncertain significance |
| rs775051276 | 3:142,075,833 | T/C | — | uncertain significance |
| rs145647005 | 3:142,075,896 | C/T | — | uncertain significance |
| rs757605438 | 3:142,075,960 | A/C | — | uncertain significance |
| rs113785658 | 3:142,079,543 | A/C | intron variant | — |
| rs766861239 | 3:142,083,924 | A/G | — | uncertain significance |
| rs199951373 | 3:142,088,497 | A/T | — | — |
| rs775437670 | 3:142,090,148 | T/C | — | uncertain significance |
| rs115454798 | 3:142,092,190 | A/G | — | — |
| rs977856255 | 3:142,094,677 | A/G | — | uncertain significance |
| rs2472625745 | 3:142,095,412 | C/T | — | uncertain significance |
| rs2472640562 | 3:142,098,971 | T/G | — | uncertain significance |
| rs1464645267 | 3:142,099,000 | A/G | — | uncertain significance |
| rs185717662 | 3:142,099,031 | A/G | — | likely benign |
| rs73238169 | 3:142,099,367 | G/A | intron variant | — |
| rs7623513 | 3:142,100,428 | A/C | intron variant | — |
| rs7627694 | 3:142,100,478 | T/G | — | — |
| rs2472655606 | 3:142,102,189 | T/A | — | uncertain significance |
| rs368411156 | 3:142,102,240 | C/T | — | uncertain significance |
| rs7631518 | 3:142,111,435 | C/A | — | — |
| rs73238176 | 3:142,114,256 | G/A | intron variant | — |
| rs778270766 | 3:142,116,202 | A/T | — | uncertain significance |
| rs1577360797 | 3:142,116,238 | T/C | — | uncertain significance |
| rs765555671 | 3:142,116,241 | A/G | — | uncertain significance |
| rs7633870 | 3:142,118,914 | A/T | — | — |
| rs2472741007 | 3:142,119,307 | G/C | — | likely benign |
| rs913446133 | 3:142,119,354 | T/G | — | uncertain significance |
| rs754322531 | 3:142,119,386 | C/T | — | likely benign |
| rs369924329 | 3:142,122,553 | A/G | — | uncertain significance |
| rs141165757 | 3:142,122,812 | C/G | — | uncertain significance |
| rs368437053 | 3:142,123,773 | G/A | — | uncertain significance |
| rs144282619 | 3:142,133,008 | G/A | — | uncertain significance |
| rs373000608 | 3:142,133,094 | T/C | — | uncertain significance |
| rs1319835072 | 3:142,136,015 | T/C | — | uncertain significance |
| rs777191632 | 3:142,137,373 | G/A | — | uncertain significance |
| rs756104773 | 3:142,137,419 | G/C | — | uncertain significance |
| rs11714244 | 3:142,138,294 | C/T | downstream gene variant | — |
| rs374124796 | 3:142,139,872 | T/C | — | uncertain significance |
| rs143458115 | 3:142,139,919 | T/C | — | uncertain significance |
| rs747742395 | 3:142,139,988 | C/T | — | uncertain significance |
| rs749222593 | 3:142,140,358 | T/C | — | uncertain significance |
| rs772148843 | 3:142,140,380 | T/C | — | uncertain significance |
| rs192805321 | 3:142,141,453 | G/A | — | uncertain significance |
| rs2069096329 | 3:142,141,693 | T/G | — | uncertain significance |
| rs376352455 | 3:142,141,760 | A/G | — | uncertain significance |
| rs772740589 | 3:142,142,403 | G/A | — | uncertain significance |
| rs187669081 | 3:142,142,414 | T/C | — | uncertain significance |
| rs2472867497 | 3:142,144,067 | G/T | — | uncertain significance |
| rs2108130265 | 3:142,145,646 | T/A | — | uncertain significance |
| rs2472919036 | 3:142,151,583 | T/C | — | likely benign |
| rs534203521 | 3:142,151,638 | T/C | — | uncertain significance |
| rs2472919596 | 3:142,151,641 | T/A | — | uncertain significance |
| rs1331448431 | 3:142,151,660 | C/T | — | uncertain significance |
| rs148138774 | 3:142,154,187 | C/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.